Rachmat Hidayat
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View article: Activated Growth Factor (AGF) as a Superior Biological Therapy for Osteoarthritis: Comparative Efficacy in Modulating Cartilage Degeneration and Inflammation in vivo
Activated Growth Factor (AGF) as a Superior Biological Therapy for Osteoarthritis: Comparative Efficacy in Modulating Cartilage Degeneration and Inflammation in vivo Open
Platelet-derived AGF, as an advanced mode of PRP, effectively regulates the anabolic-catabolic processes in OA cartilage. It achieved this by significantly inhibiting key catabolic enzymes and pro-inflammatory mediators, while concurrently…
View article: Epigenetic Regulation of Sorbitol Dehydrogenase in Diabetic Retinopathy Patients: DNA Methylation, Histone Acetylation and microRNA-320
Epigenetic Regulation of Sorbitol Dehydrogenase in Diabetic Retinopathy Patients: DNA Methylation, Histone Acetylation and microRNA-320 Open
The findings suggest that microRNA-320 plays a crucial role in regulating SDH enzyme activity in patients with type 2 diabetes and DR. The development of microRNA-320-based therapies, such as miRNA mimics or antagomirs, may offer a novel a…
View article: Activated Growth Factor From Platelets as Treatment for Diabetic Retinopathy Through Antioxidant-Oxidative Stress Pathway
Activated Growth Factor From Platelets as Treatment for Diabetic Retinopathy Through Antioxidant-Oxidative Stress Pathway Open
The study shows that AGF, with TGF-β concentrations of 10 ng/mL and 100 ng/mL, can reduce AGEs, p38MAPK, Nf-κβ, ROS, TNF-α, IL-1β, VCAM-1, ICAM-1, and VEGF in diabetic retinopathy rats' retinal tissue, while increasing antioxidant SOD conc…
View article: Activated Growth Factors (AGF), an Advanced Platelet-Rich Plasma (PRP) Modality, as a Novel Biological Treatment for Partial Anterior Cruciate Ligament Tears: A Case Report
Activated Growth Factors (AGF), an Advanced Platelet-Rich Plasma (PRP) Modality, as a Novel Biological Treatment for Partial Anterior Cruciate Ligament Tears: A Case Report Open
Introduction: Partial anterior cruciate ligament (ACL) ruptures present a complex clinical challenge. Traditional treatment options, including conservative management and surgical reconstruction, often yield unpredictable outcomes and exte…
View article: Activated Growth Factor (AGF): An Advanced Modality of Platelet-Rich Plasma as a New Biological Agent for the Treatment of Degenerative and Traumatic Conditions
Activated Growth Factor (AGF): An Advanced Modality of Platelet-Rich Plasma as a New Biological Agent for the Treatment of Degenerative and Traumatic Conditions Open
Platelet-rich plasma (PRP) has emerged as a promising therapeutic modality for various medical applications, particularly in regenerative medicine and wound healing. This is largely attributed to its rich concentration of growth factors (G…
View article: Analysis of Main Facilities Utilization in Lambada Fishery Port, Aceh Besar
Analysis of Main Facilities Utilization in Lambada Fishery Port, Aceh Besar Open
The purpose of this study was to determine the level of utilization of basic facilities at the Lambada Fishing Port, Aceh Besar. This study was located at the Lambada Fishing Port, Aceh Besar. The data taken in this study were secondary da…
View article: Examining Leverage and Sales Growth: Their Influence on Stock Prices of Agricultural Firms on the Indonesia Stock Exchange
Examining Leverage and Sales Growth: Their Influence on Stock Prices of Agricultural Firms on the Indonesia Stock Exchange Open
Information available in the capital market influences investor confidence, which in turn impacts market efficiency. Stock prices are a crucial factor for every investor to consider when investing in shares. Higher stock prices indicate be…
View article: Extract Ethanol of Tempuyung (Sonchus arvensis) Leaves as Anti-Hyperuricemia: In Vitro Studies
Extract Ethanol of Tempuyung (Sonchus arvensis) Leaves as Anti-Hyperuricemia: In Vitro Studies Open
Hyperuricemia is a condition where there is an increase in blood uric acid levels above 7 mg/dL in men and 6 mg/dl in women. One of the enzymes that plays a role in hyperuricemia is xanthine oxidase which can inhibit uric acid synthesis. T…
View article: GENERATION Z PARTICIPATION IN POLITICS AN APPROACH TO CONSUMER BEHAVIOR THEORY
GENERATION Z PARTICIPATION IN POLITICS AN APPROACH TO CONSUMER BEHAVIOR THEORY Open
Research aimed at finding out the causes of Generation Z playing an active role in politics was carried out using a qualitative methodology using phenomology. By using the snowball technique in determining informants, there were eight Gene…
View article: Effectiveness of Mesenchymal Stem Cells in Tissue Regeneration in Ear Injuries: A Meta-Analysis
Effectiveness of Mesenchymal Stem Cells in Tissue Regeneration in Ear Injuries: A Meta-Analysis Open
