Ritsuko Watanabe
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View article: Time-lapse imaging of cells in spatially fractionated X-ray fields using a mini beam as an alternative to accelerator-based sub-millimeter beams
Time-lapse imaging of cells in spatially fractionated X-ray fields using a mini beam as an alternative to accelerator-based sub-millimeter beams Open
Due to the limited number of accelerator-based X-ray facilities worldwide that provide beams with an adjustable size, their application for radiobiological research purposes has been restricted. Thus, the development of alternative methods…
View article: Luminal progenitor and mature cells are more susceptible than basal cells to radiation-induced DNA double-strand breaks in rat mammary tissue
Luminal progenitor and mature cells are more susceptible than basal cells to radiation-induced DNA double-strand breaks in rat mammary tissue Open
Ionizing radiation promotes mammary carcinogenesis. Induction of DNA double-strand breaks (DSBs) is the initial event after radiation exposure, which can potentially lead to carcinogenesis, but the dynamics of DSB induction and repair are …
View article: Based on the experience of combined mammography and ultrasound screening
Based on the experience of combined mammography and ultrasound screening Open
View article: Current status of mammography and breast ultrasound combined screening at our facility
Current status of mammography and breast ultrasound combined screening at our facility Open
現在の対策型乳がん検診の基本はマンモグラフィである。しかし，マンモグラフィは若年者を中心とした高濃度乳房において病変の感度が不十分であると報告されており，さらには高濃度乳房以外でもマンモグラフィだけでは指摘できない乳がんも存在する。「乳がん検診における超音波検査の有効性を検証するための比較試験（J―START）」がLANCET にも掲載されているが，死亡率低減効果が証明されていないため，現時点では対策型としての超音波検診は推奨されていない。 栃木県は，早くから超音波検診を導…
View article: No Intercellular Regulation of the Cell Cycle among Human Cervical Carcinoma HeLa Cells Expressing Fluorescent Ubiquitination-Based Cell-Cycle Indicators in Modulated Radiation Fields
No Intercellular Regulation of the Cell Cycle among Human Cervical Carcinoma HeLa Cells Expressing Fluorescent Ubiquitination-Based Cell-Cycle Indicators in Modulated Radiation Fields Open
The non-targeted effects of radiation have been known to induce significant alternations in cell survival. Although the effects might govern the progression of tumor sites following advanced radiotherapy, the impacts on the intercellular c…
View article: <i>Spirulina platensis</i> and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model
<i>Spirulina platensis</i> and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model Open
Non-alcoholic steatohepatitis is the chronic liver disease leading to cirrhosis and cancer and its prevalence is increasing. Some agents are under clinical trials for non-alcoholic steatohepatitis treatment. We previously reported Spiru…
View article: Spatially Fractionated Microbeam Analysis of Tissue-sparing Effect for Spermatogenesis
Spatially Fractionated Microbeam Analysis of Tissue-sparing Effect for Spermatogenesis Open
Spatially fractionated radiation therapy (SFRT) has been based on the delivery of a single high-dose fraction to a large treatment area that has been divided into several smaller fields, reducing the overall toxicity and adverse effects. C…
View article: The Tissue-Sparing Effect of Spatially Fractionated X-rays for Maintaining Spermatogenesis: A Radiobiological Approach for the Preservation of Male Fertility after Radiotherapy
The Tissue-Sparing Effect of Spatially Fractionated X-rays for Maintaining Spermatogenesis: A Radiobiological Approach for the Preservation of Male Fertility after Radiotherapy Open
Radiotherapy can result in temporary or permanent gonadal toxicity in male cancer patients despite the high precision and accuracy of modern radiation treatment techniques. Previous radiobiological studies have shown an effective tissue-sp…
View article: High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation
High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation Open
View article: 16 Computer Simulation Study of Initial Process of Radiation Biological Effect
16 Computer Simulation Study of Initial Process of Radiation Biological Effect Open
放射線による生物影響のメカニズムの解明には，モデルやシミュレーションを用いた研究は重要な役割を持つ。特に，メカニズムに関する仮定や生体の異なるレベルで得られた実験データの間の関係を評価するためにはシミュレーションは有効な手段である。本稿では，DNAと細胞への放射線影響のシミュレーションによる研究の概要について述べる。この中で，DNA損傷生成に関わる物理化学過程の詳細を推定する理論的アプローチと，DNA損傷と細胞応答のダイナミクスを推定する数理モデルも紹介する。
View article: 沖縄のスポーツツーリズムとホスピタリティに関する比較研究 : 「ECOスピリットライド＆ウォークin南城市」と「GREAT EARTH 石垣島ライド」における事例から
沖縄のスポーツツーリズムとホスピタリティに関する比較研究 : 「ECOスピリットライド＆ウォークin南城市」と「GREAT EARTH 石垣島ライド」における事例から Open
As a participatory type of tourism, sports tourism enables sustained economic benefits stemming from tourism since some tourists, if they enjoyed the sporting events, will make another visit in order to participate again. Additionally, we …
View article: Cellular automaton-based model for radiation-induced bystander effects
Cellular automaton-based model for radiation-induced bystander effects Open