Rinkesh Kumar Gupta
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View article: LIGHT-Lymphotoxin beta receptor activity regulates collagen synthesis in lung fibroblasts and is crucial for lung fibrosis in a mouse model of severe asthma 4641
LIGHT-Lymphotoxin beta receptor activity regulates collagen synthesis in lung fibroblasts and is crucial for lung fibrosis in a mouse model of severe asthma 4641 Open
Description Severe asthma is characterized by airway remodeling and peribronchial fibrosis. Fibroblasts produce collagen and other matrix proteins, but factors that are essential to drive fibroblast activity in asthma are not well understo…
View article: CD30L blockade attenuates atopic dermatitis skin inflammation 2425
CD30L blockade attenuates atopic dermatitis skin inflammation 2425 Open
Description Inhibiting IL-13 has proven to be very effective in patients with Th2-biased atopic dermatitis (AD). Additionally, recent successes in clinical trials targeting the T cell costimulatory molecules OX40 and OX40L (TNFSF4) indicat…
View article: Photoacclimation strategies in cyanobacterial photosynthesis under dynamic light environments: implications in growth, fitness, and biotechnological applications
Photoacclimation strategies in cyanobacterial photosynthesis under dynamic light environments: implications in growth, fitness, and biotechnological applications Open
Cyanobacteria, ancient oxygenic photoautotrophs originated in the Precambrian period, exhibit remarkable adaptability to diverse ecological systems. Light, a critical environmental factor, exerts differential pressures on these organisms. …
View article: LIGHT in combination with IL-13 or IL-17 drives inflammatory transcriptional signatures in human pulmonary fibroblasts relevant for human lung disease
LIGHT in combination with IL-13 or IL-17 drives inflammatory transcriptional signatures in human pulmonary fibroblasts relevant for human lung disease Open
Fibroblasts are structural cells primarily involved in tissue remodeling, but recent single-cell RNA sequencing (RNA-seq) transcriptomic data have highlighted their potential to display molecules linked to inflammation. The factors that dr…
View article: Cyanobacterial green chemistry: a blue-green approach for a sustainable environment, energy, and chemical production
Cyanobacterial green chemistry: a blue-green approach for a sustainable environment, energy, and chemical production Open
Increased human activity due to the ever-increasing global population has necessitated the urgent need for a sustainable environment, food, and energy.
View article: Comparison of <scp>CD30L</scp> and <scp>OX40L</scp> Reveals <scp>CD30L</scp> as a Promising Therapeutic Target in Atopic Dermatitis
Comparison of <span>CD30L</span> and <span>OX40L</span> Reveals <span>CD30L</span> as a Promising Therapeutic Target in Atopic Dermatitis Open
Background Blocking IL‐13 is highly efficacious in patients with Th2‐biased atopic dermatitis (AD), and recent clinical data have highlighted that targeting the T cell costimulatory molecules OX40 and OX40L (TNFSF4) holds promise for futur…
View article: LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation
LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation Open
View article: Integrative Keratinocyte Responses to TWEAK with IL-13 and IL-22 Reveal Pathogenic Transcriptomes Associated with Atopic Dermatitis
Integrative Keratinocyte Responses to TWEAK with IL-13 and IL-22 Reveal Pathogenic Transcriptomes Associated with Atopic Dermatitis Open
View article: Responding to light signals: a comprehensive update on photomorphogenesis in cyanobacteria
Responding to light signals: a comprehensive update on photomorphogenesis in cyanobacteria Open
View article: TNF‐like weak inducer of apoptosis inhibition is comparable to IL‐13 blockade in ameliorating atopic dermatitis inflammation
TNF‐like weak inducer of apoptosis inhibition is comparable to IL‐13 blockade in ameliorating atopic dermatitis inflammation Open
Background Targeting IL‐13 is highly efficacious in patients with Th2‐biased atopic dermatitis (AD), but inhibition of other inflammatory molecules might also limit disease. We investigated the importance of the TNF family cytokine TNF‐lik…
View article: The Potential of Therapeutic Targeting of the TWEAK-Fn14 pathway in Atopic Dermatitis
The Potential of Therapeutic Targeting of the TWEAK-Fn14 pathway in Atopic Dermatitis Open
Atopic dermatitis (AD) is a chronic skin inflammatory condition exhibiting a markedly thickened epidermis. Keratinocytes, the major cells of the epidermis, are a key target of inflammation and several cytokines including IL-13 and IL-22 ha…
View article: Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction
Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction Open
View article: A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis
A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis Open
Eosinophilic esophagitis (EoE) is a chronic type 2 allergic disease, with esophageal tissue remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to be a central driver of disease, but other inflammatory fa…
View article: TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy
TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy Open
TWEAK synergizes with TNF and IL-17 in keratinocytes to drive psoriasis-like skin inflammation.
View article: Combination blockade of OX40L and CD30L inhibits allergen-driven memory TH2 cell reactivity and lung inflammation
Combination blockade of OX40L and CD30L inhibits allergen-driven memory TH2 cell reactivity and lung inflammation Open