Rob Mariman
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View article: Resurgence of <i>Bordetella pertussis</i> in the Netherlands in 2023-2024 reveals novel mutation in T3SS translocator gene <i>bopD</i>
Resurgence of <i>Bordetella pertussis</i> in the Netherlands in 2023-2024 reveals novel mutation in T3SS translocator gene <i>bopD</i> Open
Background Despite decades of vaccination whooping cough has not been eliminated and epidemics are known to occur every 3 to 5 years. As a consequence of the COVID-19 pandemic and associated non-pharmaceutical interventions, pertussis has …
View article: Digital PCR Linkage Analysis Resolves <i>Streptococcus pneumoniae</i> Signature from Commensal Interference in Saliva Samples: Identifying Wolves among Sheep in Wolf’s Clothing
Digital PCR Linkage Analysis Resolves <i>Streptococcus pneumoniae</i> Signature from Commensal Interference in Saliva Samples: Identifying Wolves among Sheep in Wolf’s Clothing Open
Background Serotyping of Streptococcus pneumoniae (pneumococcus) is essential for evaluating the effects of conjugate polysaccharide vaccines on asymptomatic colonization (carriage) of vaccine-targeted capsular variants (serotypes). Howeve…
View article: Streptococcus pneumoniae serotype 38 emerges as one of the dominant serotypes causing invasive pneumococcal disease in Germany and Poland, but not in the Netherlands
Streptococcus pneumoniae serotype 38 emerges as one of the dominant serotypes causing invasive pneumococcal disease in Germany and Poland, but not in the Netherlands Open
The recent surge in non-vaccine serotype 38 among IPD cases in Germany and Poland cannot be explained by changes in antimicrobial resistance or other genetic changes. Our study underscores the importance of international collaboration in m…
View article: Impact of age on pneumococcal colonization of the nasopharynx and oral cavity: an ecological perspective
Impact of age on pneumococcal colonization of the nasopharynx and oral cavity: an ecological perspective Open
Pneumococcal carriage studies have suggested that pneumococcal colonization in adults is largely limited to the oral cavity and oropharynx. In this study, we used total abundance-based β-diversity (dissimilarity) and β-diversity components…
View article: Impact of age-related differences of the nasopharynx and oral cavity on pneumococcal colonisation: An ecological perspective
Impact of age-related differences of the nasopharynx and oral cavity on pneumococcal colonisation: An ecological perspective Open
Pneumococcal carriage studies have suggested that pneumococcal colonization in adults is largely limited to the oral cavity and oropharynx. In this study we used total abundance-based β-diversity (dissimilarity) and β-diversity components …
View article: Meningococcal carriage in children and young adults: a cross-sectional and longitudinal study, Iceland, 2019 to 2021
Meningococcal carriage in children and young adults: a cross-sectional and longitudinal study, Iceland, 2019 to 2021 Open
Background Neisseria meningitidis is a commensal bacterium which can cause invasive disease. Colonisation studies are important to guide vaccination strategies. Aim The study’s aim was to determine the prevalence of meningococcal colonisat…
View article: A spitting image: molecular diagnostics applied to saliva enhance detection of Streptococcus pneumoniae and pneumococcal serotype carriage
A spitting image: molecular diagnostics applied to saliva enhance detection of Streptococcus pneumoniae and pneumococcal serotype carriage Open
Background Despite strong historical records on the accuracy of saliva testing, oral fluids are considered poorly suited for pneumococcal carriage detection. We evaluated an approach for carriage surveillance and vaccine studies that incre…
View article: Longitudinal dynamics of<i>Streptococcus pneumoniae</i>carriage and SARS-CoV-2 infection in households with children
Longitudinal dynamics of<i>Streptococcus pneumoniae</i>carriage and SARS-CoV-2 infection in households with children Open
Background To characterize interferences between Streptococcus pneumoniae and SARS-CoV-2 we investigated the longitudinal patterns of viral infection and pneumococcal carriage in households infected with SARS-CoV-2. Methods SARS-CoV-2 and …
View article: Meningococcal vaccination in adolescents and adults induces bactericidal activity against hyperinvasive complement-resistant meningococcal isolates
Meningococcal vaccination in adolescents and adults induces bactericidal activity against hyperinvasive complement-resistant meningococcal isolates Open
Background Complement-mediated killing is critical in the defense against meningococci. During a recent outbreak of invasive meningococcal serogroup W disease (IMD-W) in the Netherlands, the predominant isolates belonged to clonal complex …
View article: It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Streptococcus pneumoniae Detection and Pneumococcal Serogroup/Serotype Determination in Carriage
It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Streptococcus pneumoniae Detection and Pneumococcal Serogroup/Serotype Determination in Carriage Open
Background The specificity of molecular methods for the detection of Streptococcus pneumoniae carriage is under debate. We propose a procedure for carriage surveillance and vaccine impact studies that increases the accuracy of molecular de…
View article: High Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Household Transmission Rates Detected by Dense Saliva Sampling
High Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Household Transmission Rates Detected by Dense Saliva Sampling Open
Background Understanding the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission is important for adequate infection control measures in this ongoing pandemic. Methods Households were enrolled up…
View article: Detection of Neisseria meningitidis in saliva and oropharyngeal samples from college students
Detection of Neisseria meningitidis in saliva and oropharyngeal samples from college students Open
