Rita Tewari
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View article: A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis
A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis Open
Meiosis is a conserved yet evolutionarily varied process underpinning sexual reproduction in eukaryotes. In the malaria parasite Plasmodium , meiosis is unconventional: it occurs immediately after fertilisation (post-zygotic) and must be c…
View article: A divergent <i>Plasmodium</i> NEK4 acts as a key regulator driving the early events of meiosis
A divergent <i>Plasmodium</i> NEK4 acts as a key regulator driving the early events of meiosis Open
Meiosis is a conserved yet evolutionarily varied process underpinning sexual reproduction in eukaryotes. In the malaria parasite Plasmodium , meiosis is unconventional: it occurs immediately after fertilisation (post-zygotic) and must be c…
View article: Apicortin defines the Plasmodium apical conoid body during transmission but is dispensable for the parasite life cycle
Apicortin defines the Plasmodium apical conoid body during transmission but is dispensable for the parasite life cycle Open
Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical polar rings, which are essential for parasite motility, host cell invasion, and r…
View article: Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…
View article: <i>Plasmodium</i> ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
<i>Plasmodium</i> ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei Open
Mitosis in eukaryotes involves reorganisation of the nuclear envelope (NE) and microtubule-organising centres (MTOCs). During male gametogenesis in Plasmodium , the causative agent of malaria, mitosis is exceptionally rapid and highly dive…
View article: Author response: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei
Author response: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei Open
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium Open
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly diver…
View article: Author response: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
Author response: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium Open
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei Open
Mitosis in eukaryotes involves reorganisation of the nuclear envelope (NE) and microtubule-organising centres (MTOCs). During male gametogenesis in Plasmodium , the causative agent of malaria, mitosis is exceptionally rapid and highly dive…
View article: Divergent <i>Plasmodium</i> kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Divergent <i>Plasmodium</i> kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis Open
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut are initiated by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by t…
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium Open
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly diver…
View article: Divergent<i>Plasmodium</i>kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Divergent<i>Plasmodium</i>kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis Open
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut is governed by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by thr…
View article: Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation Open
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp., the causative agent of malaria is a dive…
View article: The molecular mechanisms driving <i>Plasmodium</i> cell division
The molecular mechanisms driving <i>Plasmodium</i> cell division Open
Malaria, a vector borne disease, is a major global health and socioeconomic problem caused by the apicomplexan protozoan parasite Plasmodium. The parasite alternates between mosquito vector and vertebrate host, with meiosis in the mosquito…
View article: <i>Plasmodium</i> NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
<i>Plasmodium</i> NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation Open
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp , the causative agent of malaria is a dive…
View article: Atypical flagella assembly and haploid genome coiling during male gamete formation in Plasmodium
Atypical flagella assembly and haploid genome coiling during male gamete formation in Plasmodium Open
Gametogenesis in Plasmodium spp. occurs within the Anopheles mosquito and is essential for sexual reproduction / differentiation and onwards transmission to mammalian hosts. To better understand the 3D organisation of male gametogenesis, w…
View article: Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages Open
View article: Meiosis in Plasmodium: how does it work?
Meiosis in Plasmodium: how does it work? Open
View article: Atypical flagella assembly and haploid genome coiling during male gamete formation in<i>Plasmodium</i>
Atypical flagella assembly and haploid genome coiling during male gamete formation in<i>Plasmodium</i> Open
Plasmodium spp. sexual reproduction occurs within the Anopheles mosquito and is essential for gametogenesis and onwards transmission to mammalian hosts. Upon activation, the male P. berghei gametocyte undergoes three rounds of inter-nuclea…
View article: Author Correction: Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission
Author Correction: Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission Open
View article: Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages
Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages Open
Mechanisms of cell division are remarkably diverse, suggesting the underlying molecular networks among eukaryotes differ extensively. The Aurora family of kinases orchestrates the process of chromosome segregation and cytokinesis during ce…
View article: <i>Plasmodium</i>ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages
<i>Plasmodium</i>ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages Open
Mechanisms of cell division are remarkably diverse, suggesting the underlying molecular networks among eukaryotes differ extensively. The Aurora family of kinases orchestrates the process of chromosome segregation and cytokinesis during ce…
View article: Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission
Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission Open
View article: Rita Tewari: malaria parasite cell division
Rita Tewari: malaria parasite cell division Open
Rita Tewari is a Professor of Parasite Cell Biology at The University of Nottingham, Faculty of Medicine and Health Sciences. We asked her about her recent paper published in Life Science Alliance (LSA) and her experience in science thus f…
View article: Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle
Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle Open
Kinesins are microtubule (MT)-based motors important in cell division, motility, polarity, and intracellular transport in many eukaryotes. However, they are poorly studied in the divergent eukaryotic pathogens Plasmodium spp., the causativ…
View article: Division and Transmission: Malaria Parasite Development in the Mosquito
Division and Transmission: Malaria Parasite Development in the Mosquito Open
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for parasite development, transmission, and survival. Most resear…
View article: <i>Plasmodium</i> SAS4: basal body component of male cell which is dispensable for parasite transmission
<i>Plasmodium</i> SAS4: basal body component of male cell which is dispensable for parasite transmission Open
The centriole/basal body (CBB) is an evolutionarily conserved organelle acting as a microtubule organising centre (MTOC) to nucleate cilia, flagella, and the centrosome. SAS4/CPAP is a conserved component associated with BB biogenesis in m…
View article: Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission
Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission Open
Kinesins are a superfamily of molecular motors that undertake ATP-dependent microtubule-based movement or regulate microtubule dynamics. Plasmodium species, which cause malaria and kill hundreds of thousands annually, encode 8-9 kinesins i…
View article: Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition
Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition Open