Rita Serrano
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View article: Screening for inhibition of β-haematin formation in Rhaphiostylis beninensis (Hook. f. ex Planch) Planch ex Benth. (Icacinaceae)
Screening for inhibition of β-haematin formation in Rhaphiostylis beninensis (Hook. f. ex Planch) Planch ex Benth. (Icacinaceae) Open
View article: Avaliação da atividade antimalárica e estudo da composição química do extrato de Terminalia sericea raiz
Avaliação da atividade antimalárica e estudo da composição química do extrato de Terminalia sericea raiz Open
Terminalia sericea (Combretaceae) roo, is one of the medicinal plants used in the traditional medicine of the district of Moamba, Maputo province in Mozambique for the treatment of malaria, according to an ethnobotanical survey done by us …
View article: Quality Studies on Cynometra iripa Leaf and Bark as Herbal Medicines
Quality Studies on Cynometra iripa Leaf and Bark as Herbal Medicines Open
Cynometra iripa Kostel. is a Fabaceae species of mangrove used in traditional Ayurvedic medicine for treating inflammatory conditions. The present study aims to establish monographic botanical and chemical quality criteria for C. iripa lea…
View article: Development of an adhesive tablet for the delivery of Diospyros villosa root for the treatment of oral cavity diseases
Development of an adhesive tablet for the delivery of Diospyros villosa root for the treatment of oral cavity diseases Open
The Diospyros villosa root extract (DVR) has the potential to treat oral cavity diseases (DOC), as confirmed by its frequent use as a toothbrush among Mozambicans. In the present work, a tablet with adhesive properties was developed with p…
View article: Biallelic variants in<i>HMGCS1</i>are a novel cause of rare rigid spine syndrome
Biallelic variants in<i>HMGCS1</i>are a novel cause of rare rigid spine syndrome Open
Rigid spine syndrome is a rare childhood-onset myopathy characterised by slowly progressive or non-progressive scoliosis, neck and spine contractures, hypotonia, and respiratory insufficiency. Biallelic variants in SELENON account for most…
View article: Quality, Safety and Biological Studies on Campylanthus glaber Aerial Parts
Quality, Safety and Biological Studies on Campylanthus glaber Aerial Parts Open
In Cabo Verde, several endemic species are used in traditional medicine. However, no scientific studies have been conducted on the quality, efficacy, and safety of most of these plants. This study focused on establishing the botanical and …
View article: The Genus Diospyros: A Review of Novel Insights into the Biological Activity and Species of Mozambican Flora
The Genus Diospyros: A Review of Novel Insights into the Biological Activity and Species of Mozambican Flora Open
Species of the Diospyros L. genus (Ebenaceae family) have been largely used in traditional medicine for the treatment of several diseases, especially infectious ones. To date, active major compounds such as naphthoquinones, triterpenoids, …
View article: Bioguided Identification of Active Antimicrobial Compounds from Asphodelus bento-rainhae and Asphodelus macrocarpus Root Tubers
Bioguided Identification of Active Antimicrobial Compounds from Asphodelus bento-rainhae and Asphodelus macrocarpus Root Tubers Open
Root tubers of Asphodelus bento-rainhae subsp. bento-rainhae (AbR), a vulnerable endemic species, and Asphodelus macrocarpus subsp. macrocarpus (AmR) have traditionally been used in Portugal to treat inflammatory and infectious skin disord…
View article: Vernonia britteniana Root Phytochemical Studies, In Vitro Cercaricidal Activity on the Larval Stage of Schistosoma mansoni and Antioxidant Activities
Vernonia britteniana Root Phytochemical Studies, In Vitro Cercaricidal Activity on the Larval Stage of Schistosoma mansoni and Antioxidant Activities Open
Vernonia britteniana Hiern. (Asteraceae) is a medicinal plant used in traditional Angolan medicine against schistosomiasis. Our study aimed to investigate the phytochemical composition and the cercaricidal and antioxidant activities in vit…
View article: Identification of Marker Compounds and In Vitro Toxicity Evaluation of Two Portuguese Asphodelus Leaf Extracts
Identification of Marker Compounds and In Vitro Toxicity Evaluation of Two Portuguese Asphodelus Leaf Extracts Open
The leaves of Asphodelus bento-rainhae subsp. bento-rainhae, an endemic Portuguese species, and Asphodelus macrocarpus subsp. macrocarpus have been used as food, and traditionally as medicine, for treating ulcers, urinary tract, and inflam…
View article: Hypericum foliosum Quality Botanical and Chemical Markers and In Vitro Antioxidant and Anticancer Activities
