Rishith Ramamurthy
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View article: TMET-14. PROBING TCA CYCLE ACTIVITY IN H3WT AND H3K27M-ALTERED DIFFUSE MIDLINE GLIOMAS
TMET-14. PROBING TCA CYCLE ACTIVITY IN H3WT AND H3K27M-ALTERED DIFFUSE MIDLINE GLIOMAS Open
DMG has high levels of α-ketoglutarate (α-KG), causing histone hypomethylation and promoting tumor growth. Therefore, targeting α-KG production in DMG tumors may be of therapeutic value. α-KG is synthesized in the tricarboxylic acid cycle …