Robert Cooper
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View article: The Management and Clinical Outcomes of Pregnancy in a Female With Glycogen Storage Disease Type <scp>IIIA</scp> Caused by Rare Variant
The Management and Clinical Outcomes of Pregnancy in a Female With Glycogen Storage Disease Type <span>IIIA</span> Caused by Rare Variant Open
Glycogen storage disease type III (GSD III) is an inborn error of carbohydrate metabolism with an autosomal recessive inheritance pattern. Phenotypically, patients can manifest a broad clinical spectrum. Most patients affected with GSD III…
View article: Efficacy of aficamten in patients with obstructive hypertrophic cardiomyopathy and mild symptoms: results from the SEQUOIA-HCM trial
Efficacy of aficamten in patients with obstructive hypertrophic cardiomyopathy and mild symptoms: results from the SEQUOIA-HCM trial Open
Background and Aims Patients with obstructive hypertrophic cardiomyopathy (oHCM) treated with aficamten in SEQUOIA-HCM (NCT05186818) demonstrated marked improvement in symptoms and functional capacity. This analysis explores whether oHCM a…
View article: Preferred and Actual Location of Death in Adolescents and Young Adults With Cancer
Preferred and Actual Location of Death in Adolescents and Young Adults With Cancer Open
Importance Adolescent and young adult (AYA) patients with advanced cancer often die in hospital settings. Data characterizing the degree to which this pattern of care is concordant with patient goals are sparse. Objective To evaluate the e…
View article: Tale of three services: early UK experience with mavacamten treatment for hypertrophic cardiomyopathy with left ventricular outflow tract obstruction
Tale of three services: early UK experience with mavacamten treatment for hypertrophic cardiomyopathy with left ventricular outflow tract obstruction Open
Background Hypertrophic cardiomyopathy (HCM) is characterised by abnormal thickening of ventricular myocardium. Left ventricular outflow tract (LVOT) obstruction occurs in up to 70% of patients, causing progressive symptoms, heart failure …
View article: Evolution in Documented Goals of Care at End of Life for Adolescents and Younger Adults With Cancer
Evolution in Documented Goals of Care at End of Life for Adolescents and Younger Adults With Cancer Open
Importance Little is known about the nature of change in goals of care (GOC) over time among adolescents and younger adult (AYA) patients aged 12 to 39 years with cancer near the end of life. Understanding how GOC evolve may guide clinicia…
View article: Considerations for drug trials in hypertrophic cardiomyopathy
Considerations for drug trials in hypertrophic cardiomyopathy Open
Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden car…
View article: Multi‐modal video search by examples—A video quality impact analysis
Multi‐modal video search by examples—A video quality impact analysis Open
As the proliferation of video content continues, and many video archives lack suitable metadata, therefore, video retrieval, particularly through example‐based search, has become increasingly crucial. Existing metadata often fails to meet …
View article: Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA‐HCM
Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA‐HCM Open
Background Aficamten, a novel cardiac myosin inhibitor, reversibly reduces cardiac hypercontractility in obstructive hypertrophic cardiomyopathy. We present a prespecified analysis of the pharmacokinetics, pharmacodynamics, and safety of a…
View article: Canadian Cardiovascular Society Clinical Practice Update on Contemporary Management of the Patient With Hypertrophic Cardiomyopathy
Canadian Cardiovascular Society Clinical Practice Update on Contemporary Management of the Patient With Hypertrophic Cardiomyopathy Open
Numerous guidelines on the diagnosis and management of hypertrophic cardiomyopathy (HCM) have been published, by learned societies, over the past decade. Although helpful they are often long and less adapted to nonexperts. This writing pan…
View article: Sex differences of 12 lead electrocardiographic findings of the rugby football league athlete
Sex differences of 12 lead electrocardiographic findings of the rugby football league athlete Open
Cardiac electrical adaptations occur within athlete populations. Sex-related variations in the normal athlete electrocardiogram (ECG) have been observed, with males exhibiting increased QRS and PR intervals, while females have demonstrated…
View article: Bi-ventricular structure and function in resistance trained athletes using anabolic androgenic steroids as determined by three-dimensional echocardiography
Bi-ventricular structure and function in resistance trained athletes using anabolic androgenic steroids as determined by three-dimensional echocardiography Open
Background Anabolic androgenic steroids (AAS) are frequently used by resistance trained (RT) individuals and their use has been shown to have a negative impact on left ventricular (LV) structure and function albeit with limited evidence pe…
View article: 10 Mavacamten therapy in the management of symptomatic obstructive hypertrophic cardiomyopathy: a single UK centre experience
10 Mavacamten therapy in the management of symptomatic obstructive hypertrophic cardiomyopathy: a single UK centre experience Open
Introduction Hypertrophic cardiomyopathy (HCM) is a genetic disorder of cardiac myocytes leading to myocardial hypercontractility and left ventricular hypertrophy. Disease-causing genetic alterations result in enhanced calcium sensitivity …
View article: Use of cancer-directed therapy at the end of life among adolescents and young adults
Use of cancer-directed therapy at the end of life among adolescents and young adults Open
Background Adolescents and young adults frequently receive chemotherapy near death. We know less about the use of targeted agents and immunotherapy or trends over time. Methods We conducted a retrospective cohort study of 1836 adolescents …
View article: Development and Validation of the COVID-19 Hospitalized Patient Deterioration Index
Development and Validation of the COVID-19 Hospitalized Patient Deterioration Index Open
COVID-HDI is a parsimonious, well-calibrated, and accurate model that may support clinical decision-making around discharge and escalation of care.
