Rita Manco
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View article: Endothelial c-Maf prevents MASLD-like liver fibrosis by regulating chromatin accessibility to suppress pathogenic microvascular cell subsets
Endothelial c-Maf prevents MASLD-like liver fibrosis by regulating chromatin accessibility to suppress pathogenic microvascular cell subsets Open
This work builds on the known importance of liver sinusoidal endothelial cells in liver function and disease. Here, transcription factor c-Maf is identified as a master regulator in maintaining normal differentiation and zonation of liver …
View article: Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish Open
The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. This paradigm is well-documented for adul…
View article: Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes’ fate in chronic liver disease
Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes’ fate in chronic liver disease Open
Summary In chronic liver disease (CLD), hepatocyte senescence limits conventional regeneration, prompting an alternative regeneration mechanism through transdifferentiation of reactive cholangiocytes (or ductular reaction cells - DRs). Yet…
View article: Vascular damage and excessive proliferation compromise liver function after extended hepatectomy in mice
Vascular damage and excessive proliferation compromise liver function after extended hepatectomy in mice Open
Background and Aims: Surgical resection remains the gold standard for liver tumor treatment, yet the emergence of postoperative liver failure, known as the small-for-size syndrome (SFSS), poses a significant challenge. The activation of hy…
View article: Vascular damage and excessive proliferation compromise liver function after extended hepatectomy in mice
Vascular damage and excessive proliferation compromise liver function after extended hepatectomy in mice Open
Surgical resection remains the gold standard for liver tumor treatment, yet the emergence of post-operative liver failure, known as the small for size syndrome (SFSS), poses a substantial challenge. The activation of hypoxia sensors in a S…
View article: P032 Host transcriptome signatures in human fecal-washes predict histological remission in IBD patients
P032 Host transcriptome signatures in human fecal-washes predict histological remission in IBD patients Open
Background Colonoscopy is the gold standard for evaluation of inflammation in inflammatory bowel diseases (IBD), yet entails cumbersome preparations and risks of injury. Existing non-invasive prognostic tools are limited in their diagnosti…
View article: The spatio-temporal program of liver zonal regeneration
The spatio-temporal program of liver zonal regeneration Open
Summary The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-cell approaches are necessary to study this process, given the spatial heterogeneity of multiple liver cell types. Here, we use spatially…
View article: Dissociation of Jejunum cells for clumps sorting v1
Dissociation of Jejunum cells for clumps sorting v1 Open
Single-cell RNA sequencing combined with spatial information on landmark genes enables the reconstruction of spatially-resolved tissue cell atlases. However, such approaches are challenging for rare cell types since their mRNA contents are…
View article: Clump sequencing exposes the spatial expression programs of intestinal secretory cells
Clump sequencing exposes the spatial expression programs of intestinal secretory cells Open
Single-cell RNA sequencing combined with spatial information on landmark genes enables reconstruction of spatially-resolved tissue cell atlases. However, such approaches are challenging for rare cell types, since their mRNA contents are di…
View article: Clump sequencing exposes the spatial expression programs of intestinal secretory cells
Clump sequencing exposes the spatial expression programs of intestinal secretory cells Open
Single-cell RNA sequencing combined with spatial information on landmark genes enables reconstruction of spatially-resolved tissue cell atlases. However, such approaches are challenging for rare cell types, since their mRNA contents are di…
View article: Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism
Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism Open
Diverse metabolic disorders have been associated with an alteration of N-acylethanolamine (NAE) levels. These bioactive lipids are synthesized mainly by N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and influence host…
View article: Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment
Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment Open
Liver regeneration is crucial for the maintenance of liver functional mass during homeostasis and diseases. In a disease context-dependent manner, liver regeneration is contributed to by hepatocytes or progenitor cells. As long as they are…
View article: Relevance of the CDE and DDC Mouse Models to Study Ductular Reaction in Chronic Human Liver Diseases
Relevance of the CDE and DDC Mouse Models to Study Ductular Reaction in Chronic Human Liver Diseases Open
The liver has the remarkable capacity to regenerate through cellular division of hepatocytes. However, following severe injuries that abrogates the replicative capacity of hepatocytes some immature-like cells proliferate around the portal …
View article: Upstream regulators of hepatic Wnt/β‐catenin activity control liver metabolic zonation, development, and regeneration
Upstream regulators of hepatic Wnt/β‐catenin activity control liver metabolic zonation, development, and regeneration Open
Clerbaux, Laure‐Alix Ph.D.; Manco, Rita M.Sc.; Leclercq, Isabelle M.D., Ph.D. Author Information
View article: Multifunctional Polymer Nanofibers: UV Emission, Optical Gain, Anisotropic Wetting, and High Hydrophobicity for Next Flexible Excitation Sources
Multifunctional Polymer Nanofibers: UV Emission, Optical Gain, Anisotropic Wetting, and High Hydrophobicity for Next Flexible Excitation Sources Open
The use of UV light sources is highly relevant in many fields of science, being directly related to all those detection and diagnosis procedures that are based on fluorescence spectroscopy. Depending on the specific application, UV light-e…
View article: Metal-Enhanced Near-Infrared Fluorescence by Micropatterned Gold Nanocages
Metal-Enhanced Near-Infrared Fluorescence by Micropatterned Gold Nanocages Open
In metal-enhanced fluorescence (MEF), the localized surface plasmon resonances of metallic nanostructures amplify the absorption of excitation light and assist in radiating the consequent fluorescence of nearby molecules to the far-field. …
View article: Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment Open
In many organs, including the intestine and skin, cancers originate from cells of the stem or progenitor compartment. Despite its nomenclature, the cellular origin of hepatocellular carcinoma (HCC) remains elusive. In contrast to most orga…