Rizliya Visvanathan
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View article: Dexamethasone enhances intestinal glucose absorption and TMPRSS2 expression with implications for hyperglycaemia and infection risk
Dexamethasone enhances intestinal glucose absorption and TMPRSS2 expression with implications for hyperglycaemia and infection risk Open
Long-term corticosteroid use, including dexamethasone, is associated with an increased risk of type 2 diabetes, leading to enhanced hepatic gluconeogenesis and peripheral insulin resistance. This study reveals that dexamethasone additional…
View article: In vitro antioxidant potential of eleven medicinal herbs in Sri Lanka: Correlation with phenols and flavonoids
In vitro antioxidant potential of eleven medicinal herbs in Sri Lanka: Correlation with phenols and flavonoids Open
Antioxidants play a crucial role in preventing and treating non-communicable diseases (NCDs) by scavenging free radicals. Medicinal herbs, used for centuries in traditional healthcare systems, have been gaining attention recently due to th…
View article: Impact of Glucose, Inflammation and Phytochemicals on ACE2, TMPRSS2 and Glucose Transporter Gene Expression in Human Intestinal Cells
Impact of Glucose, Inflammation and Phytochemicals on ACE2, TMPRSS2 and Glucose Transporter Gene Expression in Human Intestinal Cells Open
Inflammation is associated with the pathophysiology of type 2 diabetes and COVID-19. Phytochemicals have the potential to modulate inflammation, expression of SARS-CoV-2 viral entry receptors (angiotensin-converting enzyme 2 (ACE2) and tra…
View article: Inhibition of Human Salivary and Pancreatic α-Amylase by Resveratrol Oligomers
Inhibition of Human Salivary and Pancreatic α-Amylase by Resveratrol Oligomers Open
A key strategy to mitigate postprandial hyperglycemia involves inhibiting α-amylases, which commence the starch digestion process in the gut. This study examined the inhibitory effects of resveratrol and stilbenoid tetramers, vaticanol B, …
View article: Structure-function relationships in (poly)phenol-enzyme binding: Direct inhibition of human salivary and pancreatic α-amylases
Structure-function relationships in (poly)phenol-enzyme binding: Direct inhibition of human salivary and pancreatic α-amylases Open
(Poly)phenols inhibit α-amylase by directly binding to the enzyme and/or by forming starch-polyphenol complexes. Conventional methods using starch as the substrate measure inhibition from both mechanisms, whereas the use of shorter oligosa…
View article: Dietary phytochemicals as regulators of gut inflammation in the context of type 2 diabetes
Dietary phytochemicals as regulators of gut inflammation in the context of type 2 diabetes Open
Numerous disorders, including type 2 diabetes and even COVID-19, are linked to poor gut health and inflammation (1,2) . In addition to impacting food digestion and absorption, gut inflammation worsens diabetes outcomes by causing gut micro…
View article: Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies
Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies Open
Evidence from in vitro, animal, and human studies links citrus fruit consumption with several health‐promoting effects. However, many in vitro studies disregard bioavailability data, a key factor determining responses in humans. Citrus (po…
View article: Barber et al Nature Protocols Source Data - Figure 6.xlsx
Barber et al Nature Protocols Source Data - Figure 6.xlsx Open
Figure 6: Acarbose inhibition of enzyme activity. Inhibition by acarbose is demonstrated for human α-amylase using maltoheptaose (Mal-7), and sucrase, maltase and isomaltase activities, using sucrose, maltose and isomaltose, respectively. …
View article: Barber et al Nature Protocols Source Data - Figure 5.xlsx
Barber et al Nature Protocols Source Data - Figure 5.xlsx Open
Figure 5: Increasing product formation with increased enzyme or substrate concentrations. The different sheets show results from using maltoheptaose in the α-amylase assay or sucrose, maltose and isomaltose as the substrate in each α-gluco…
View article: Barber et al Nature Protocols Source Data - Figure 4.xlsx
Barber et al Nature Protocols Source Data - Figure 4.xlsx Open
