Rita Moretti
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View article: The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review
The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review Open
Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concernin…
View article: Level of education and mortality in the vulnerable period following an acute heart failure hospitalization
Level of education and mortality in the vulnerable period following an acute heart failure hospitalization Open
Introduction Patients hospitalized for acute heart failure (HF) are at increased risk of death in the early post-discharge period, so-called the "vulnerable period" (1). Post-discharge treatment strategies can help improve outcomes, but th…
View article: The Gut-Liver-Brain Axis: From the Head to the Feet
The Gut-Liver-Brain Axis: From the Head to the Feet Open
The gut-liver-brain axis, a multifaceted network of communication, intricately connects the enteric, hepatic, and central nervous systems [...]
View article: Gut Microbes Meet Machine Learning: The Next Step towards Advancing Our Understanding of the Gut Microbiome in Health and Disease
Gut Microbes Meet Machine Learning: The Next Step towards Advancing Our Understanding of the Gut Microbiome in Health and Disease Open
The human gut microbiome plays a crucial role in human health and has been a focus of increasing research in recent years. Omics-based methods, such as metagenomics, metatranscriptomics, and metabolomics, are commonly used to study the gut…
View article: Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation
Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation Open
Celiac disease (CD) is a complex multi-organ disease with a high prevalence of extra-intestinal involvement, including neurological and psychiatric manifestations, such as cerebellar ataxia, peripheral neuropathy, epilepsy, headache, cogni…
View article: Bilirubin Prevents the TH+ Dopaminergic Neuron Loss in a Parkinson’s Disease Model by Acting on TNF-α
Bilirubin Prevents the TH+ Dopaminergic Neuron Loss in a Parkinson’s Disease Model by Acting on TNF-α Open
Parkinson’s disease (PD), the fastest-growing movement disorder, is still challenged by the unavailability of disease-modifying therapy. Mildly elevated levels of unconjugated bilirubin (UCB, PubChem CID 5280352) have been shown to be prot…
View article: Predictors of Hepatocellular Carcinoma Early Recurrence in Patients Treated with Surgical Resection or Ablation Treatment: A Single-Center Experience
Predictors of Hepatocellular Carcinoma Early Recurrence in Patients Treated with Surgical Resection or Ablation Treatment: A Single-Center Experience Open
Introduction: Hepatocellular carcinoma (HCC) is the sixth most diagnosed malignancy and the fourth leading cause of cancer-related death worldwide, with poor overall survival despite available curative treatments. One of the most crucial f…
View article: Nonalcoholic Fatty Liver Disease and Altered Neuropsychological Functions in Patients with Subcortical Vascular Dementia
Nonalcoholic Fatty Liver Disease and Altered Neuropsychological Functions in Patients with Subcortical Vascular Dementia Open
NAFLD is the most common cause of abnormality in liver function tests. NAFLD is considered a potential cardiovascular risk factor and is linked to cardiovascular risk factors such as obesity, hypertension, type 2 diabetes, and dyslipidemia…
View article: Common Shared Pathogenic Aspects of Small Vessels in Heart and Brain Disease
Common Shared Pathogenic Aspects of Small Vessels in Heart and Brain Disease Open
Small-vessel disease (SVD), also known as microvascular endothelial dysfunction, is a disorder with negative consequences for various organs such as the heart and brain. Impaired dilatation and constriction of small vessels in the heart le…
View article: Small Vessel Disease: Ancient Description, Novel Biomarkers
Small Vessel Disease: Ancient Description, Novel Biomarkers Open
Small vessel disease (SVD) is one of the most frequent pathological conditions which lead to dementia. Biochemical and neuroimaging might help correctly identify the clinical diagnosis of this relevant brain disease. The microvascular alte…
View article: Antibiotics and Liver Cirrhosis: What the Physicians Need to Know
Antibiotics and Liver Cirrhosis: What the Physicians Need to Know Open
The liver is the primary site of drug metabolism, which can be altered by a variety of diseases affecting the liver parenchyma, especially in patients with liver cirrhosis. The use of antibiotics in patients with cirrhosis is usually a mat…
View article: Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders
Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders Open
Hepatitis C Virus (HCV), despite being a hepatotropic virus, is the causative agent of many systemic disorders, such as vasculitis, autoimmune diseases, lymphoproliferative disorders, and a broad spectrum of neurological and psychiatric ma…
View article: Calprotectin and SARS-CoV-2: A Brief-Report of the Current Literature
Calprotectin and SARS-CoV-2: A Brief-Report of the Current Literature Open
In late December 2019, a novel coronavirus (lately referred to as SARS-CoV-2) spread in the city of Wuhan, China, causing an outbreak of unusual viral pneumonia. In many people, the disease is mild and self-limiting, but in a considerable …
