Explanipedia

Awareness and perception of invasive fungal diseases among the Nigerian population Open

Olufunmilola Makanjuola, Ubong Udoh, Damilola Akinlawon, Folasade Ogunsola, Rita Oladele · 2025

Background: Invasive fungal diseases (IFDs) are a public health issue causing morbidity and mortality in millions annually, yet they remain under-recognised. Aim: To determine the awareness and perception of IFDs among Nigerians. Setting: …

Molecular identification and antifungal susceptibility testing of Aspergillus species among patients with chronic pulmonary aspergillosis in Nigeria Open

Adeyinka A. Davies, Bram Spruijtenburg, Eelco F. J. Meijer, Iriagbonse I. Osaigbovo, Oluwaseyi Jessy Balogun , et al. · 2025

Background: Triazole resistance in Aspergillus spp. has therapeutic implications for managing chronic pulmonary aspergillosis (CPA) worldwide. However, antifungal susceptibility testing (AFST) is not routinely performed in Nigeria, a count…

Fungal contamination of commercial drinking water in Lagos, Nigeria Open

Kolapo Solomon Olawale, Folasade Ogunsola, Rebecca F. Peters, Bassey E. Ekeng, Omar Lateef , et al. · 2025

Purpose: Water deemed fit for consumption ought to conform to minimum standards that pose no significant health risk to the consumers. Bottled and Sachet water constitutes the major source of drinking water in, Lagos State Nigeria. We cond…

Comparative evaluation of the clinical effectiveness of chemomechanical (Papacarie) and conventional mechanical caries removal methods in treatment of carious primary molars: a randomized controlled clinical study Open

Bimbola Opeyemi Akindele, O O Orenuga, Olubukola O. Olatosi, Rita Oladele · 2025

Pan African Clinical Trial Registry (PACTR) Trial number PACTR202111738486539. Registered 18th November 2021.

Evaluation of the LDBio ICT IgG/IgM lateral flow assay versus the Bordier Elisa assay for the diagnosis of chronic pulmonary aspergillosis in Nigeria Open

Oluwaseyi Jessy Balogun, Rita Oladele, O.O.E. Ajibola, Adelina A. Davies, T.A. Fashanu , et al. · 2025

The detection of anti- Aspergillus antibodies is key for diagnosing chronic pulmonary aspergillosis (CPA). Available techniques are limited and pose a considerable challenge in resource-limited settings. The objective of this study was to …

Advancing Patient Advocacy in Mycology: Cultivating Collaboration in Education, Research, and Policy Open

Rob Purdie, Rasha Kuran, Ana Alastruey‐Izquierdo, Hatim Sati, Juan L. Rodríguez‐Tudela , et al. · 2025

Implementation of the advanced HIV disease package of care using a public health approach: lessons from Nigeria Open

Williams Eigege, Oche Agbaji, Nere Otubu, Opeyemi Abudiore, Oluwakemi Sowale , et al. · 2024

Diagnostic Capacity for Fungal Infections in Tertiary Hospitals in Nigeria and Ghana - An Onsite Baseline Audit of 9 Sites Open

Damilola Akinlawon, Iriagbonse I. Osaigbovo, Mohammed Yahaya, Olufunmilola Makanjuola, Ubong Udoh , et al. · 2024

Objectives To assess diagnostic mycology capacity and available fungal diagnostic services of microbiology laboratories in eight tertiary hospitals in Nigeria and one in Ghana. Methods On-site audits were performed in the microbiology labo…

Resolving the CD4-testing crisis to help end AIDS-related deaths Open

Omar Syarif, Rita Oladele, Tinne Gils, Radha Rajasingham, Jonathan Falconer , et al. · 2024

Features and global impact of invasive fungal infections caused by Pneumocystis jirovecii: A systematic review to inform the World Health Organization fungal priority pathogens list Open

Brendan McMullan, Hannah Yejin Kim, Ana Alastruey‐Izquierdo, Evelina Tacconelli, Aiken Dao , et al. · 2024

