Rimjhim Agarwal
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View article: Identification of immunogenic and cross-reactive chikungunya virus epitopes for CD4+ T cells in chronic chikungunya disease
Identification of immunogenic and cross-reactive chikungunya virus epitopes for CD4+ T cells in chronic chikungunya disease Open
View article: Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans
Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans Open
Chikungunya virus (CHIKV) is a mosquito-borne virus that can cause chronic chikungunya virus disease (CHIKVD), which is characterized by persistent incapacitating arthralgia. Despite recurring CHIKV outbreaks and recent approval of a vacci…
View article: Identification of immunogenic and cross-reactive chikungunya virus-specific CD4<sup>+</sup>T cell epitopes in chronic chikungunya viral arthritic disease in humans
Identification of immunogenic and cross-reactive chikungunya virus-specific CD4<sup>+</sup>T cell epitopes in chronic chikungunya viral arthritic disease in humans Open
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes acute febrile illness that can progress into chronic chikungunya virus disease (CHIKVD) marked by persistent debilitating arthralgia. At present, the exact cause of chronic CHI…
View article: Chikungunya-virus-specific CD4<sup>+</sup>T cells are associated with chronic chikungunya viral arthritic disease in humans
Chikungunya-virus-specific CD4<sup>+</sup>T cells are associated with chronic chikungunya viral arthritic disease in humans Open
SUMMARY Chikungunya virus (CHIKV) is a mosquito-borne re-emerging viral infection that can cause chronic chikungunya viral arthritic disease (CHIKVD), which is characterized by incapacitating arthralgia and inflammation that can last for m…
View article: Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome Open
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CL pro ) encoded…
View article: Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages
Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages Open
RNA viruses have short generation times and high mutation rates, allowing them to undergo rapid molecular evolution during epidemics. However, the extent of RNA virus phenotypic evolution within epidemics and the resulting effects on fitne…
View article: Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome Open
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CL pro ) encoded…
View article: Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages
Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages Open
RNA viruses have short generation times and high mutation rates, allowing them to undergo rapid molecular evolution during epidemics. However, the extent of RNA virus phenotypic evolution within epidemics and the resulting effects on fitne…
View article: Author response: Diverse viral proteases activate the NLRP1 inflammasome
Author response: Diverse viral proteases activate the NLRP1 inflammasome Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The NLRP1 inflammasome is a m…
View article: Diverse viral proteases activate the NLRP1 inflammasome
Diverse viral proteases activate the NLRP1 inflammasome Open
The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-termin…