Hypericum foliosum Quality Botanical and Chemical Markers and In Vitro Antioxidant and Anticancer Activities Open
Hypericum foliosum Aiton is an endemic Azorean Hypericum species. Even though the aerial parts of Hypericum foliosum are not described in any official pharmacopoeia, they are utilized in local traditional medicine due to their diuretic, he…
View article: Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorindeia juglandifolia Leaves Open
Dried leaves of Lannea velutina A. Rich. and Sorindeia juglandifolia (A. Rich.) Planch. ex Oliv. (family Anacardiaceae) are used in African traditional medicine. Although these medicinal plants have widespread use in the treatment of infla…
View article: Micromorphology and Chemical Studies on Anacardium occidentale L. Stem Bark as an Herbal Medicine
Micromorphology and Chemical Studies on Anacardium occidentale L. Stem Bark as an Herbal Medicine Open
The red and white types of Anacardium occidentale L. stem barks (AoB) are used in the Community of Portuguese Language Countries, including Portugal, to make traditional herbal preparations for the treatment of diabetes. This work aims to …
View article: The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data
The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data Open
Cynometra L. is a Fabaceae genus that is widely distributed throughout the tropics, consisting of tropical forest trees with ecological and economic importance since they are used as food and herbal medicines by the populations of their na…
View article: Diospyros villosa Root Monographic Quality Studies
Diospyros villosa Root Monographic Quality Studies Open
Diospyros villosa L. (De Winter) (Ebenaceae) is a shrub whose root (DVR) is used as a toothbrush and to treat oral infections in Mozambique. The present work aims at establishing monographic quality criteria to allow the sustainable and sa…
View article: Monographic Quality Parameters and Genotoxicity Assessment of Asphodelus bento-rainhae and Asphodelus macrocarpus Root Tubers as Herbal Medicines
Monographic Quality Parameters and Genotoxicity Assessment of Asphodelus bento-rainhae and Asphodelus macrocarpus Root Tubers as Herbal Medicines Open
Root tubers of Asphodelus bento-rainhae subsp. bento-rainhae (AbR), an endemic species with relevant interest due to conservation concerns, and Asphodelus macrocarpus subsp. macrocarpus (AmR) have been traditionally used for culinary and m…
View article: Hypericum Genus as a Natural Source for Biologically Active Compounds
Hypericum Genus as a Natural Source for Biologically Active Compounds Open
Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression,…
View article: First person – Rita Serrano
First person – Rita Serrano Open
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Rita Serrano is first author on ‘ …
View article: Figure S1
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Raw and supporting data for Figure S1 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Figure 2
Figure 2 Open
Raw and supporting data for Figure 2 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Figure 5
Figure 5 Open
Raw and supporting data for Figure 5 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Figure S4
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Raw and supporting data for Figure S4 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology
View article: Figure S3
Figure S3 Open
Raw and supporting data for Figure S3 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Figure 3
Figure 3 Open
Raw and supporting data for Figure 3 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Metformin rescues muscle function in BAG3 myofibrillar myopathy models
Metformin rescues muscle function in BAG3 myofibrillar myopathy models Open
Dominant de novo mutations in the co-chaperone BAG3 cause a severe form of myofibrillar myopathy, exhibiting progressive muscle weakness, muscle structural failure, and protein aggregation. To elucidate the mechanism of disease in, …
View article: Figure 4
Figure 4 Open
Raw and supporting data for Figure 4 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Figure 6
Figure 6 Open
Raw and supporting data for Figure 6 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Figure S2
Figure S2 Open
Raw and supporting data for Figure S2 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.
View article: Figure S5
Figure S5 Open
Raw and supporting data for Figure S5 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology
View article: Figure S6
Figure S6 Open
Raw and supporting data for Figure S6 in Genetic model of UBA5 deficiency highlights involvement of both peripheral and central nervous systems and identifies widespread mitochondrial pathology.