Rob Roudijk
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View article: Body surface potential mapping of ventricular depolarization and repolarization in phospholamban and plakophilin-2 cardiomyopathy
Body surface potential mapping of ventricular depolarization and repolarization in phospholamban and plakophilin-2 cardiomyopathy Open
View article: Body surface potential mapping detects early disease onset in <i>plakophilin-2</i>-pathogenic variant carriers
Body surface potential mapping detects early disease onset in <i>plakophilin-2</i>-pathogenic variant carriers Open
Aims Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive inherited cardiac disease. Early detection of disease and risk stratification remain challenging due to heterogeneous phenotypic expression. The standard configur…
View article: Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia
Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia Open
Aims Little is known about patients with right bundle branch block (RBBB)-ventricular tachycardia (VT) and arrhythmogenic cardiomyopathy (ACM). Our aims were: (i) to describe electrocardiogram (ECG) characteristics of sinus rhythm (SR) and…
View article: Incorporating structural abnormalities in equivalent dipole layer based ECG simulations
Incorporating structural abnormalities in equivalent dipole layer based ECG simulations Open
Introduction: Electrical activity of the myocardium is recorded with the 12-lead ECG. ECG simulations can improve our understanding of the relation between abnormal ventricular activation in diseased myocardium and body surface potentials …
View article: Modeling the His-Purkinje Effect in Non-invasive Estimation of Endocardial and Epicardial Ventricular Activation
Modeling the His-Purkinje Effect in Non-invasive Estimation of Endocardial and Epicardial Ventricular Activation Open
Inverse electrocardiography ( i ECG) estimates epi- and endocardial electrical activity from body surface potentials maps (BSPM). In individuals at risk for cardiomyopathy, non-invasive estimation of normal ventricular activation may provi…
View article: The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy
The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy Open
Aims In arrhythmogenic cardiomyopathy (ACM), sustained ventricular tachycardia (VT) typically displays a left bundle branch block (LBBB) morphology while a right bundle branch block (RBBB) morphology is rare. The present study assesses the…
View article: Risk stratification and subclinical phenotyping of dilated and/or arrhythmogenic cardiomyopathy mutation-positive relatives: CVON eDETECT consortium
Risk stratification and subclinical phenotyping of dilated and/or arrhythmogenic cardiomyopathy mutation-positive relatives: CVON eDETECT consortium Open
In relatives of index patients with dilated cardiomyopathy and arrhythmogenic cardiomyopathy, early detection of disease onset is essential to prevent sudden cardiac death and facilitate early treatment of heart failure. However, the optim…
View article: Comparison of two equivalent dipole layer based inverse electrocardiography techniques for the non-invasive estimation of His-Purkinje mediated ventricular activation
Comparison of two equivalent dipole layer based inverse electrocardiography techniques for the non-invasive estimation of His-Purkinje mediated ventricular activation Open
Non-invasive estimation of the cardiac activation sequence through inverse electrocardiography (iECG) based on the equivalent double layer becomes increasingly difficult for multiple activation waves through the myocardium.Earlier studies …
View article: Disease-Specific Electrocardiographic Lead Positioning for Early Detection of Arrhythmogenic Right Ventricular Cardiomyopathy
Disease-Specific Electrocardiographic Lead Positioning for Early Detection of Arrhythmogenic Right Ventricular Cardiomyopathy Open
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by replacement of cardiomyocytes by fibrofatty tissue which can lead to ventricular arrhythmias, heart failure or sudden cardiac death. Genetic defects in desmosomal p…
View article: The electro-anatomical pathway for normal and abnormal ECGs in COVID patients
The electro-anatomical pathway for normal and abnormal ECGs in COVID patients Open
Patients with COVID-19 frequently have non-typical ECG changes in the QRS and T-wave morphology.The novel CineECG uses using the mean temporal spatial isochrones (mTSI) to relate the activation and recovery pathway to the cardiac anatomy.T…
View article: Big Data and Artificial Intelligence: Opportunities and Threats in Electrophysiology
Big Data and Artificial Intelligence: Opportunities and Threats in Electrophysiology Open
The combination of big data and artificial intelligence (AI) is having an increasing impact on the field of electrophysiology. Algorithms are created to improve the automated diagnosis of clinical ECGs or ambulatory rhythm devices. Further…
View article: Sustained ventricular tachycardia of left, right or both bundle branch block morphology in patients with Arrhythmogenic Cardiomyopathy
Sustained ventricular tachycardia of left, right or both bundle branch block morphology in patients with Arrhythmogenic Cardiomyopathy Open
Aims In arrhythmogenic cardiomyopathy (ACM) sustained monomorphic ventricular tachycardia (VT) typically displays left bundle branch block (LBBB) morphology. Sustained VT with right bundle branch block (RBBB) morphology is very rare despit…
View article: Arrhythmogenic Right Ventricular Cardiomyopathy in a Pediatric Patient
Arrhythmogenic Right Ventricular Cardiomyopathy in a Pediatric Patient Open
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is rarely diagnosed in childhood. We describe the case of a 9-year-old girl with genetically confirmed ARVC who presented with syncope, ventricular arrhythmia, and biventricular myocar…
View article: Quantitative Approach to Fragmented QRS in Arrhythmogenic Cardiomyopathy: From Disease towards Asymptomatic Carriers of Pathogenic Variants
Quantitative Approach to Fragmented QRS in Arrhythmogenic Cardiomyopathy: From Disease towards Asymptomatic Carriers of Pathogenic Variants Open
Fragmented QRS complexes (fQRS) are common in patients with arrhythmogenic cardiomyopathy (ACM). A new method of fQRS quantification may aid early disease detection in pathogenic variant carriers and assessment of prognosis in patients wit…
View article: Novel use of repolarization parameters in electrocardiographic imaging to uncover arrhythmogenic substrate
Novel use of repolarization parameters in electrocardiographic imaging to uncover arrhythmogenic substrate Open
Measuring novel repolarization parameters in reconstructed electrograms acquired with ECGI is feasible, can be done in a fully automated manner and may provide additional information on underlying arrhythmogenic substrate for risk stratifi…
View article: Diagnosing arrhythmogenic right ventricular cardiomyopathy by 2010 Task Force Criteria: clinical performance and simplified practical implementation
Diagnosing arrhythmogenic right ventricular cardiomyopathy by 2010 Task Force Criteria: clinical performance and simplified practical implementation Open
Aims Arrhythmogenic right ventricular cardiomyopathy (ARVC) is diagnosed by a complex set of clinical tests as per 2010 Task Force Criteria (TFC). Avoiding misdiagnosis is crucial to prevent sudden cardiac death as well as unnecessary impl…
View article: Optimizing Cardiac Source Model Accuracy by Incorporating Endocardial Electro-anatomical Structures
Optimizing Cardiac Source Model Accuracy by Incorporating Endocardial Electro-anatomical Structures Open
Non-invasive estimation of the cardiac activation sequence by solving the inverse problem of electrocardiography based on the equivalent double layer is appropriate for premature ventricular beats.However, the method has to be improved to …
View article: Mean Temporal Spatial Isochrones as Marker for Activation Delay in Patients with Arrhythmogenic Cardiomyopathy
Mean Temporal Spatial Isochrones as Marker for Activation Delay in Patients with Arrhythmogenic Cardiomyopathy Open
Patients with arrhythmogenic cardiomyopathy (ACM) often present with ventricular arrhythmias due to local activation delay. Early detection of activation delay could aid in preventing sudden cardiac death. The aim of this feasibility study…