View article: COVID-19 Lockdown Effect on Not Institutionalized Patients with Dementia and Caregivers
COVID-19 Lockdown Effect on Not Institutionalized Patients with Dementia and Caregivers Open
SARS-COV-2 is a severe medical condition. Old patients are very vulnerable, but they have been studied only as institutionalized patients. During the lock-down, little attention is dedicated to old, demented patients who lived at home. Thi…
View article: Bilirubin: A Promising Therapy for Parkinson’s Disease
Bilirubin: A Promising Therapy for Parkinson’s Disease Open
Following the increase in life expectancy, the prevalence of Parkinson’s disease (PD) as the most common movement disorder is expected to rise. Despite the incredibly huge efforts in research to find the definitive biomarker, to date, the …
View article: Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease
Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease Open
Homocysteine (Hcy) is a sulfur-containing amino acid generated during methionine metabolism, accumulation of which may be caused by genetic defects or the deficit of vitamin B12 and folate. A serum level greater than 15 micro-mols/L is def…
View article: Curcumin Prevents Cerebellar Hypoplasia and Restores the Behavior in Hyperbilirubinemic Gunn Rat by a Pleiotropic Effect on the Molecular Effectors of Brain Damage
Curcumin Prevents Cerebellar Hypoplasia and Restores the Behavior in Hyperbilirubinemic Gunn Rat by a Pleiotropic Effect on the Molecular Effectors of Brain Damage Open
Bilirubin toxicity to the central nervous system (CNS) is responsible for severe and permanent neurologic damage, resulting in hearing loss, cognitive, and movement impairment. Timely and effective management of severe neonatal hyperbiliru…
View article: From Brain to Heart: Possible Role of Amyloid-β in Ischemic Heart Disease and Ischemia-Reperfusion Injury
From Brain to Heart: Possible Role of Amyloid-β in Ischemic Heart Disease and Ischemia-Reperfusion Injury Open
Ischemic heart disease (IHD) is among the leading causes of death in developed countries. Its pathological origin is traced back to coronary atherosclerosis, a lipid-driven immuno-inflammatory disease of the arteries that leads to multifoc…
View article: You Talking to Me? Says the Enteric Nervous System (ENS) to the Microbe. How Intestinal Microbes Interact with the ENS
You Talking to Me? Says the Enteric Nervous System (ENS) to the Microbe. How Intestinal Microbes Interact with the ENS Open
Mammalian organisms form intimate interfaces with commensal and pathogenic gut microorganisms. Increasing evidence suggests a close interaction between gut microorganisms and the enteric nervous system (ENS), as the first interface to the …
View article: Homocysteine in Neurology: A Risk Factor or Something Different in Small Vessel Disease
Homocysteine in Neurology: A Risk Factor or Something Different in Small Vessel Disease Open
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metabolism. Hyperhomocysteinemia (HHcy) is typically defined as levels >15 micro mols/L. Elevated plasma levels of Hcy can be caused by the deficie…
View article: An Iatrogenic Model of Brain Small-Vessel Disease: Post-Radiation Encephalopathy
An Iatrogenic Model of Brain Small-Vessel Disease: Post-Radiation Encephalopathy Open
We studied 114 primitive cerebral neoplasia, that were surgically treated, and underwent radiotherapy (RT), and compared their results to those obtained by 190 patients diagnosed with subcortical vascular dementia (sVAD). Patients with any…
View article: Bilirubin and inflammation in neurodegenerative and other neurological diseases
Bilirubin and inflammation in neurodegenerative and other neurological diseases Open
Inflammation links neurodegenerative, neuropsychiatric and other neurological diseases (NDs) with acute brain events. It is responsible for the alteration of neurotransmission and circuity, brain architecture, and cell fate, affecting mood…
View article: Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?
Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling? Open
The arteriosclerosis-dependent alteration of brain perfusion is one of the major determinants in small vessel disease, since small vessels have a pivotal role in the brain’s autoregulation. Nevertheless, as far as we know, endothelium dist…
View article: B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?
B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia? Open
Many studies have been written on vitamin supplementation, fatty acid, and dementia, but results are still under debate, and no definite conclusion has yet been drawn. Nevertheless, a significant amount of lab evidence confirms that vitami…
View article: Small vessel disease to subcortical dementia: a dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit
Small vessel disease to subcortical dementia: a dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit Open
Paola Caruso, Riccardo Signori, Rita MorettiDepartment of Medical, Surgical and Health Sciences, Neurology Clinic, University of Trieste, Trieste, ItalyBackground: Small vessels have the pivotal role for the brain’s autoregulation. The art…