Explanipedia

<span>EBNEO</span> Commentary: Late Permissive Hypercapnia for Mechanically Ventilated Preterm Infants Open

Thomas M. Raffay, Rita M. Ryan · 2025

Hereditary Spherocytosis: Review of Presentation at Birth Open

Nadine-Stella Achenjang, Elizabeth Jadczak, Rita M. Ryan, Mary Nock · 2025

Background/Objectives: We wished to raise awareness of Hereditary Spherocytosis (HS) as a potential cause of early and significant hemolytic newborn jaundice. Methods: We utilized three recent cases from our experience to discuss hyperbili…

Small for gestational age infants achieve physiologic milestones related to discharge at a later postmenstrual age Open

Adriana Hoffman, Sarah Ronis, Rita M. Ryan · 2024

Postnatal corticosteroid therapy in bronchopulmonary dysplasia - why animal studies disagree with clinical trials? Open

Anantha Harijith, Thomas M. Raffay, Rita M. Ryan · 2024

The systematic review and meta-analysis of newborn animal models by Irene Lok et al. is the first to extensively summarize the literature regarding postnatal systemic corticosteroid use on lung development of newborn rodent models. The met…

Predicting iatrogenic adrenal insufficiency in neonates exposed to prolonged steroid courses: do cortisol levels help? Open

Kristen Rosano, Saya Bery, Jaime Marasch, Ryan Farrell, Lucy D. Mastrandrea , et al. · 2024

Objective To determine whether random cortisol levels obtained in neonates to assess for secondary adrenal insufficiency (AI) after prolonged steroid exposure are predictive of central AI. Study design Data were collected on neonates born …

The spectrum of pneumonia among intubated neonates in the neonatal intensive care unit Open

Dayle J. Bondarev, Rita M. Ryan, Devashis Mukherjee · 2024

Efficacy of erythropoietin for the late treatment of anemia of prematurity in a level IV neonatal intensive care unit: A retrospective single-center cohort study Open

Jillian Connolly, Jaime Marasch, Jacquelyn D. McClary, R K Desai, Anupama Sundaram , et al. · 2024

Objective To determine the average change in hematocrit (Hct) after erythropoietin administration for the treatment of anemia of prematurity and describe the population in which erythropoietin is being utilized. Study Design This retrospec…

Assessing the Utility of Cortisol Levels in Predicting Iatrogenic Adrenal Insufficiency in Neonates Exposed to Prolonged Steroid Courses Open

Kristen Rosano, Saya Bery, Jaime Marasch, Ryan Farrell, Lucy D. Mastrandrea , et al. · 2023

Objective To determine whether random cortisol levels obtained in neonates to assess for secondary adrenal insufficiency (AI) after prolonged steroid exposure are predictive of central AI. Study Design: Data were collected on neonates born…

P03.15.B SURGICALLY TARGETED RADIATION THERAPY (START) FOR RECURRENT GLIOBLASTOMA: INITIAL OUTCOMES FROM A PROSPECTIVE MULTICENTER REGISTRY Open

Ahmad Ozair, Colette J. Shen, S Lee, Hoang Pham, Roukoz Chamoun , et al. · 2023

BACKGROUND Surgically targeted radiation therapy (STaRT), using a novel bioresorbable collagen brachytherapy device containing 4 Cesium-131 sources, is FDA-cleared for use as adjuvant radiation therapy (RT) post-resection in both newly dia…

The Pandemic Allocation of Ventilators Model Penalizes Infants with Bronchopulmonary Dysplasia Open

Anupama Sundaram, Jonathan M. Fanaroff, Deanne Wilson-Costello, Melissa Alberts, Naini Shiswawala , et al. · 2023

During the COVID-19 pandemic, institutions developed ventilator allocation models. In one proposed model, neonates compete with adults for ventilators using a scoring system. Points are given for conditions that increase one- and five-year…

Infrared light elicits endothelium-dependent vasodilation in isolated occipital arteries of the rat via soluble guanylyl cyclase-dependent mechanisms Open

Tristan H. Lewis, Junqi Zhuo, Jacob X. McClellan, Paulina M. Getsy, Rita M. Ryan , et al. · 2023

The left and right occipital arteries provide blood supply to afferent cell bodies in the ipsilateral nodose and petrosal ganglia. This supply is free of an effective blood-ganglion barrier, so changes in occipital artery blood flow direct…

RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS Open

Vineet Bhandari, Rachel Black, Bheru B. Gandhi, S. Hogue, Venkatakrishna Kakkilaya , et al. · 2023

Evaluation of Intravenous Immunoglobulin Administration for Hyperbilirubinemia in Newborn Infants with Hemolytic Disease Open

Daniel R. Mohan, Hannah Lu, Jacquelyn D. McClary, Jaime Marasch, Mary Nock , et al. · 2023

The primary objective of this research was to evaluate the use of intravenous immunoglobulin (IVIG) in infants with hemolytic disease, to assess compliance with the American Academy of Pediatrics (AAP) guideline recommendations, and to rev…

The ventilatory depressant actions but not the antinociceptive effects of morphine are blunted in rats receiving intravenous infusion of L-cysteine ethyl ester Open

Tristan H. Lewis, Walter J. May, Alex P. Young, James N. Bates, Santhosh M. Baby , et al. · 2022

This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine ethyl ester (L-CYSee), to adult male Sprague-Dawley rats elicited (a) minor alterations in frequency of breathing, expiratory time, tidal volum…

How much does a minimum weight at discharge delay discharge from the neonatal intensive care unit? Open

