Explanipedia

Long-term cardiovascular events in individuals hospitalised with COVID-19: a retrospective cohort Open

Patrícia Soares, Carolina Ruivinho, Joana Silva, Maria João Lobão, Lèlita Santos , et al. · 2025

Our findings suggest a substantial burden of cardiovascular complications post-COVID-19, underscoring the need for health services to be prepared and commence screening and preventive measures for individuals at higher risk.

Desmoid Tumors: Experience from A Referral Center. Part 1- Multidisciplinary Review and Practical Recommendations Open

Rosa Álvarez, Carolina Agra Pujol, M. Arregui Valles, Francisco Alijo Serrano, A. Gonzalo , et al. · 2025

Desmoid tumors (DTs), also known as aggressive fibromatosis, are rare neoplasms characterized by local invasiveness and a high risk of recurrence, despite their lack of metastatic potential. The management of these tumors remains challengi…

Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories - a EUSTAR study Open

Cécile Trottet, Manuel Schürch, Ahmed E. Allam, L. Petelytska, I. Castellví , et al. · 2025

Variability in percentage reduction of low-density lipoprotein cholesterol per type and intensity of statin therapy among statin naive filipino patients: a retrospective cohort study using dat Open

RAYMOND BANQUIRIGO, Lèlita Santos · 2025

Background Statins, also known as HMG-CoA reductase inhibitors, are one of the most potently prescribed medications, predominantly utilized for managing cardiovascular diseases by modulating serum cholesterol levels including low density c…

NEUROLOGICAL TINNITUS: PATHOPHYSIOLOGICAL MECHANISMS AND THERAPEUTIC APPROACHES Open

Grace Freire, Adriana Cortéz, Horácio Francisco de Medeiros Neto Bosso, Lèlita Santos · 2025

Introduction: Tinnitus is a prevalent auditory disorder characterized by the perception of sound in the absence of external stimuli. While often associated with cochlear pathology, increasing evidence highlights the central nervous system’…

REAL-WORLD OUTCOMES OF ANTI-EGFR RECHALLENGE GUIDED BY LIQUID BIOPSY IN METASTATIC COLORECTAL CANCER Open

Ricardo Roque, Rita Santos, Lèlita Santos, Rita Coelho, Isabel Cristina Ferreira Fernandes , et al. · 2025

INTRODUCTION: In patients with metastatic colorectal cancer (mCRC) without RAS/BRAF somatic variants, first-line anti-EGFR antibodies plus chemotherapy improve survival. Retreatment of responders with anti-EGFR rechallenge accumulates less…

EXPLORANDO A MICROSCOPIA ÓPTICA NO ENSINO DE CITOLOGIA: UM RELATO DE EXPERIÊNCIA NO ENSINO MÉDIO Open

G. Pereira, Ana Catarina de Morais Carvalho, Bruna Silva do Nascimento, Bruno Cardoso dos Santos, João Paulo Costa , et al. · 2025

Outcomes of Broader Genomic Profiling in Metastatic Colorectal Cancer: a Portuguese Cohort Study Open

Ricardo Roque, Rita Santos, Lèlita Santos, Rita Coelho, Isabel Cristina Ferreira Fernandes , et al. · 2024

Background: Colorectal cancer (CRC) is the third most diagnosed cancer globally and the second leading cause of cancer-related deaths. Despite advancements, metastatic CRC (mCRC) has a five-year survival rate below 20%. Next-generation seq…

Structural validity of the Brazilian version of the quality care questionnaire-palliative care for use in individuals with diabetes mellitus eligible for palliative care Open

Arthur Augusto Mendes-Junior, Aldair Darlan Santos‐de‐Araújo, Lèlita Santos, Lorena Lúcia Costa Ladeira, Meire Coelho Ferreira , et al. · 2024

Outcomes of Broader Genomic Profiling in Metastatic Colorectal Cancer: a Portuguese Cohort Study Open

