Rita Afriyie Boateng
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View article: Tissue tropism and functional adaptation of the SARS-CoV-2 spike protein in a fatal case of COVID-19
Tissue tropism and functional adaptation of the SARS-CoV-2 spike protein in a fatal case of COVID-19 Open
Systemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to extrapulmonary tissues has been observed following acute infections. Autopsy studies further indicate tissue-specific virus diversity, including in immune-p…
View article: Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study
Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study Open
The continual rise in sulfadoxine (SDX) resistance affects the therapeutic efficacy of sulfadoxine-pyrimethamine; therefore, careful monitoring will help guide its prolonged usage. Mutations in Plasmodium falciparum dihydropteroate synthas…
View article: Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study
Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study Open
Background Plasmodial transketolase (PTKT) enzyme is one of the novel pharmacological targets being explored as potential anti-malarial drug target due to its functional role and low sequence identity to the human enzyme. Despite this, fea…