Figure 4: Data for representative chromatograms showing efficient separation of the expected substrates and products of maltooligosaccharides in the α-amylase assay and low molecular weight sugars in the α-glucosidase assay, by HPAE-PAD io…
View article: Citrus polyphenols and risk of type 2 diabetes: Evidence from mechanistic studies
Citrus polyphenols and risk of type 2 diabetes: Evidence from mechanistic studies Open
Citrus fruits are a rich source of (poly)phenols, a group of dietary bioactive compounds that protect against developing type 2 diabetes. Our review critically evaluates how experimental in vitro and animal models have elucidated some of t…
View article: Effect of citrus fruit and juice consumption on risk of developing type 2 diabetes: Evidence on polyphenols from epidemiological and intervention studies
Effect of citrus fruit and juice consumption on risk of developing type 2 diabetes: Evidence on polyphenols from epidemiological and intervention studies Open
Citrus fruits are commonly consumed worldwide in both fresh and processed forms, especially as juices. While fruit consumption is perceived as beneficial for long-term health, the effects of fruit juices are more controversial, linked to h…
View article: Comparison of fermentation properties in raw and boiled legumes after simulated digestion
Comparison of fermentation properties in raw and boiled legumes after simulated digestion Open
This study compared the fermentation properties of selected raw and boiled legumes after simulated digestion. Raw and boiled; mung bean, two cowpea cultivars (Waruni and Dhawala), horse gram, and chickpea were subjected to simulated digest…
View article: Maltoheptaoside hydrolysis with chromatographic detection and starch hydrolysis with reducing sugar analysis: Comparison of assays allows assessment of the roles of direct α-amylase inhibition and starch complexation
Maltoheptaoside hydrolysis with chromatographic detection and starch hydrolysis with reducing sugar analysis: Comparison of assays allows assessment of the roles of direct α-amylase inhibition and starch complexation Open
The aim was to determine inhibition of human α-amylase activity by (poly)phenols using maltoheptaoside as substrate with direct chromatographic product quantification, compared to hydrolysis of amylose and amylopectin estimated using 3,5-d…
View article: Sesbania grandiflora L. Poir leaves: A dietary supplement to alleviate type 2 diabetes through metabolic enzymes inhibition
Sesbania grandiflora L. Poir leaves: A dietary supplement to alleviate type 2 diabetes through metabolic enzymes inhibition Open
Sesbania grandiflora L. Poir is an edible medicinal plant widely distributed in Asian countries. One of its folk medicinal uses is the alleviation or treatment of Type 2 Diabetes mellitus (T2DM). A number of animal studies confirmed its us…
View article: Boiled, sprouted, and raw cowpea‐incorporated diets modulate high‐fat diet‐induced hypercholesterolemia in rats
Boiled, sprouted, and raw cowpea‐incorporated diets modulate high‐fat diet‐induced hypercholesterolemia in rats Open
This study was carried out to investigate the effect of processed (boiled and sprouted) cowpea‐incorporated experimental diets on serum cholesterol and serum antioxidant capacity in high‐fat diet ( HFD )‐fed Wistar rats. Seven weeks old ma…
View article: Banana Blossom (<i>Musa acuminate</i>Colla) Incorporated Experimental Diets Modulate Serum Cholesterol and Serum Glucose Level in Wistar Rats Fed with Cholesterol
Banana Blossom (<i>Musa acuminate</i>Colla) Incorporated Experimental Diets Modulate Serum Cholesterol and Serum Glucose Level in Wistar Rats Fed with Cholesterol Open
Hypocholesterolaemic and hypoglycaemic effect of banana blossom were studied in high-cholesterol fed rats. Experimental groups were fed for 4 weeks, with casein as the basal diet (CN), in comparison with two diets containing 0.5% cholester…
View article: Comparative Analysis of Nutritional and Bioactive Properties of Aerial Parts of Snake Gourd (<i>Trichosanthes cucumerina</i>Linn.)
Comparative Analysis of Nutritional and Bioactive Properties of Aerial Parts of Snake Gourd (<i>Trichosanthes cucumerina</i>Linn.) Open
The present investigation was carried out to determine the nutritional and functional properties of T. cucumerina . Water extracts of freeze dried flowers, fruits, and leaves of T . cucumerina were evaluated for their total phenolic conten…