Rishma Vidyasagar
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View article: Quantitative susceptibility mapping of the fear circuit: Associations with silent symptoms in relapsing-remitting multiple sclerosis
Quantitative susceptibility mapping of the fear circuit: Associations with silent symptoms in relapsing-remitting multiple sclerosis Open
Background: Multiple sclerosis (MS) is a long-term autoimmune inflammatory disorder that affects the central nervous system leading to neurodegeneration, and can involve a variety of symptoms. These symptoms can include fatigue, anxiety, d…
View article: Single‐session reproducibility of MR spectroscopy measures of glutathione in the mesial temporal lobe with MEGA‐PRESS
Single‐session reproducibility of MR spectroscopy measures of glutathione in the mesial temporal lobe with MEGA‐PRESS Open
Background and Purpose Magnetic resonance spectroscopy (MRS) measures neurochemicals in vivo. Glutathione (GSH) is a neuroprotective chemical shown to vary significantly in patients with Alzheimer's disease (AD). This work investigates the…
View article: Structural Connectivity Remote From Lesions Correlates With Somatosensory Outcome Poststroke
Structural Connectivity Remote From Lesions Correlates With Somatosensory Outcome Poststroke Open
Background and Purpose: Changes in connectivity of white matter fibers remote to a stroke lesion, suggestive of structural connectional diaschisis, may impact on clinical impairment and recovery after stroke. However, until recently, we ha…
View article: Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores
Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores Open
Background. One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in res…
View article: A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology
A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology Open
This study has shown it is feasible to quantify acute change in temporal lobe and total oedema volumes in HSV encephalitis and suggests a potential resolution of swelling in response to corticosteroid therapy. These techniques could be use…
View article: Structural and physiological neurovascular changes in idiopathic Parkinson’s disease and its clinical phenotypes
Structural and physiological neurovascular changes in idiopathic Parkinson’s disease and its clinical phenotypes Open
Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson’s disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling…
View article: Quantitative measurement of blood flow in paediatric brain tumours—a comparative study of dynamic susceptibility contrast and multi time-point arterial spin labelled MRI
Quantitative measurement of blood flow in paediatric brain tumours—a comparative study of dynamic susceptibility contrast and multi time-point arterial spin labelled MRI Open
ASL provides information which is comparable with that of DSC in healthy tissues, but appears to reflect a different physiology in tumour tissues.