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View article: Characterization of the Population, Treatment Patterns, and Outcomes of Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor Mutation (EGFRm): A Retrospective Cohort Study from IPO Porto
Characterization of the Population, Treatment Patterns, and Outcomes of Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor Mutation (EGFRm): A Retrospective Cohort Study from IPO Porto Open
Most patients with non-small-cell lung cancer (NSCLC) present with advanced/metastatic disease at diagnosis, and molecular profiling is critical in guiding treatment decisions. This retrospective cohort study aimed to characterize EGFR mut…
View article: Epidemiological characterization of chronic myeloid leukaemia patients at an oncologic centre: A retrospective observational study
Epidemiological characterization of chronic myeloid leukaemia patients at an oncologic centre: A retrospective observational study Open
This study is the first to characterize chronic myeloid leukaemia patients at a Portuguese centre. The patient characteristics, responses, and overall survival were within the expected range according to the literature. This study confirms…
View article: Short Hydration Regimen in Cisplatin-Based Chemotherapy and Its Impact on Nephrotoxicity: A Unicentric Prospective Study
Short Hydration Regimen in Cisplatin-Based Chemotherapy and Its Impact on Nephrotoxicity: A Unicentric Prospective Study Open
Nephrotoxicity is common when cisplatin is used and hydration during treatment is nephroprotective, but the optimal volume, composition, and duration are unknown. We reviewed our institutional intravenous hydration regimen (total 2500 mL i…
View article: Comparative genomic analyses of aerobic planctomycetes isolated from the deep sea and the ocean surface
Comparative genomic analyses of aerobic planctomycetes isolated from the deep sea and the ocean surface Open
On the deep and dark seafloor, a cryptic and yet untapped microbial diversity flourishes around hydrothermal vent systems. This remote environment of difficult accessibility exhibits extreme conditions, including high pressure, steep tempe…
View article: Utilisation patterns of radiotherapy among older patients: Insights from Portuguese National Cancer Registry data
Utilisation patterns of radiotherapy among older patients: Insights from Portuguese National Cancer Registry data Open
While EBRT is essential for older adults with cancer, disparities and suboptimal utilization highlight opportunities for improving cancer care provision.
View article: “Genome-based in silico assessment of biosynthetic gene clusters in Planctomycetota: Evidences of its wide divergent nature”
“Genome-based in silico assessment of biosynthetic gene clusters in Planctomycetota: Evidences of its wide divergent nature” Open
The biotechnological potential of Planctomycetota only recently started to be unveiled. 129 reference genomes and 5194 available genomes (4988 metagenome-assembled genomes (MAGs)) were analysed regarding the presence of Biosynthetic Gene C…
View article: Real‑world retrospective study of early‑stage prostate cancer at a Portuguese Comprehensive Cancer Centre: The PEarlC study
Real‑world retrospective study of early‑stage prostate cancer at a Portuguese Comprehensive Cancer Centre: The PEarlC study Open
Despite the high prevalence of localised prostate cancer (LPC) and locally advanced prostate cancer (LAPC), evidence on the characteristics of patients, treatments and clinical outcomes stratified by disease risk is limited. The PEarlC stu…
View article: THE RADIOTHERAPY USE BY OLDER CANCER PATIENTS IN PORTUGAL—2018 NATIONAL CANCER REGISTRY DATA
THE RADIOTHERAPY USE BY OLDER CANCER PATIENTS IN PORTUGAL—2018 NATIONAL CANCER REGISTRY DATA Open
In Portugal, cancer is the second leading cause of death, accounting for 28544 in 2018, around 25% of all deaths. Radiotherapy (RT) will be required by around half of the cancer patients. Older patients should be treated with ultrahipofrac…
View article: NONCOMMUNICABLE DISEASES AND HEALTH CARE UTILIZATION: A STUDY OF OLDER ADULTS IN INDIA
NONCOMMUNICABLE DISEASES AND HEALTH CARE UTILIZATION: A STUDY OF OLDER ADULTS IN INDIA Open
Non-communicable diseases (NCDs) have become one of the leading causes of death in India, and it’s more prevalent among aged population. Access to healthcare facilities (HCFs) can reduce this mortality burden considerably. This study addre…
View article: Risk and Survival of Third Primary Cancers in a Population-Based Cohort of Breast Cancer Patients
Risk and Survival of Third Primary Cancers in a Population-Based Cohort of Breast Cancer Patients Open
Introduction: The growing number of women diagnosed with breast cancer (BCa) together with high survival has resulted in an increasing population of survivors at risk of subsequent primary cancers. This study aimed to estimate the long-ter…
View article: The Modulatory Role of Internet-Supported Mindfulness-Based Cognitive Therapy on Extracellular Vesicles and Psychological Distress in People Who Have Had Cancer: A Protocol for A Two-Armed Randomized Controlled Study
The Modulatory Role of Internet-Supported Mindfulness-Based Cognitive Therapy on Extracellular Vesicles and Psychological Distress in People Who Have Had Cancer: A Protocol for A Two-Armed Randomized Controlled Study Open
BackgroundMindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized…
View article: Bacterioplankton Community as a Biological Element for Reservoirs Water Quality Assessment
Bacterioplankton Community as a Biological Element for Reservoirs Water Quality Assessment Open
The Water Framework Directive (WFD) is used to evaluate the water quality of aquatic ecosystems. Phytoplankton is the only biological element considered in the reservoirs water quality assessment. In this study, we aimed to assess the use …
View article: 784 Real-world of ovarian cancer treatment outcomes in Northern Portugal
784 Real-world of ovarian cancer treatment outcomes in Northern Portugal Open
Introduction/Background* Epithelial ovarian cancer (EOC) is the fifth most lethal cancer in women in Portugal. Despite advances in surgical and anti-cancer systemic treatment (SACT), EOC overall prognosis remains poor. The objective of thi…
View article: Assessment of the Safety and Therapeutic Benefits of Convalescent Plasma in COVID-19 Treatment: A Systematic Review and Meta-Analysis
Assessment of the Safety and Therapeutic Benefits of Convalescent Plasma in COVID-19 Treatment: A Systematic Review and Meta-Analysis Open
Background: The coronavirus disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), prompted a global health crisis, with no available specific treatments. Convalescent plasma (CP) with neutralizing …
View article: Anticancer Activity in Planctomycetes
Anticancer Activity in Planctomycetes Open
There is a strong need to develop new drugs against many severe diseases. Therapy resistance is a major problem, for instance, in infectious diseases and cancer. Drug discovery has again turned to nature to search for molecules that can be…
View article: Current Screening Methodologies in Drug Discovery for Selected Human Diseases
Current Screening Methodologies in Drug Discovery for Selected Human Diseases Open
The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on…
View article: Linking microbial community on grapes from two Portuguese wine regions to the biogenic amines production in musts
Linking microbial community on grapes from two Portuguese wine regions to the biogenic amines production in musts Open
\n\t\t\t\tGrapevine-associated microbiota influences wine organoleptic properties. Spoilage due to undesired microorganisms and biogenic amines (BAs) presence are two main constrains that must be seriously considered. In wine, BAs can orig…
View article: Planctomycetes as Novel Source of Bioactive Molecules
Planctomycetes as Novel Source of Bioactive Molecules Open
Marine environments are a fruitful source of bioactive compounds some of which are the newest leading drugs in medicinal therapeutics. Of particular importance are organisms like sponges and macroalgae and their associated microbiome. Plan…