This systematic review evaluates the current global impact of invasive infections caused by Pneumocystis jirovecii (principally pneumonia: PJP), and was carried out to inform the World Health Organization Fungal Priority Pathogens List. Pu…

Eumycetoma causative agents: A systematic review to inform the World Health Organization priority list of fungal pathogens Open

Julia Clark, Hannah Yejin Kim, Wendy W. J. van de Sande, Brendan McMullan, Paul E. Verweij , et al. · 2024

The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal priority pathogens list. This systematic review aimed to evaluate the epidemiology and impact of eumycetoma. PubM…

Candida albicans—A systematic review to inform the World Health Organization Fungal Priority Pathogens List Open

Sarika Parambath, Aiken Dao, Hannah Yejin Kim, Shukry Zawahir, Ana Alastruey‐Izquierdo , et al. · 2024

Candida albicans is a common fungal pathogen and amongst the leading causes of invasive candidiasis globally. This systematic review examines the characteristics and global impact of invasive infections caused by C. albicans. We searched o…

Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens Open

Tina Marinelli, Hannah Yejin Kim, Catriona Halliday, Katherine Garnham, Olivia Bupha‐Intr , et al. · 2024

Recognizing the growing global burden of fungal infections, the World Health Organization established a process to develop a priority list of fungal pathogens (FPPL). In this systematic review, we aimed to evaluate the epidemiology and imp…

Histoplasmosis: A systematic review to inform the World Health Organization of a fungal priority pathogens list Open

Aiken Dao, Hannah Yejin Kim, Catriona Halliday, Rita Oladele, Volker Rickerts , et al. · 2024

Histoplasmosis, a significant mycosis primarily prevalent in Africa, North and South America, with emerging reports globally, poses notable health challenges, particularly in immunocompromised individuals such as people living with HIV/AID…

Prevalence of Chronic Pulmonary Aspergillosis in Two (2) Tuberculosis Treatment Clinics in Lagos, Nigeria: A Prospective Longitudinal Study Open

Adeyinka A. Davies, Abiola Omobonike Adekoya, Oluwaseyi Jessy Balogun, Iriagbonse I. Osaigbovo, Augustina Nwosu , et al. · 2024

Background Chronic pulmonary aspergillosis (CPA) is an underrecognized but common complication of pulmonary tuberculosis. In Nigeria, a tuberculosis-endemic country, there is currently no provision to monitor the development of CPA in pati…

Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM Open

Christina C. Chang, Thomas S. Harrison, Tihana Bicanic, Methee Chayakulkeeree, Tania C. Sorrell , et al. · 2024

Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM Open

Christina C. Chang, Thomas S. Harrison, Tihana Bicanic, Methee Chayakulkeeree, Tania C. Sorrell , et al. · 2024

Fungal contamination of the water distribution system of a tertiary hospital water supply system in a resource-limited setting Open

Kolapo Solomon Olawale, Rita Oladele, Rebecca F. Peters, Bassey E. Ekeng, Folasade Ogunsola · 2024

Background: Fungal contamination of hospital water distribution systems has been implicated in outbreaks of healthcare-associated infections. Objectives: To evaluate the prevalence of fungi in the water distribution system of a tertiary ho…

Epidemiology, Clinical Features and Antifungal Resistance Profile of Candida auris in Africa: Systematic Review Open

Isidore W. Yerbanga, S Diallo, Toussaint Rouamba, Delwendé Florence Ouédraogo, Katrien Lagrou , et al. · 2024

International audience

The Nairobi Declaration 2023: A commitment to address deadly yet neglected fungal diseases in Africa Open

Iriagbonse I. Osaigbovo, Nelesh P. Govender, Andrew Jordan, Felix Bongomin, David B. Meya , et al. · 2023

On May 30th and 31st, 2023, delegates representing various African subregions, together with global representatives from the International Society of Human and Animal Mycology (ISHAM), the European Confederation of Medical Mycology (ECMM),…

Candida auris: A Systematic Review of a Globally Emerging Fungal Pathogen in Africa Open

