Rita E. Serda
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View article: Clinical translation of TLR agonist-modified silicified cancer cell therapy supported by humanized mouse models
Clinical translation of TLR agonist-modified silicified cancer cell therapy supported by humanized mouse models Open
Humanized patient-derived xenograft (huPDX) mouse models are crucial for evaluating the clinical translation of new immune therapeutics. Silicification of cancer cells renders the cells non-viable with enhanced stability and silica surface…
View article: Rational Design of Immunogenic Nanoparticles as a Platform for Enhanced Ovarian Cancer Immunotherapy in Mice
Rational Design of Immunogenic Nanoparticles as a Platform for Enhanced Ovarian Cancer Immunotherapy in Mice Open
Ovarian cancer immunotherapy remains a challenge based on the “cold” tumor microenvironment. Herein we present a rational design to create immunogenic nanoparticles as a multi-agent platform that promotes immune response in a mouse model o…
View article: Silicified cell replicas, methods of making, and methods of using
Silicified cell replicas, methods of making, and methods of using Open
A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.
View article: Correction: Multivalent Presentation of MPL by Porous Silicon Microparticles Favors T Helper 1 Polarization Enhancing the Anti-Tumor Efficacy of Doxorubicin Nanoliposomes
Correction: Multivalent Presentation of MPL by Porous Silicon Microparticles Favors T Helper 1 Polarization Enhancing the Anti-Tumor Efficacy of Doxorubicin Nanoliposomes Open
[This corrects the article DOI: 10.1371/journal.pone.0094703.].
View article: Regional immune mechanisms enhance efficacy of an autologous cellular cancer vaccine with intraperitoneal administration
Regional immune mechanisms enhance efficacy of an autologous cellular cancer vaccine with intraperitoneal administration Open
Widespread peritoneal dissemination is common in patients with gynecologic or gastrointestinal cancers. Accumulating evidence of a central role for regional immunity in cancer control indicates that intraperitoneal immunotherapy may have t…
View article: TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer
TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer Open
Intraperitoneal (IP) administration of immunogenic mesoporous silica nanoparticles (iMSN) in a mouse model of metastatic ovarian cancer promotes the development of tumor‐specific CD8 + T cells and protective immunity. IP delivery of iMSN f…
View article: 1219 Lipid-coated mesoporous silica nanoparticles (MSN) accumulate selectively in tumor-burdened tissues in a mouse model of serous epithelial ovarian cancer
1219 Lipid-coated mesoporous silica nanoparticles (MSN) accumulate selectively in tumor-burdened tissues in a mouse model of serous epithelial ovarian cancer Open
Background Nanotechnology for drug delivery to cancer cells is hampered by abundant uptake by myeloid cells, with the majority of nanoparticles ending up in filtering organs.1 Kupffer cells or other resident macrophages are the main cells …
View article: 1218 Selective internalization of microbial mimetic mesoporous silica nanoparticles by myeloid-derived suppressor cells with trafficking to tumor-burdened tissues in a mouse model of ovarian cancer
1218 Selective internalization of microbial mimetic mesoporous silica nanoparticles by myeloid-derived suppressor cells with trafficking to tumor-burdened tissues in a mouse model of ovarian cancer Open
Background For the majority of women with ovarian cancer, the disease remains undetectable until later stages, where it is largely uncurable. Fortunately, some patients have experienced remarkable responses to immune therapy. We have fabri…
View article: Specific Tumor Localization of Immunogenic Lipid-Coated Mesoporous Silica Nanoparticles following Intraperitoneal Administration in a Mouse Model of Serous Epithelial Ovarian Cancer
Specific Tumor Localization of Immunogenic Lipid-Coated Mesoporous Silica Nanoparticles following Intraperitoneal Administration in a Mouse Model of Serous Epithelial Ovarian Cancer Open
Immunogenic lipid-coated mesoporous silica nanoparticles (ILM) present pathogen-associated molecular patterns (PAMPs) on the nanoparticle surface to engage pathogen-associated receptors on immune cells. The mesoporous core is capable of lo…
View article: 415 PD-1 immune checkpoint blockade enhances eradication of disseminated ovarian cancer
415 PD-1 immune checkpoint blockade enhances eradication of disseminated ovarian cancer Open
Background Clinical trials for ovarian cancer using immune checkpoint inhibitors (ICI) as monotherapy have failed to show an improvement in survival, however, improved response rates and survival have been achieved with combination therapy…
View article: Monitoring Therapeutic Responses to Silicified Cancer Cell Immunotherapy Using PET/MRI in a Mouse Model of Disseminated Ovarian Cancer
Monitoring Therapeutic Responses to Silicified Cancer Cell Immunotherapy Using PET/MRI in a Mouse Model of Disseminated Ovarian Cancer Open
Current imaging approaches used to monitor tumor progression can lack the ability to distinguish true progression from pseudoprogression. Simultaneous metabolic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) …
View article: A Sampling of Highlights from the Literature
A Sampling of Highlights from the Literature Open
A vaccine targeting resistant tumours by dual T cell
View article: Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways
Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways Open
This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle traffic…
View article: Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells
Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells Open
Macrophages line the walls of microvasculature, extending processes into the blood flow to capture foreign invaders, including nano-scale materials. Using mesoporous silica nanoparticles (MSNs) as a model nano-scale system, we show the int…
View article: Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components
Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components Open
The design and synthesis of artificial materials that mimic the structures, mechanical properties, and ultimately functionalities of biological cells remains a current holy grail of materials science. Here, based on a silica cell bioreplic…
View article: Drug Delivery: Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery (Adv. Mater. 12/2019)
Drug Delivery: Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery (Adv. Mater. 12/2019) Open
A novel and modular super-assembly approach combines the synergistic advantages of metal–organic cage super-assemblies (e.g., highly controlled architecture, high payloads of multiple cargos) and micelles (e.g., low inherent toxicity) for …
View article: Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery
Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery Open
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are describe…
View article: Biotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinoma
Biotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinoma Open
[60]Fullerene is a highly versatile nanoparticle (NP) platform for drug delivery to sites of pathology owing to its small size and both ease and versatility of chemical functionalization, facilitating multisite drug conjugation, drug targe…
View article: Sucrose modulation of radiofrequency-induced heating rates and cell death
Sucrose modulation of radiofrequency-induced heating rates and cell death Open
Sucrose is known to form weak hydrogen bonds in fluids as opposed to ions, freeing water molecules to rotate in an oscillating field of electromagnetic radiation and contributing to heat induction. The ability of cells to survive temporal …