Rin Yanai
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View article: Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability Open
Neurodegenerative diseases are characterized by progressive neuronal loss, yet subtle degeneration remains difficult to detect, hindering advancements in early diagnosis and intervention strategies. Here, we present a 3D, whole-brain, sing…
View article: A novel tauopathy model mimicking molecular and spatial aspects of human tau pathology
A novel tauopathy model mimicking molecular and spatial aspects of human tau pathology Open
Creating a mouse model that recapitulates human tau pathology is essential for developing strategies to intervene in tau-induced neurodegeneration. However, mimicking the pathological features seen in human pathology often involves a trade…
View article: Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy
Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy Open
Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy. There is no disease-modifying drug available for …
View article: Loss of <i>Axdnd1</i> causes sterility due to impaired spermatid differentiation in mice
Loss of <i>Axdnd1</i> causes sterility due to impaired spermatid differentiation in mice Open
Purpose Spermiogenesis, the process of deformation of sperm head morphology and flagella formation, is a phenomenon unique to sperm. Axonemal dynein light chain proteins are localized to sperm flagella and are known to be involved in sperm…
View article: Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice
Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice Open
The structure of microtubules is essential for the fertilizing ability of spermatozoa. Acetylation of α-tubulin plays an important role in flagellar elongation and spermatozoa motility. Previous reports have suggested that alpha-tubulin N-…
View article: Improvement in blastocyst quality by neurotensin signaling via its receptors in bovine spermatozoa during <i>in vitro</i> fertilization
Improvement in blastocyst quality by neurotensin signaling via its receptors in bovine spermatozoa during <i>in vitro</i> fertilization Open
Previously, we reported that neurotensin (NT), which is expressed in the uterus and oviduct, enhanced bovine sperm capacitation and acrosome reactions. As NT mRNA expression in bovine oviducts increases dramatically in the follicular phase…