Ritobrata Ghose
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View article: Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects
Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects Open
The physical tissue microenvironment regulates cell state and behaviour. How mechanical confinement rewires the subcellular localisation of organelles and affects cellular metabolism is largely unknown. In this study, proteomics analysis r…
View article: Nuclear localization of MTHFD2 is required for correct mitosis progression
Nuclear localization of MTHFD2 is required for correct mitosis progression Open
View article: Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity
Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity Open
View article: Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2
Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2 Open
SUMMARY Metastasis is responsible for nearly 90% of all cancer-related deaths. Despite global efforts to prevent aggressive tumours, cancers such as pancreatic ductal adenocarcinoma (PDAC) are poorly diagnosed in the primary stage, resulti…
View article: A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability
A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability Open
View article: A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans
A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans Open
Developmental patterning in Caenorhabditis elegans is known to proceed in a highly stereotypical manner, which raises the question of how developmental robustness is achieved despite the inevitable stochastic noise. We focus here on a popu…
View article: From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation
From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation Open
The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a vaccine, as well as to contribute to mass test…
View article: GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA
GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA Open
The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff fibrotic matrix, and…
View article: Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number
Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number Open
Biological systems are subject to inherent stochasticity. Nevertheless, development is remarkably robust, ensuring the consistency of key phenotypic traits such as correct cell numbers in a certain tissue. It is currently unclear which gen…