Rintu Sharma
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View article: P0923 Impact of Inflammatory Bowel Disease on Women’s Health
P0923 Impact of Inflammatory Bowel Disease on Women’s Health Open
Background Inflammatory bowel disease presents chronic challenges that disrupt physical well-being and create significant psychosocial stressors. Despite known gender-specific issues, data on how IBD affects women, particularly in a socio-…
View article: P1098 The Clinical Spectrum of Acute Severe Ulcerative Colitis in the Biologic Era
P1098 The Clinical Spectrum of Acute Severe Ulcerative Colitis in the Biologic Era Open
Background Acute severe ulcerative colitis (ASUC) is a time critical situation requiring urgent intervention. Limited data exist on the evolving clinical spectrum of ASUC in the era of advanced therapies. Methods This prospective cohort st…
View article: Outcomes of Patients with Refractory and Relapsed Primary Mediastinal B Cell Lymphoma: A Canadian Single-Center Analysis
Outcomes of Patients with Refractory and Relapsed Primary Mediastinal B Cell Lymphoma: A Canadian Single-Center Analysis Open
Background: Primary Mediastinal B- Cell Lymphoma (PMBCL) is an aggressive, rare non-Hodgkin Lymphoma. Despite improved outcomes with rituximab-based frontline therapy, approximately 10-15% of patients are either primary refractory or relap…
View article: Real World Outcomes in Adult Histiocytosis: 23-Year Canadian Single Center Analysis
Real World Outcomes in Adult Histiocytosis: 23-Year Canadian Single Center Analysis Open
Background: Adult histiocytic disorders are rare. Existing knowledge has largely been extrapolated from the pediatric counterparts. Langerhans Cell Histiocytosis (LCH), Erdheim Chester Disease (ECD) and Rosai-Dorfman Disease (RDD) are thre…
View article: Autologous stem cell transplantation can potentially reverse dialysis dependence in patients with myeloma: Report of two cases and practical considerations
Autologous stem cell transplantation can potentially reverse dialysis dependence in patients with myeloma: Report of two cases and practical considerations Open
Background Autologous stem cell transplantation (ASCT) is potentially beneficial for patients with myeloma-related renal impairment but is associated with high rates of complications in dialysis-dependent patients and requires specific pre…
View article: High-Risk Myeloma: Definitions and Treatments
High-Risk Myeloma: Definitions and Treatments Open
Multiple myeloma is characterized by clonal proliferation of biologically heterogeneous plasma cells, leading to diverse clinical presentations and outcomes. Although outcomes have improved dramatically over the past decade with the rapid …
View article: Destructive cervical spine disease with concomitant chronic myeloid leukemia: A case report
Destructive cervical spine disease with concomitant chronic myeloid leukemia: A case report Open
A significant majority of patients with chronic myeloid leukemia (CML) present with chronic-phase disease and demonstrate an excellent long-term response to therapy. However, for patients presenting with advanced-phase disease, treatment m…
View article: Deceptive Presentation of Low-Grade Lymphoma with Grade 3 Marrow Fibrosis and Aplasia: Diagnostic and Clinical Considerations
Deceptive Presentation of Low-Grade Lymphoma with Grade 3 Marrow Fibrosis and Aplasia: Diagnostic and Clinical Considerations Open
Bone marrow fibrosis with lymphoproliferative disorders is rare with the exception of hairy cell leukemia and nodular sclerosis Hodgkin's lymphoma. We report the case of a 63-year-old gentleman with indolent B-cell lymphoma presenting with…
View article: Simultaneous presentation of chronic lymphoid leukemia and multiple myeloma
Simultaneous presentation of chronic lymphoid leukemia and multiple myeloma Open
Dear Editor, Multiple myeloma (MM) is a common hematologic malignancy with an annual incidence of 0.53 to 5 per 100,000 populations.[1] It arises from post germinal center B cells and shares many biologic characteristics with other B cell …
View article: Cutis verticis gyrata secondary to T-cell acute lymphoblastic leukemia: Second reported case
Cutis verticis gyrata secondary to T-cell acute lymphoblastic leukemia: Second reported case Open
Leukemia cutis is an extramedullary infiltration of neoplastic cells in the epidermis, dermis, or subcutis, resulting in clinically identifiable skin lesions.[1] It is a rare manifestation of hematologic cancers, with an overall incidence …
View article: Autologous stem cell transplantation for multiple myeloma in the novel agent era: Systematic review of Indian data and implications for resource constrained settings
Autologous stem cell transplantation for multiple myeloma in the novel agent era: Systematic review of Indian data and implications for resource constrained settings Open
Treatment of multiple myeloma has undergone significant advances in the last two decades, leading to meaningful improvement in overall and progression free survival. The incurable nature of disease necessitates serial sequencing of treatme…
View article: Case for More Autologous Transplants in Myeloma in Resource-Constrained Settings
Case for More Autologous Transplants in Myeloma in Resource-Constrained Settings Open
Multiple myeloma is characterized by a near universal risk of relapse. Autologous stem cell transplantation provides a significant progression free survival benefit but is under utilized worldwide. We provide a small snapshot of why ASCT a…
View article: Emerging Role of Hypomethylating Agents Based on Epigenetic Modifications in Relapsed Refractory Multiple Myeloma
Emerging Role of Hypomethylating Agents Based on Epigenetic Modifications in Relapsed Refractory Multiple Myeloma Open
Epigenetics is defined as changes in genetic function without alteration of the underlying genetic code.[1] Dysregulation of normal epigenetic control in plasma cells is being increasingly described with effects on disease pathogenesis, dr…
View article: Epigenetic Modifications in Myeloma: Focused Review of Current Data and Potential Therapeutic Applications
Epigenetic Modifications in Myeloma: Focused Review of Current Data and Potential Therapeutic Applications Open
Multiple myeloma is a common hematologic malignancy with an incidence of 1 per 100,000 population and is characterized by a nearly 100% risk of relapse, necessitating treatment with newer therapeutic agents at each instance of progression.…
View article: Butter in blood: hypertriglyceridemia secondary to pegylated
Butter in blood: hypertriglyceridemia secondary to pegylated Open
Butter in blood: hypertriglyceridemia secondary to pegylated A 44-year-old gentleman was diagnosed with B cell acute lymphoblastic leukemia (ALL) and was being treated with modified BFM90 chemotherapy protocol.He had received daunorubicin,…