Rina Zelmann
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View article: The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond
The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond Open
As the pace of research in implantable neurotechnology increases, it is important to take a step back and see if the promise lives up to our intentions. While direct electrical stimulation applied intracranially has been used for the treat…
View article: Theta-burst direct electrical stimulation remodels human brain networks
Theta-burst direct electrical stimulation remodels human brain networks Open
Theta-burst stimulation (TBS), a patterned brain stimulation technique that mimics rhythmic bursts of 3-8 Hz endogenous brain rhythms, has emerged as a promising therapeutic approach for treating a wide range of brain disorders, though the…
Theta-burst direct electrical stimulation remodels human brain networks Open
Patterned brain stimulation is a powerful therapeutic approach for treating a wide range of brain disorders. In particular, theta-burst stimulation (TBS), characterized by rhythmic bursts of 3-8 Hz mirroring endogenous brain rhythms, is de…
SEEGAtlas: A framework for the identification and classification of depth electrodes using clinical images Open
Objective. Accurate localization, classification, and visualization of intracranial electrodes are fundamental for analyzing intracranial electrographic recordings. While manual contact localization is the most common approach, it is time-…
Differential Cortical Network Engagement During States of Un/Consciousness in Humans Open
What happens in the human brain when we are unconscious? Despite substantial work, we are still unsure which brain regions are involved and how they are impacted when consciousness is disrupted. Using intracranial recordings and direct ele…
Stimulation evoked epileptic pathological activity is altered by brain state - insight from invasive and non-invasive recordings Open
It is well known that spontaneous epileptic activity increases during sleep. On the other hand, the brain's physiological response to electrical stimulation during sleep is less complex with reduced effective connectivity (as presented by …
Differential Cortical Network Engagement During States of Un/Consciousness in Humans Open
The neural basis of consciousness remains a major unresolved issue in human neuroscience, with theories of consciousness and experimental studies differing concerning which brain regions are necessary for consciousness. Direct experimental…
Differential Cortical Network Engagement During States of Un/Consciousness Open
The neural basis of consciousness remains a major unresolved issue in human neuroscience. To better understand how cortical networks are engaged during different states of consciousness, we utilized multi-region intracranial single-pulse d…
Characterizing ketamine-induced dissociation using human intracranial neurophysiology: brain dynamics, network activity, and interactions with propofol Open
Summary Subanesthetic doses of ketamine produce rapid and sustained anti-depressant effects in patients with treatment-resistant depression. Unfortunately, the usefulness of ketamine as a treatment is limited by its potential for abuse bec…
Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters Open
These results demonstrate that a stronger local response may require stimulation in the grey-white boundary while stimulation in the white matter could be needed for network activation. Thus, stimulation parameters tailored for a specific …
Impact of stimulation location relative to grey and white matter on single pulse electrical stimulation responses in the human brain Open
Background Electrical neuromodulation is an increasingly common therapy for a wide variety of neuropsychiatric diseases. Unfortunately, therapeutic efficacy is inconsistent, possibly a result of our limited understanding of the mechanisms …
Distinguishing false and true positive detections of high frequency oscillations Open
Objective. High frequency oscillations (HFOs) are a promising biomarker of tissue that instigates seizures. However, ambiguous data and random background fluctuations can cause any HFO detector (human or automated) to falsely label non-HFO…
Effect of Closed-Loop Direct Electrical Stimulation during Sleep Spindles in Humans Open
Sleep spindles are transient oscillations in the brain related to sleep consolidation and memory. We investigated if brief, localized electrical pulses could perturb spindles on five human patients with intracerebral electrodes implanted f…
Closed loop enhancement and neural decoding of human cognitive control Open
Cognitive control is the ability to withhold a default, prepotent response in favor of a more adaptive choice. Control deficits are common across mental disorders, including depression, anxiety, and addiction. Thus, a method for improving …
CLoSES: A platform for closed-loop intracranial stimulation in humans Open
Targeted interrogation of brain networks through invasive brain stimulation has become an increasingly important research tool as well as a therapeutic modality. The majority of work with this emerging capability has been focused on open-l…
Bidirectional modulation of human emotional conflict resolution using intracranial stimulation Open
The ability to regulate emotions in the service of meeting ongoing goals and task demands is a key aspect of adaptive human behavior in our volatile social world. Consequently, difficulties in processing and responding to emotional stimuli…
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Removing high-frequency oscillations Open
On an individual patient level, a prediction of outcome was not possible in all patients. This may be due to the analysis techniques used. Alternatively, HFOs may be less specific for epileptic tissue than earlier studies have indicated.
Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy Open
Detection of epileptic spikes in MagnetoEncephaloGraphy (MEG) requires synchronized neuronal activity over a minimum of 4cm2. We previously validated the Maximum Entropy on the Mean (MEM) as a source localization able to recover the spatia…