Rob C. Aalberse
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View article: <scp>EAACI</scp>Molecular Allergology User's Guide 2.0
<span>EAACI</span>Molecular Allergology User's Guide 2.0 Open
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response…
View article: Editorial Board
Editorial Board Open
View article: A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles
A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles Open
Background Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies in allergy. Methods Immunoglobulin E (IgE) sensitization profiles w…
View article: Editorial Board
Editorial Board Open
View article: Carbohydrate epitopes currently recognized as targets for IgE antibodies
Carbohydrate epitopes currently recognized as targets for IgE antibodies Open
Until recently, glycan epitopes have not been documented by the WHO/IUIS Allergen Nomenclature Sub‐Committee. This was in part due to scarce or incomplete information on these oligosaccharides, but also due to the widely held opinion that …
View article: Does maternal IgG protect infants from allergen-specific IgE sensitization?
Does maternal IgG protect infants from allergen-specific IgE sensitization? Open
View article: Unique patterns of glycosylation in immunoglobulin subclass G4‐related disease and primary sclerosing cholangitis
Unique patterns of glycosylation in immunoglobulin subclass G4‐related disease and primary sclerosing cholangitis Open
Background and Aim Immunoglobulin subclass G4‐related disease (IgG4‐RD) is characterized by an abundance of IgG4 antibodies in the serum and tissue. Glycosylation status of antibodies can impact on immune effector functions and disease pat…
View article: OTU-020 Altered FC and FAB glycosylation status in patients with IGG4-related sclerosing cholangitis and autoimmune pancreatitis
OTU-020 Altered FC and FAB glycosylation status in patients with IGG4-related sclerosing cholangitis and autoimmune pancreatitis Open
Introduction IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition characterised by an abundance of IgG4+ antibodies in the serum and tissue of involved organs. IgG glycosylation plays an important role in ma…
View article: Increases in IgE, Eosinophils, and Mast Cells Can be Used in Diagnosis and to Predict Relapse of IgG4-Related Disease
Increases in IgE, Eosinophils, and Mast Cells Can be Used in Diagnosis and to Predict Relapse of IgG4-Related Disease Open
View article: Room temperature structure of human IgG4-Fc from crystals analysed in situ
Room temperature structure of human IgG4-Fc from crystals analysed in situ Open
View article: A new framework for the interpretation of IgE sensitization tests
A new framework for the interpretation of IgE sensitization tests Open
IgE sensitization tests, such as skin prick testing and serum-specific IgE, have been used to diagnose IgE-mediated clinical allergy for many years. Their prime drawback is that they detect sensitization which is only loosely related to cl…
View article: The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response
The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response Open
View article: EAACI Molecular Allergology User's Guide
EAACI Molecular Allergology User's Guide Open
The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ ( CRD ). The European Academy of All…
View article: Table of Contents
Table of Contents Open
View article: Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease
Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease Open
This is the first study to show enhanced levels of polyclonal IgG4 to multiple antigens in IgG4-RD. This supports that elevated IgG4 levels reflect an aberrant immunological regulation of the overall IgG4 response, but does not exclude tha…