Ricardo Roque, Rita Santos, Lèlita Santos, Rita Coelho, Isabel Cristina Ferreira Fernandes , et al. · 2024

Background: Colorectal cancer (CRC) is the third most diagnosed cancer globally and the second leading cause of cancer-related deaths. Despite advancements, metastatic CRC (mCRC) has a five-year survival rate below 20%. Next-generation seq…

Longitudinal outcomes of obeticholic acid therapy in ursodiol‐nonresponsive primary biliary cholangitis: Stratifying the impact of add‐on fibrates in real‐world practice Open

Elena Góméz, J.L. Montero, Ezequiel Molina, Luisa Garcı́a-Buey, Marta Casado , et al. · 2024

Summary Background Suboptimal response to ursodeoxycholic acid occurs in 40% of primary biliary cholangitis (PBC) patients, affecting survival. Achieving a deep response (normalisation of alkaline phosphatase [ALP] and bilirubin ≤0.6 upper…

Biologische Therapie bei systemischem Lupus erythematodes, Antiphospholipid-Syndrom und Sjögren-Syndrom: evidenz- und praxisbasierte Leitlinien Open

António Marinho, José Delgado Alves, Jorge Luiz Fortuna, Raquel Faria, Isabel Almeida , et al. · 2024

Systemischer Lupus erythematodes (SLE), das Antiphospholipid-Syndrom (APS) und das Sjögren-Syndrom (SS) sind heterogene Autoimmunerkrankungen. Schwere Ausprägungen sowie Therapieresistenz bzw. -unverträglichkeit gegenüber herkömmlichen Imm…

Solvent-Induced Raynaud’s Phenomenon Open

Helena Rodrigues, Catarina Reigota, Carolina Teles, Sónia Moreira, Lèlita Santos · 2023

Asymptomatic Elevation of Pancreatic Enzymes: A Case of Gullo’s Syndrome Open

Guilherme Camões, D. Ferreira, Arsénio Santos, Lèlita Santos · 2023

Comparing Kidney Care during the Pandemic in Hospitalized Non-COVID-19 Patients Open

Ana Rita Silva, Filipe Mira, R. Carrington da Costa, Catarina Reigota, Catarina Romãozinho , et al. · 2023

INTRODUCTION: Coronavirus disease 19 (COVID-19) has caused a direct increase in mortality but not all of it is entirely attributable to COVID-19, meaning there was a higher rate of mortality in non-COVID-19 patients due to the pandemic. Th…

P-301 Benefit of adding bevacizumab to trifluridine/tipiracil in different prognostic groups of metastatic colorectal cancer: A Portuguese exploratory analysis Open

Ricardo Roque, Ana Rita Coelho, Sérgio Brasil, R. Antunes Santos, Lèlita Santos , et al. · 2023

Primary Cardiac Tumor in the Left Atrium: A Diagnostic Challenge Open

Helena Rodrigues, Ana Rita Ramalho, Isabel Correia, R. Ferreira, Lèlita Santos · 2023

Acute kidney injury: a strong risk factor for hypoglycaemia in hospitalized patients with type 2 diabetes Open

Ana Carreira, Pedro Castro, Filipe Mira, Miguel Melo, Pedro Vianna Caldas Ribeiro , et al. · 2023

Aims Acute kidney injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D). We aimed to assess the impact of AKI and its severity and duration on the risk of hypoglycaemia in hospitalized patients with…

Cardiovascular and respiratory events following COVID-19 hospitalisation: a cohort study in Portuguese hospitals Open

Andreia Leite, Maria Brazão, Sofia Nóbrega, Maria João Lobão, Luísa Eça Guimarães , et al. · 2023

Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…

Biological therapy in systemic lupus erythematosus, antiphospholipid syndrome, and Sjögren’s syndrome: evidence- and practice-based guidance Open

António Marinho, José Delgado Alves, Jorge Luiz Fortuna, Raquel Faria, Isabel Almeida , et al. · 2023

Systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and Sjögren’s syndrome (SS) are heterogeneous autoimmune diseases. Severe manifestations and refractory/intolerance to conventional immunosuppressants demand other option…

Rare manifestations of refractory extrapulmonary sarcoidosis Open

Catarina Teles, Carolina Teles, Sónia Moreira, Lèlita Santos · 2023

Sarcoidosis is a multisystemic disease, characterised by histopathologic presence of non-necrotising granulomas, primarily affecting the lungs (>90%). We present three cases predominantly characterised by uncommon extrapulmonary manifestat…

Dysphagia as a presentation of DISH Open

Catarina Reigota, Cátia Barra, Filipe Vilão, Lèlita Santos · 2023

A man in his 70s was referred for an internal medicine consultation with complaints of dysphagia for solid foods and liquids for 3 months, severe weight loss (6 kg in 2 months) and dysphonia for about a year. He had already been evaluated …

Competences of internal medicine specialists for the management of patients with multimorbidity. EFIM multimorbidity working group position paper Open

Máximo Bernabéu-Wittel, Ombretta Para, Jūlija Voicehovska, Ricardo Gómez‐Huelgas, J. Václavík , et al. · 2023

Morvan’s Syndrome: The Importance of Knowing Different Risk-Associated Phenotypes and Antibodies in Identifying the Correct Underlying Tumor Open

Ana Rita Ramalho, José Abreu Fernandes, José T Magalhães, Maria João Rocha, Gonçalo Cunha , et al. · 2023

Paraneoplastic neurologic syndromes (PNS) are neurologic disorders that can affect any part of the nervous system, occur in association with cancer, and have an immune-mediated mechanism that produces direct damage to the neural tissue. Ne…

Impact of COVID-19 Pandemic on In-Hospital Mortality in Patients Without SARS-CoV-2 Infection in an Internal Medicine Ward of a Tertiary Care Hospital in Portugal Open

Ana Rita Ramalho, Ana Cristina Mendes, Guilherme Camões, Ricardo Roque, Pedro Moura , et al. · 2022

The hospital of today. The Oporto consensus Open

Jesús Díez‐Manglano, João Araújo-Correia, Ricardo Gómez‐Huelgas, Lèlita Santos, María Montserrat Chimeno-Viñas , et al. · 2022

The evolution of society has led to big challenges for health-care systems. Sociological, demographic, epidemiological, healthcare, environmental, technological, and economic factors along with the development of innovative health-care tec…

Lymphocyte-Depleted Hodgkin’s Lymphoma in Coeliac Disease: A Diagnostic Challenge During the COVID-19 Pandemic Open

Ana Cristina Mendes, Regina de Lima Costa, Ana Rita Ramalho, Nelson Pedro, Maria José Julião , et al. · 2022

Oportunidades e Desafios da Medicina Interna Open

Lèlita Santos · 2021

Alimentação na Demência Avançada: Documento de Consenso da Sociedade Portuguesa de Medicina Interna e da Associação Portuguesa de Nutrição Entérica e Parentérica Open

Ana Pessoa, Pedro Almeida, Ricardo Marinho, Sofía Duque, Teresa Amaral , et al. · 2021

A demência é uma síndrome neurológica de agravamento progressivo, sem cura, cuja prevalência tem vindo a aumentar devido ao envelhecimento da população. Existe um grande desconhecimento entre profissionais de saúde e cuidadores relativamen…

Impacto da Pandemia COVID-19 na Mortalidade em Serviço de Urgência Open

Helena Rodrigues, Joana Paixão, Rita Costa e Sousa, R. L. Spilker, R. Ferreira , et al. · 2021

Introdução: Dados oficiais revelam que a mortalidade por todas as causas, em Portugal, em 2020 é superior à de 2019. O receio dos doentes de contágio por SARS-CoV-2 condicionou o protelar de avaliações médicas por opção ou imposição e o re…

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