Iriagbonse I. Osaigbovo, Bassey E. Ekeng, Adeyinka A. Davies, Ejime Ebeigbe, Felix Bongomin , et al. · 2023

Candida auris is a World Health Organization critical priority fungal pathogen. We conducted a systematic review to describe its epidemiology in Africa. PubMed and Google scholar databases were searched between January 2009 and September 2…

Recent Advances and Future Perspectives in Mitigating Invasive Antifungal-Resistant Pathogen Aspergillus fumigatus in Africa Open

Conrad Chibunna Achilonu, Adeyinka A. Davies, Okezie Obasi Kanu, Colin Noel, Rita Oladele · 2023

Purpose of Review Azole resistance in Aspergillus fumigatus is an emerging public health issue with global distribution and has been linked to use in agricultural and horticultural settings. In 2022, the World Health Organization (WHO) cre…

Fungal diseases in Africa: Closing the gaps in diagnosis and treatment through implementation research and advocacy Open

Felix Bongomin, Bassey E. Ekeng, Richard Kwizera, Jon Salmanton‐García, Winnie Kibone , et al. · 2023

HIV and fungal priority pathogens Open

Hatim Sati, Ana Alastruey‐Izquierdo, John R. Perfect, Nelesh P. Govender, Thomas S. Harrison , et al. · 2023

In vitro activity of ceftazidime-avibactam against clinical isolates of Enterobacterales and Pseudomonas aeruginosa from sub-Saharan Africa: ATLAS Global Surveillance Program 2017–2021 Open

Mark G. Wise, James A. Karlowsky, Meredith Hackel, Mohamed Amine Harti, Bontle M.E. Ntshole , et al. · 2023

Reference in vitro antimicrobial susceptibility testing demonstrated that most recent Enterobacterales (96%) and P. aeruginosa (89%) clinical isolates from four sub-Saharan African countries were ceftazidime-avibactam susceptible.

Cryptococcal antigenemia in a Nigerian child with advanced HIV disease: a case report Open

Bassey E. Ekeng, Grace I. Nwankwo, Olufunke Adedokun, Glory Ekpo Bassey, Christian Ide , et al. · 2023

Cryptococcal infection in Nigeria’s advanced HIV disease (AHD) population is not uncommon but is sparsely reported in children. The dearth of data on cryptococcal disease in our paediatric population suggests it is an uncommon clinical ent…

Universal use of face mask for the prevention of the spread of COVID-19 in community settings in a South-western State of Nigeria: willingness and barriers Open

Folasade Ogunsola, Chioma Ejekam, Mobolanle Balogun, Igwilo Ugonna, Oluwakemi Ololade Odukoya , et al. · 2023

Rapid Diagnostic Test Value and Implementation in Antimicrobial Stewardship Across Low-to-Middle and High-Income Countries: A Mixed-Methods Review Open

Luke Moore, María Virginia Villegas, Eric Wenzler, Timothy M. Rawson, Rita Oladele , et al. · 2023

Despite technological advancements in infectious disease rapid diagnostic tests (RDTs) and use to direct therapy at the per-patient level, RDT utilisation in antimicrobial stewardship programmes (ASPs) is variable across low-to-middle inco…

Cryptococcus laurentii fungaemia in a Tertiary Hospital in Nigeria: Case reports Open

Adeyinka A. Davies, Chioma Osuagwu, Victoria A. Aikhomu, Rita Oladele · 2023

The non-neoformans Cryptococci are increasingly causing opportunistic infections in both immunocompetent and immunocompromised individuals worldwide. Non. neoformans Cryptococci are skin and mucous membrane colonizers as well as environmen…

Presence of Burkholderia pseudomallei in Soil, Nigeria, 2019 Open

Jelmer Savelkoel, Rita Oladele, Chiedozie Kingsley Ojide, Rebecca F. Peters, Daan W. Notermans , et al. · 2023

Melioidosis, caused by the soil-dwelling bacterium Burkholderia pseudomallei, is predicted to be endemic in Nigeria but is only occasionally reported. This report documents the systematic identification of the presence of B. pseudomallei a…

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