Introduction: Ear injuries are a common health problem and can cause significant hearing loss. Tissue regeneration in injured ears is still a big challenge. Mesenchymal stem cells (MSCs) have shown potential for tissue regeneration in vari…
View article: Effectiveness of MRI in Detecting and Diagnosing Brain Tumors in Children: A Meta-Analysis
Effectiveness of MRI in Detecting and Diagnosing Brain Tumors in Children: A Meta-Analysis Open
Introduction: Brain tumors are one of the most common types of cancer in children. Accurate and timely diagnosis is essential to determine optimal treatment and improve patient prognosis. Magnetic resonance imaging (MRI) has become one of …
View article: Nilai-nilai Profil Pelajar Pancasila dalam Dongeng Betawi Tempo Doeloe Karya Abdul Chaer
Nilai-nilai Profil Pelajar Pancasila dalam Dongeng Betawi Tempo Doeloe Karya Abdul Chaer Open
Dongeng merupakan salah satu media yang sangat efektif untuk menanamkan nilai-nilai luhur yang berkaitan dengan Profil Pelajar Pancasila. Tujuan penelitian ini untuk mendeskripsikan nilai-nilai Profil Pelajar Pancasila yang terdapat dalam …
View article: The Effect of Activated Growth Factor (AGF) from Platelets on Alpha-SMA Levels in Osteoarthritis: Invivo Study
The Effect of Activated Growth Factor (AGF) from Platelets on Alpha-SMA Levels in Osteoarthritis: Invivo Study Open
Background: The most prevalent joint condition and leading contributor to disability is osteoarthritis (OA), resulting in a significant socio-economic impact. It occurs due to an imbalance of pro-inflammatory and anti-inflammatory mediator…
View article: Parenting Patterns' Impact on the Likelihood of Mental Disorders in Palembang, Indonesia
Parenting Patterns' Impact on the Likelihood of Mental Disorders in Palembang, Indonesia Open
Introduction: Parenting style has a crucial role in shaping a child's physical and mental growth. The objective of this study is to assess the impact of parenting styles on the likelihood of developing mental problems in the urban area of …
View article: The Impact of Gastroesophageal Reflux Disease (GERD) on Pharyngeal Mucosal Changes: A Case-Control Study in Indonesia
The Impact of Gastroesophageal Reflux Disease (GERD) on Pharyngeal Mucosal Changes: A Case-Control Study in Indonesia Open
Introduction: Gastroesophageal reflux disease (GERD) is a prevalent digestive disorder with potential extra-esophageal manifestations, including laryngopharyngeal reflux (LPR). LPR can lead to various pharyngeal mucosal changes, impacting …
View article: A Comparative Study of Intranasal Corticosteroids versus Antihistamines in the Management of Persistent Allergic Rhinitis in Indonesia
A Comparative Study of Intranasal Corticosteroids versus Antihistamines in the Management of Persistent Allergic Rhinitis in Indonesia Open
Introduction: Allergic rhinitis (AR) is a prevalent chronic inflammatory disease in Indonesia. Intranasal corticosteroids (INCS) and antihistamines are commonly prescribed treatments, but their comparative effectiveness in the Indonesian c…
View article: The Impact of Gestational Diabetes on Long-Term Cognitive Function: A Prospective Cohort Study with Neuroimaging Correlates in Bandung, Indonesia
The Impact of Gestational Diabetes on Long-Term Cognitive Function: A Prospective Cohort Study with Neuroimaging Correlates in Bandung, Indonesia Open
Introduction: Gestational diabetes mellitus (GDM) is a growing public health concern with potential long-term consequences for both mother and child. Emerging evidence suggests that GDM may impact maternal cognitive function, but the under…
View article: The Influence of Influencer Marketing in Increasing Brand Awareness and Sales for SMEs
The Influence of Influencer Marketing in Increasing Brand Awareness and Sales for SMEs Open
In the ever-evolving digital era, marketing through social media has become one of the most effective tools to promote products and services. One of the latest marketing trends that is emerging is the use of influencers in marketing strate…
View article: Knowledge, Attitudes, and Practices Regarding Contraception Among Young Women in Urban Indonesia: A Mixed-Methods Approach
Knowledge, Attitudes, and Practices Regarding Contraception Among Young Women in Urban Indonesia: A Mixed-Methods Approach Open
Introduction: Unintended pregnancies and unsafe abortions remain significant public health concerns in Indonesia, particularly among young women in urban areas. This study aimed to explore the knowledge, attitudes, and practices (KAP) rega…
View article: The Role of Pattern Recognition Receptor (PRR) in the Body's Defense System: A Narrative Literature Review
The Role of Pattern Recognition Receptor (PRR) in the Body's Defense System: A Narrative Literature Review Open
Each cell has receptors on the cell surface that specifically bind to solutes (ligands) produced during tissue damage or infection. This review aimed to describe the role of PRR in the human body's defense system. The binding of the ligand…