R K Desai, Monika Bhola, Sarah Ronis, Rita M. Ryan · 2022

Objective: Determine if discharge at physiologic maturity (PM) (based on national guidelines) even if <1800g, the minimum weight for discharge at our institution, will decrease hospital days (HD). Methods: We reviewed 129 infants with birt…

Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue Open

Danforth A. Newton, Robyn G. Lottes, Rita M. Ryan, Demetri D. Spyropoulos, John E. Baatz · 2021

Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells Open

Rita M. Ryan, Manjeet K. Paintlia, Danforth A. Newton, Demetri D. Spyropoulos, Matthew W. Kemp , et al. · 2021

Atrial natriuretic peptide (ANP) and its receptors natriuretic peptide receptor (NPR)-A and NPR-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late-gestation ovine fetal lung and are dramatically decreased p…

A predictive model for preterm babies born < 30 weeks gestational age who will not attain full oral feedings Open

Daniel B. Gehle, Alison Chapman, Mathew J. Gregoski, Meghan Brunswick, Emily Anderson , et al. · 2021

Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm Infants Open

Siamak Yazdi, Ekta Patel, Colby D. Richardson, Karen Hardy, John E. Baatz , et al. · 2021

Postnatal corticosteroids improve respiratory status and facilitate respiratory support weaning in preterm infants with bronchopulmonary dysplasia (BPD). Older literature describes characteristic cytokine profiles in tracheal aspirates (TA…

Characterization of endothelium-dependent and -independent processes in occipital artery of the rat: relevance to control of blood flow to nodose sensory cells Open

Tristan H. Lewis, Paulina M. Getsy, John F. Peroni, Rita M. Ryan, Michael W. Jenkins , et al. · 2021

This study demonstrates that the endothelium-dependent regulation of smooth muscle tone of occipital arteries is segment-dependent. Endothelial cells at the occipital artery-external carotid artery junction (entryway of blood flow to the n…

E-063 Novel use of an ekosonic™ (EKOS) endovascular system as rescue therapy in the treatment of a highly refractory cerebral venous sinus thrombosis Open

Nicole Vivelo, Rita M. Ryan, Rene O. Sanchez-Mejia · 2021

Introduction Endovascular treatment for cerebral venous sinus thrombosis (CVST) is typically considered a rescue therapy in management of patients with clinical deterioration or progression of intracranial hemorrhage/venous infarct despite…

Introducing Less-Invasive Surfactant Administration into a Level IV NICU: A Quality Improvement Initiative Open

Steven M Conlon, Allison Osborne, Julie Bodie, Jaime Marasch, Rita M. Ryan , et al. · 2021

Less-invasive surfactant administration (LISA), a newer technique of delivering surfactant via a thin catheter, avoids mechanical ventilation. LISA has been widely adopted in Europe but less so in the US. Our goal was to increase the perce…

Severity of respiratory disease is correlated with time of first oral feeding and need for a gastrostomy tube at discharge in premature infants born at <30 weeks of gestation Open

Emily Anderson, Matthew Gregoski, Daniel B. Gehle, William T. Head, Thomas Hardy , et al. · 2021

Background: Premature infants who cannot achieve full oral feeds may need a gastrostomy tube (GT) to be discharged from the neonatal intensive care unit (NICU). We previously developed a model to predict which infants born <30 weeks (w) ge…

Postnatal steroid management in preterm infants with evolving bronchopulmonary dysplasia Open

Zeyar Htun, Elizabeth V. Schulz, R K Desai, Jaime Marasch, Christopher McPherson , et al. · 2021

Journal of Perinatology Editorial Updates 2021 Open

Tonse N.K. Raju, Yvonne W. Cheng, Francis B. Mimouni, Stephen A. Pearlman, Rita M. Ryan , et al. · 2021

Molecular Mechanisms of Maternal Diabetes Effects on Fetal and Neonatal Surfactant Open

Hilal Yildiz Atar, John E. Baatz, Rita M. Ryan · 2021

Respiratory distress is a significant contributor to newborn morbidity and mortality. An association between infants of diabetic mothers (IDMs) and respiratory distress syndrome (RDS) has been well recognized for decades. As obesity and di…

Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome Open

Arielle L. Olicker, Thomas M. Raffay, Rita M. Ryan · 2021

Infants born through meconium-stained amniotic fluid (MSAF) are 100 times more likely than infants born through clear amniotic fluid to develop respiratory distress in the neonatal period. Meconium aspiration syndrome (MAS) is a common cau…

Genetic Testing for Neonatal Respiratory Disease Open

Lawrence M. Nogee, Rita M. Ryan · 2021

Genetic mechanisms are now recognized as rare causes of neonatal lung disease. Genes potentially responsible for neonatal lung disease include those encoding proteins important in surfactant function and metabolism, transcription factors i…

Lymphocyte-Specific Biomarkers Associated With Preterm Birth and Bronchopulmonary Dysplasia Open

Soumyaroop Bhattacharya, Jared A. Mereness, Andrea Baran, Ravi Misra, Derick R. Peterson , et al. · 2021

Many premature babies who are born with neonatal respiratory distress syndrome (RDS) go on to develop Bronchopulmonary Dysplasia (BPD) and later Post-Prematurity Respiratory Disease (PRD) at one year corrected age, characterized by persist…

Lymphocyte-Specific Biomarkers Associated with Preterm Birth and Bronchopulmonary Dysplasia Open

Soumyaroop Bhattacharya, Jared A. Mereness, Andrea Baran, Ravi Misra, Derick R. Peterson , et al. · 2020

Many premature babies who are born with neonatal respiratory distress syndrome (RDS) go on to develop Bronchopulmonary Dysplasia (BPD) and later Post-Prematurity Respiratory Disease (PRD) at one year corrected age, characterized by persist…

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