Risa Watanabe
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View article: Production of bioactive cytokines using plant expression system for cardiovascular cell differentiation from human pluripotent stem cells
Production of bioactive cytokines using plant expression system for cardiovascular cell differentiation from human pluripotent stem cells Open
Bioactive cytokines such as vascular endothelial growth factor (VEGF) and Activin A are critical for the differentiation of stem cells into vascular endothelial cells and cardiomyocytes. However, production of the cytokines using conventio…
View article: MORE-RNAseq: a pipeline for quantifying retrotransposition-capable LINE1 expression based on RNA-seq data
MORE-RNAseq: a pipeline for quantifying retrotransposition-capable LINE1 expression based on RNA-seq data Open
Retrotransposon long interspersed nuclear element-1 (LINE-1, L1) constitutes a large proportion of the mammalian genome. A fraction of L1s, which have no deleterious mutations in the structure, can amplify their copies via a process called…
View article: Diagnostic and prognostic biomarkers for progressive fibrosing interstitial lung disease
Diagnostic and prognostic biomarkers for progressive fibrosing interstitial lung disease Open
No biomarkers have been identified in bronchoalveolar lavage fluid (BALF) for predicting fibrosis progression or prognosis in progressive fibrosing interstitial lung disease (PF-ILD). We investigated BALF biomarkers for PF-ILD diagnosis an…
View article: A Phase 1 Study of KHK4083: A Single‐Blind, Randomized, Placebo‐Controlled Single‐Ascending‐Dose Study in Healthy Adults and an Open‐Label Multiple‐Dose Study in Patients With Ulcerative Colitis
A Phase 1 Study of KHK4083: A Single‐Blind, Randomized, Placebo‐Controlled Single‐Ascending‐Dose Study in Healthy Adults and an Open‐Label Multiple‐Dose Study in Patients With Ulcerative Colitis Open
OX40 plays an essential role in maintaining late T‐cell proliferation and survival by suppressing apoptosis and by inducing T‐cell memory formation. Here, we report the results of the phase 1 study of KHK4083, a fully human antimonoclonal …
View article: Modular flavor symmetry on a magnetized torus
Modular flavor symmetry on a magnetized torus Open
We study the modular invariance in magnetized torus models. Modular invariant\nflavor model is a recently proposed hypothesis for solving the flavor puzzle,\nwhere the flavor symmetry originates from modular invariance. In this framework\n…
View article: How Cardiovascular Nurses Perceive the Need for Advanced Care Planning for Chronic Heart Failure with Patients and Their Families
How Cardiovascular Nurses Perceive the Need for Advanced Care Planning for Chronic Heart Failure with Patients and Their Families Open
【目的】慢性心不全患者とその家族と多職種チームが行うアドバンス・ケア・プランニング（ACP）に関する看護師の認識を明らかにする．【方法】質問紙を用いて全国の植え込み型除細動器／心臓再同期療法認定施設の看護師427名に，模擬症例とその家族と行うACP13項目の必要性を尋ねた．【結果】有効回答207名中，「機能予後・生命予後を伝える」を患者と「行うべき」と回答した者は51％で，全13項目中最少だった．患者・家族の比較では予後告知などに関する8項目で家族と行うべきとの回答が有意に…
View article: The outcomes of anatomical lung resection for nontuberculous mycobacterial lung disease
The outcomes of anatomical lung resection for nontuberculous mycobacterial lung disease Open
Surgical resection was a feasible treatment for NTM lung disease and was associated with favorable outcomes, although there was 1 case of hospital mortality. VATS procedures were considered adequate for the treatment of NTM lung disease; h…
View article: PM499. Improvement of cognitive function before and after 2-year treatment with long-acting injection (LAI) of antipsychotics evaluated by NIRS using single word-induced hemoglobin variation as an index
PM499. Improvement of cognitive function before and after 2-year treatment with long-acting injection (LAI) of antipsychotics evaluated by NIRS using single word-induced hemoglobin variation as an index Open
Traditionally, delusions have been considered to be the products of misinterpretation and irrationality.However, some theorists have argued that delusions are normal or rational cognitive responses to abnormal experiences.That is, when a r…
View article: A review of twelve cases of resected pleomorphic carcinoma
A review of twelve cases of resected pleomorphic carcinoma Open
背景：肺原発多形癌は1999年のWHO分類ではじめて独立した組織型として提唱された．多彩な病理像を呈し，予後は不良である．肺原発多形癌手術例の臨床像と予後を検討した．対象：2010年11月から2014年10月の間に手術を施行し，肺原発多形癌と病理診断された12例．結果：男性10例，女性2例で平均年齢は62.8歳であった．12例中11例で喫煙歴を認めた．10例が右上葉原発であった．術前のCTで腫瘍径を経時的に測定し得た7例での腫瘍倍加時間の中央値は81日であった．術式は肺全摘…