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View article: History of Clinical Services, Medical Training, and Research for Spinal Cord Injuries and Disorders in the United States Veterans Health Administration
History of Clinical Services, Medical Training, and Research for Spinal Cord Injuries and Disorders in the United States Veterans Health Administration Open
View article: Viewpoint on Big Data Analytics for Improved Patient Outcomes: Applications of the Veterans Health Administration Spinal Cord Injuries and Disorders Registry (VHA SCIDR) for Precision Medicine (Preprint)
Viewpoint on Big Data Analytics for Improved Patient Outcomes: Applications of the Veterans Health Administration Spinal Cord Injuries and Disorders Registry (VHA SCIDR) for Precision Medicine (Preprint) Open
BACKGROUND Since the 1990s, the Veterans Health Administration (VHA) has maintained a system-wide digital database to provide integrated care for 9 million Veterans across 172 medical centers and 1,138 outpatient clinics in the United Sta…
View article: Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder
Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder Open
Importance Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the …
View article: <i>GLP1R</i> Gene Expression and Kidney Disease Progression
<i>GLP1R</i> Gene Expression and Kidney Disease Progression Open
Importance Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have nephroprotective properties beyond those related to weight loss and glycemic control. Objective To investigate the association of genetically proxied GLP-1RAs with ki…
View article: Genetically predicted lipoprotein(a) associates with coronary artery plaque severity independent of low-density lipoprotein cholesterol
Genetically predicted lipoprotein(a) associates with coronary artery plaque severity independent of low-density lipoprotein cholesterol Open
Aims Elevated lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease, but the mechanisms of risk are debated. Studies have found inconsistent associations between Lp(a) and measurements of atherosclerosis…
View article: Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans
Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans Open
Background Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as risk for Alzheimer’s disease and related dementias (ADRD). Overlapping symptom profiles o…
View article: Type 1 Diabetes Genetic Risk in 109,954 Veterans With Adult-Onset Diabetes: The Million Veteran Program (MVP)
Type 1 Diabetes Genetic Risk in 109,954 Veterans With Adult-Onset Diabetes: The Million Veteran Program (MVP) Open
OBJECTIVE To characterize high type 1 diabetes (T1D) genetic risk in a population where type 2 diabetes (T2D) predominates. RESEARCH DESIGN AND METHODS Characteristics typically associated with T1D were assessed in 109,594 Million Veteran …
View article: Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy Open
The Phenome-Wide Association Study (PheWAS) is increasingly used to broadly screen for potential treatment effects, e.g., IL6R variant as a proxy for IL6R antagonists. This approach offers an opportunity to address the limited power in cli…
View article: Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1
Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1 Open
View article: Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk
Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk Open
Importance Clinical trial data have called into question the efficacy of thiazide diuretics for the prevention of kidney stones. Objective To identify whether there is an association between genetic proxies of thiazide diuretics and the ri…
View article: Overview of Efforts to Increase Women Enrollment in the Veterans Affairs Million Veteran Program
Overview of Efforts to Increase Women Enrollment in the Veterans Affairs Million Veteran Program Open
The MVP Women's Campaign is the first large-scale outreach effort focusing on recruitment of women Veterans into MVP. The combination of print and digital outreach tactics and direct email recruitment resulted in over a fivefold increase i…
View article: Identifying intragenic functional modules of genomic variations associated with cancer phenotypes by learning representation of association networks
Identifying intragenic functional modules of genomic variations associated with cancer phenotypes by learning representation of association networks Open
View article: Data Resource Profile: Self-reported data in the Million Veteran Program: survey development and insights from the first 850 736 participants
Data Resource Profile: Self-reported data in the Million Veteran Program: survey development and insights from the first 850 736 participants Open
View article: <i>APOL1</i> Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program
<i>APOL1</i> Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program Open
In this cohort study of veterans with African ancestry hospitalized with COVID-19 infection, APOL1 kidney risk variants were associated with higher odds of AKI, AKI severity, and death, even among individuals with prior normal kidney funct…