View article: The impact of image and performance enhancing drugs on atrial structure and function in resistance trained individuals
The impact of image and performance enhancing drugs on atrial structure and function in resistance trained individuals Open
Background Image and performance enhancing drugs (IPEDs) are commonly used in resistance trained (RT) individuals and negatively impact left ventricular (LV) structure and function. Few studies have investigated the impact of IPEDs on atri…
View article: Need an endomyocardial biopsy? Call your electrophysiology team
Need an endomyocardial biopsy? Call your electrophysiology team Open
Introduction With significant advances in targeted chemotherapeutic options for soft tissue tumours, obtaining a tissue diagnosis is more important than ever. Primary and secondary cardiac tumours are rare [1] and endomyocardial biopsy of …
View article: Quality of End-of-Life Care Among Adolescents and Young Adults With Cancer
Quality of End-of-Life Care Among Adolescents and Young Adults With Cancer Open
Adolescents, young adults with cancer receive limited psychosocial and spiritual support near death.
View article: The athlete’s heart: insights from echocardiography
The athlete’s heart: insights from echocardiography Open
The manifestations of the athlete’s heart can create diagnostic challenges during an echocardiographic assessment. The classifications of the morphological and functional changes induced by sport participation are often beyond ‘normal limi…
View article: Comparison of echocardiographic methods for calculating left ventricular mass in elite rugby football league athletes and the impact on chamber geometry
Comparison of echocardiographic methods for calculating left ventricular mass in elite rugby football league athletes and the impact on chamber geometry Open
Background Recommendations for the echocardiographic assessment of left ventricular (LV) mass in the athlete suggest the use of the linear method using a two-tiered classification system (2TC). The aims of this study were to compare the li…
View article: British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of cardiac amyloidosis
British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of cardiac amyloidosis Open
These guidelines form an update of the BSE guideline protocol for the assessment of restrictive cardiomyopathy (Knight et al. in Echo Res Prac, 2013). Since the original recommendations were conceived in 2013, there has been an exponential…
View article: Discussions About Goals of Care and Advance Care Planning Among Adolescents and Young Adults With Cancer Approaching the End of Life
Discussions About Goals of Care and Advance Care Planning Among Adolescents and Young Adults With Cancer Approaching the End of Life Open
AYAs with cancer who have early goals-of-care discussions receive less-intensive care at life’s end.
View article: Concentric and Eccentric Remodelling of the Left Ventricle and Its Association to Function in the Male Athletes Heart: An Exploratory Study
Concentric and Eccentric Remodelling of the Left Ventricle and Its Association to Function in the Male Athletes Heart: An Exploratory Study Open
Aims: To compare (1) conventional left ventricular (LV) functional parameters, (2) LV peak strain and strain rate and (3) LV temporal strain and strain rate curves in age, ethnicity and sport-matched athletes with concentric, eccentric and…
View article: The role of histological subtypes in the survival of patients diagnosed with cutaneous or mucosal melanoma in the United States of America
The role of histological subtypes in the survival of patients diagnosed with cutaneous or mucosal melanoma in the United States of America Open
Background Literature presents limited information on histological subtypes and their association with other factors influencing the survival of melanoma patients. To explore the risk of death due to melanoma associated with histological s…