Rishab Gulati
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View article: Single-cell profiling of CD11c+ B cells in atherosclerosis
Single-cell profiling of CD11c+ B cells in atherosclerosis Open
Circulating CD11c+ B cells, a novel subset of activated B cells, have been linked to autoimmunity and shown to expand with age. Atherosclerosis is an age-associated disease that involves innate and adaptive immune responses to modified sel…
View article: Single-cell profiling reveals inflammatory polarization of human carotid versus femoral plaque leukocytes
Single-cell profiling reveals inflammatory polarization of human carotid versus femoral plaque leukocytes Open
Femoral atherosclerotic plaques are less inflammatory than carotid plaques histologically, but limited cell-level data exist regarding comparative immune landscapes and polarization at these sites. We investigated intraplaque leukocyte phe…
View article: Single cell transcriptomic changes of CD8T cells in male and female patients with coronary artery disease and diabetes
Single cell transcriptomic changes of CD8T cells in male and female patients with coronary artery disease and diabetes Open
Objective The objective of this study was to determine the role of CD8+ T cells in subjects with coronary artery disease (CAD) with and without diabetes (DM). Methods PBMCs of 60 men and women who underwent cardiac catheterization were int…
View article: Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells Open
Background Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relevant data in clinical studies. Here, we developed combined protein (40 antibodies) and transcript single-ce…
View article: Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells
Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells Open
Despite the decades-old knowledge that males and people with diabetes mellitus (DM) are at increased risk for coronary artery disease (CAD), the reasons for this association are only partially understood. Among the immune cells involved, r…
View article: Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells
Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells Open
Background Despite the decades-old knowledge that diabetes mellitus (DM) is a major risk factor for cardiovascular disease (CVD), the reasons for this association are only partially understood. Among the immune cells involved in CVD develo…
View article: Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease
Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease Open
Background: Recent studies have suggested that IgE sensitization to α-gal is associated with coronary artery disease (CAD). However, the B cell subtype(s) responsible for production of IgE to α-gal and mechanisms mediating this production …
View article: Additional file 3 of Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
Additional file 3 of Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells Open
Additional file 3: Data S2. (separate excel file). Data underlying Figure 6, random forest model.
View article: Additional file 2 of Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
Additional file 2 of Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells Open
Additional file 2: Data S1. (separate excel file). Data underlying Figure 5, dotplots of DEGs for disease types.
View article: Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells
Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells Open
Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relevant data in clinical studies. Here, we developed combined protein (40 antibodies) and transcript single cell (sc)RNA …