Rob J. Vandebriel
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View article: Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells
Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells Open
View article: MACRAMÉ – Advanced characterisation methodologies to assess and predict the health and environmental risks of advanced materials
MACRAMÉ – Advanced characterisation methodologies to assess and predict the health and environmental risks of advanced materials Open
View article: Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers
Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers Open
Respiratory sensitization is a complex immunological process eventually leading to hypersensitivity following re-exposure to the chemical. A frequent consequence is occupational asthma, which may occur after long latency periods. Although …
View article: Evaluating the conduct and reporting of the T-cell dependent antibody response in the Extended One-Generation Reproductive Toxicity study provided under the EU REACH regulation
Evaluating the conduct and reporting of the T-cell dependent antibody response in the Extended One-Generation Reproductive Toxicity study provided under the EU REACH regulation Open
The European Union (EU) Chemicals Strategy for Sustainability regards chemicals that affect the immune system among the most harmful ones. The Extended One-Generation Reproductive Toxicity study (EOGRTS; Organisation for Economic Co-Operat…
View article: Nano(bio)Materials Do Not Affect Macrophage Phenotype—A Study Conducted by the REFINE Project
Nano(bio)Materials Do Not Affect Macrophage Phenotype—A Study Conducted by the REFINE Project Open
Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses, particul…
View article: Nano(bio)materials Do Not Affect Macrophage Phenotype – A Study Conducted by the REFINE Project
Nano(bio)materials Do Not Affect Macrophage Phenotype – A Study Conducted by the REFINE Project Open
Macrophages are well known for the involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses; particular…
View article: New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project
New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project Open
As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of …
View article: Variability of in vivo potency assays of whole-cell pertussis, inactivated polio, and meningococcal B vaccines
Variability of in vivo potency assays of whole-cell pertussis, inactivated polio, and meningococcal B vaccines Open
For the batch release of vaccines, potency release assays are required. Non-animal in vitro tests have numerous advantages and are preferred; however, several vaccines are still released using in vivo assays. Their major drawback is the in…
View article: Transferability and reproducibility of exposed air-liquid interface co-culture lung models
Transferability and reproducibility of exposed air-liquid interface co-culture lung models Open
View article: Application of KU812 cells for assessing complement activation related effects by nano(bio)materials
Application of KU812 cells for assessing complement activation related effects by nano(bio)materials Open
Immunocompatibility issues related to nano(bio)materials, particularly liposomal formulations, involving activation of the complement system have been relatively well described however, they highlight the importance of preclinical evaluati…
View article: 97 Transferability and Reproducibility of Exposed Air-Liquid Interface co-Culture Lung Models
97 Transferability and Reproducibility of Exposed Air-Liquid Interface co-Culture Lung Models Open
The establishment of reliable and robust in vitro models for hazard assessment, moving away from animal testing, requires evaluation of model transferability and reproducibility. Lung models that can be exposed via the air, by means of an …
View article: Physiologically‐Based Kinetic Modeling of Intravenously Administered Gold (Au) Nanoparticles
Physiologically‐Based Kinetic Modeling of Intravenously Administered Gold (Au) Nanoparticles Open
Physiologically‐based kinetic (PBK) modeling is a valuable tool to understand the kinetics of nanoparticles (NPs) in vivo. However, estimating PBK parameters remains challenging and commonly requires animal studies. To develop predictive m…
View article: Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)
Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS) Open
Background Per- and polyfluoroalkyl substances (PFAS) are of public health concern, because of their ubiquitous and extremely persistent occurrence, and depending on their structure, their bio-accumulative, mobile and toxic properties. Hum…
View article: Internal relative potency factors based on immunotoxicity for the risk assessment of mixtures of per- and polyfluoroalkyl substances (PFAS) in human biomonitoring
Internal relative potency factors based on immunotoxicity for the risk assessment of mixtures of per- and polyfluoroalkyl substances (PFAS) in human biomonitoring Open
Relative potency factors (RPFs) for per- and polyfluoroalkyl substances (PFAS) have previously been derived based on liver effects in rodents for the purpose of performing mixture risk assessment with primary input from biomonitoring studi…
View article: Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response
Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response Open
Usage of injectable dermal fillers applied for aesthetic purposes has extensively increased over the years. As such, the number of related adverse reactions has increased, including patients showing severe complications such as product mig…
View article: An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials
An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials Open
View article: Development of a cell line-based in vitro assay for assessment of Diphtheria, Tetanus and acellular Pertussis (DTaP)-induced inflammasome activation
Development of a cell line-based in vitro assay for assessment of Diphtheria, Tetanus and acellular Pertussis (DTaP)-induced inflammasome activation Open
Safety and potency assessment for batch release testing of established vaccines still relies partly on animal tests. An important avenue to move to batch release without animal testing is the consistency approach. This approach is based on…
View article: An inter-laboratory comparison of an NLRP3 inflammasome activation assay and dendritic cell maturation assay using a nanostructured lipid carrier and a polymeric nanomedicine, as exemplars
An inter-laboratory comparison of an NLRP3 inflammasome activation assay and dendritic cell maturation assay using a nanostructured lipid carrier and a polymeric nanomedicine, as exemplars Open
View article: Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison
Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison Open
View article: Evaluation of Adverse Effects of Resorbable Hyaluronic Acid Fillers: Determination of Macrophage Responses
Evaluation of Adverse Effects of Resorbable Hyaluronic Acid Fillers: Determination of Macrophage Responses Open
Resorbable tissue fillers for aesthetic purposes can induce severe complications including product migration, late swelling, and inflammatory reactions. The relation between product characteristics and adverse effects is not well understoo…
View article: Pathways Related to NLRP3 Inflammasome Activation Induced by Gold Nanorods
Pathways Related to NLRP3 Inflammasome Activation Induced by Gold Nanorods Open
The widespread and increasing use of engineered nanomaterials (ENM) increases the risk of human exposure, generating concern that ENM may provoke adverse health effects. In this respect, their physicochemical characteristics are critical. …
View article: Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances
Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances Open
The use of nanobiomaterials (NBMs) is becoming increasingly popular in the field of medicine. To improve the understanding on the biodistribution of NBMs, the present study aimed to implement and parametrize a physiologically based pharmac…
View article: A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS
A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS Open
The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic procedures to addr…
View article: Corrigendum to “Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines” [Vaccine 39(18) (2021) 2506–2516]
Corrigendum to “Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines” [Vaccine 39(18) (2021) 2506–2516] Open
View article: A comparative biodistribution study of polymeric and lipid-based nanoparticles
A comparative biodistribution study of polymeric and lipid-based nanoparticles Open
Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical properties …
View article: A Decision Support System for Preclinical Assessment of Nanomaterials in Medical Products: The REFINE DSS
A Decision Support System for Preclinical Assessment of Nanomaterials in Medical Products: The REFINE DSS Open
The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic procedures to addr…
View article: Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions
Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions Open
Background: Ensuring consistency of tetanus neurotoxin (TeNT) production by Clostridium tetani could help to ensure consistent product quality in tetanus vaccine manufacturing, ultimately contributing to reduced animal testing. The aim of …
View article: Internal Relative Potency Factors Based on Immunotoxicity for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring
Internal Relative Potency Factors Based on Immunotoxicity for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring Open
View article: Overcoming scientific barriers in the transition from<i>in vivo</i>to non-animal batch testing of human and veterinary vaccines
Overcoming scientific barriers in the transition from<i>in vivo</i>to non-animal batch testing of human and veterinary vaccines Open
For safety testing, many in vitro alternatives are already available or at an advanced level of development. For potency testing, in vitro alternatives largely comprise immunochemical methods that assess several, but not all …
View article: Applicability of organ-on-chip systems in toxicology and pharmacology
Applicability of organ-on-chip systems in toxicology and pharmacology Open
Organ-on-chip (OoC) systems are microfabricated cell culture devices designed to model functional units of human organs by harboring an in vitro generated organ surrogate. In the present study, we reviewed issues and opportunities r…