Carriage of Neisseria meningitidis is an accepted endpoint in monitoring meningococcal vaccines effects. We have assessed N. meningitidis and vaccine-type genogroup carriage prevalence in college students at the time of MenACWY vaccine int…
View article: It Takes Two to Tango: Combining Conventional Culture with Molecular Diagnostics Enhances Accuracy of <i>Streptococcus pneumoniae</i> Detection and Pneumococcal Serogroup/Serotype determination in Carriage
It Takes Two to Tango: Combining Conventional Culture with Molecular Diagnostics Enhances Accuracy of <i>Streptococcus pneumoniae</i> Detection and Pneumococcal Serogroup/Serotype determination in Carriage Open
Background The specificity of molecular methods for the detection of Streptococcus pneumoniae carriage is under debate. We propose a procedure that increases the accuracy of molecular detection of live pneumococci in polymicrobial respirat…
View article: Increase in invasive disease caused by Haemophilus influenzae b, the Netherlands, 2020 to 2021
Increase in invasive disease caused by Haemophilus influenzae b, the Netherlands, 2020 to 2021 Open
The incidence of most respiratory-transmitted diseases decreased during the COVID-19 pandemic as a result of containment measures. In contrast, in the Netherlands we noted an increase in invasive disease caused by Haemophilus influenzae b …
View article: Detection of<i>Neisseria meningitidis</i>in Saliva and Oropharyngeal Samples from College Students
Detection of<i>Neisseria meningitidis</i>in Saliva and Oropharyngeal Samples from College Students Open
Objectives Since conjugated polysaccharide vaccines reduce carriage of vaccine-type Neisseria meningitidis strains, meningococcal carriage is an accepted endpoint in monitoring vaccine effects. We have assessed vaccine-type genogroup carri…
View article: Regulatory KIR<sup>+</sup>RA<sup>+</sup> T cells accumulate with age and are highly activated during viral respiratory disease
Regulatory KIR<sup>+</sup>RA<sup>+</sup> T cells accumulate with age and are highly activated during viral respiratory disease Open
Severe respiratory viral infectious diseases such as influenza and COVID‐19 especially affect the older population. This is partly ascribed to diminished CD8 + T‐cell responses a result of aging. The phenotypical diversity of the CD8 + T‐c…
View article: High SARS-CoV-2 Household Transmission Rates Detected by Dense Saliva Sampling
High SARS-CoV-2 Household Transmission Rates Detected by Dense Saliva Sampling Open
View article: Naturally circulating pertactin-deficient <i>Bordetella pertussis</i> strains induce distinct gene expression and inflammatory signatures in human dendritic cells
Naturally circulating pertactin-deficient <i>Bordetella pertussis</i> strains induce distinct gene expression and inflammatory signatures in human dendritic cells Open
Respiratory infections caused by Bordetella pertussis are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating B. pertussis
View article: Influenza-like Illness Exacerbates Pneumococcal Carriage in Older Adults
Influenza-like Illness Exacerbates Pneumococcal Carriage in Older Adults Open
Background In older adults, pneumococcal disease is strongly associated with respiratory viral infections, but the impact of viruses on Streptococcus pneumoniae carriage prevalence and load remains poorly understood. Here, we investigated …
View article: Airborne particulate matter from goat farm increases acute allergic airway responses in mice
Airborne particulate matter from goat farm increases acute allergic airway responses in mice Open
Background: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthm…
View article: Immunological effects of shift work in healthcare workers
Immunological effects of shift work in healthcare workers Open
View article: Phylodynamics of pertussis in the vaccine era: transition to re-emergence
Phylodynamics of pertussis in the vaccine era: transition to re-emergence Open
This manuscript has been withdrawn owing to an author dispute.
View article: Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages
Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages Open
Pertussis is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis. Humans are the only known natural reservoir of B. pertussis. In mice, macrophages and NK cells have a key role in confining …
View article: Microbiome composition of airborne particulate matter from livestock farms and their effect on innate immune receptors and cells
Microbiome composition of airborne particulate matter from livestock farms and their effect on innate immune receptors and cells Open
View article: <i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor
<i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor Open
Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging …
View article: Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance
Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance Open
Aging poses an increased risk of severe infection by respiratory syncytial virus (RSV). The many different biological pathways comprising the response to infection in lungs that are influenced by aging are complex and remain to be defined …
View article: IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes Open
View article: <i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor
<i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor Open
Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some co…
View article: Fine-mapping inflammatory bowel disease loci to single-variant resolution
Fine-mapping inflammatory bowel disease loci to single-variant resolution Open
View article: Association mapping of inflammatory bowel disease loci to single variant resolution
Association mapping of inflammatory bowel disease loci to single variant resolution Open
Summary Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disorder that affects millions worldwide. Genome-wide association studies (GWAS) have identified 200 IBD-associated loci, but few have been conclusively re…