View article: The Role of Natural Physical, Mechanical, and Biochemical Barriers as Innate Immunity: A Narrative Literature Review
The Role of Natural Physical, Mechanical, and Biochemical Barriers as Innate Immunity: A Narrative Literature Review Open
The specialized epithelial outer layer, including the skin and mucosal surfaces, is relatively resistant to most environmental hazards and resistant to infection by disease-causing microorganisms. This literature review aimed to describe t…
View article: Inflammatory Response Plays a Role in Innate Immunity: A Narrative Literature Review
Inflammatory Response Plays a Role in Innate Immunity: A Narrative Literature Review Open
The inflammatory response is the rapid initiation and interplay of humoral (dissolved in the blood) and cellular systems designed to limit the degree of tissue damage, destroy infectious microorganisms, initiate an adaptive immune response…
View article: Mechanisms of Cellular Adaptation and Change: A Narrative Literature Review
Mechanisms of Cellular Adaptation and Change: A Narrative Literature Review Open
Injury to cells and the surrounding environment, called the extracellular matrix, triggers injury to tissues and organs. Although a normal cell is limited by narrow boundaries of structure and function, it is capable of adapting to biologi…
View article: Counseling on the Potency of Platelet Growth Factor in the Management of Ankle Sprain Trauma in Orthopedic Polyclinic Patients at YK Madira Hospital, Palembang, Indonesia
Counseling on the Potency of Platelet Growth Factor in the Management of Ankle Sprain Trauma in Orthopedic Polyclinic Patients at YK Madira Hospital, Palembang, Indonesia Open
Growth factors are not only capable of triggering cell and tissue repair but also act as anti-inflammatory molecules, capable of inhibiting inflammatory processes triggered by trauma. However, currently, patients with ankle sprains are sti…
View article: Counseling on the Potential of Platelet Growth Factor as a Biological Agent to Overcome Osteoarthritis Disorders at Ar-Rasyid Hospital Palembang Indonesia
Counseling on the Potential of Platelet Growth Factor as a Biological Agent to Overcome Osteoarthritis Disorders at Ar-Rasyid Hospital Palembang Indonesia Open
Growth factor is a cytokine that plays a role in triggering a series of inhibition of inflammatory processes and triggers repair of joint cartilage which acts as a shock absorber. However, the current phenomenon shows that patients are sti…
View article: Genetic Predisposition to Cardiac Conduction Defects in a Multi-Ethnic Population: A Case-Control Study in Palembang, Indonesia
Genetic Predisposition to Cardiac Conduction Defects in a Multi-Ethnic Population: A Case-Control Study in Palembang, Indonesia Open
Introduction: Cardiac conduction defects (CCDs) represent a significant global health burden, contributing to morbidity and mortality. While environmental and lifestyle factors are recognized contributors, genetic predisposition plays a cr…
View article: Living with Tinnitus: A Qualitative Exploration of Indonesian Patients' Coping Strategies and Support Needs
Living with Tinnitus: A Qualitative Exploration of Indonesian Patients' Coping Strategies and Support Needs Open
Introduction: Tinnitus, the perception of sound without an external source, affects many people globally. Its causes are varied and often unclear, and it can significantly impact the quality of life, causing distress, sleep problems, and c…
View article: Beyond Amyloid: Investigating the Role of Tau Oligomers in Alzheimer's Disease Progression in Medan, Indonesia
Beyond Amyloid: Investigating the Role of Tau Oligomers in Alzheimer's Disease Progression in Medan, Indonesia Open
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and memory impairment. While amyloid plaques have been a central focus of AD research, increasing evidence suggests that tau oligomer…
View article: Social Determinants of Health and Their Influence on Preterm Birth in Rural Indonesian Communities
Social Determinants of Health and Their Influence on Preterm Birth in Rural Indonesian Communities Open
Introduction: Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major contributor to neonatal mortality and morbidity globally, with a disproportionate burden in low-resource settings like rural Indonesia. …
View article: Multidimensional Analysis of Risk Factors for Stunting in Rural South Sumatra, Indonesia: A Community-Based Study
Multidimensional Analysis of Risk Factors for Stunting in Rural South Sumatra, Indonesia: A Community-Based Study Open
Introduction: Stunting remains a pressing public health concern in Indonesia, particularly in rural areas. This study aimed to comprehensively analyze the multidimensional risk factors associated with stunting in rural South Sumatra, consi…