Rob Sayers
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View article: Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study
Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study Open
WIfI clinical stage is strongly associated with major amputation at 1-year in patients with CLTI. Given its lack of association with QoL, WIfI stages may not reflect the full severity of symptoms experienced by patients.
View article: Patient and Family Perspectives on Cascade Screening for Thoracic Aortic Disease: A Mixed-Methods Evaluation
Patient and Family Perspectives on Cascade Screening for Thoracic Aortic Disease: A Mixed-Methods Evaluation Open
BackgroundCascade screening enables effective secondary prevention and early treatment for Thoracic Aortic Disease (TAD) and increases survival. Despite guideline recommendations, the uptake of screening remains low. This study investigate…
View article: Association of cognitive impairment and peripheral artery disease (PAD): A systematic review
Association of cognitive impairment and peripheral artery disease (PAD): A systematic review Open
This systematic review aimed to describe the association between peripheral artery disease (PAD) and cognitive impairment or dementia. We included studies reporting on the association between PAD (defined by ankle–brachial index ⩽ 0.9) and…
View article: Regional variation in non-traumatic major lower limb amputation in England: observational study of linked primary and secondary care data
Regional variation in non-traumatic major lower limb amputation in England: observational study of linked primary and secondary care data Open
Background Peripheral artery disease and diabetes are the main primary risk factors for non-traumatic major lower limb amputation. Regional variation in incidence of major lower limb amputation has yet to be fully described in terms of the…
View article: Core outcome sets in symptomatic peripheral artery disease, COS-PAD: Study protocol for developing core outcome sets in symptomatic PAD utilising systematic reviews, interviews, and delphi consensus.
Core outcome sets in symptomatic peripheral artery disease, COS-PAD: Study protocol for developing core outcome sets in symptomatic PAD utilising systematic reviews, interviews, and delphi consensus. Open
COMET registrations: 1590 and 2650.
View article: Reported outcomes in studies of intermittent claudication - first step toward a core outcome set: systematic review
Reported outcomes in studies of intermittent claudication - first step toward a core outcome set: systematic review Open
Introduction This review aimed to compile an exhaustive list of all outcome measures and identify different characteristics of the outcomes reported in studies of intermittent claudication as the first step in developing a core outcome set…
View article: Streamlined Clinical Management Pathways May Reduce Major Amputations in Patients with Chronic Limb Threatening Ischaemia: A Prospective Cohort Study with Historical Controls
Streamlined Clinical Management Pathways May Reduce Major Amputations in Patients with Chronic Limb Threatening Ischaemia: A Prospective Cohort Study with Historical Controls Open
An encouraging reduction in major amputation incidence was observed after improvements to CLTI management pathways, but residual confounding is likely. The generalisability of these results is uncertain.
View article: Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems
Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems Open
Ian Roberts and colleagues call for greater use of this inexpensive generic drug that can improve surgical outcomes, avoid unnecessary blood transfusion, and conserve blood stocks
View article: New Horizons in Peripheral Artery Disease
New Horizons in Peripheral Artery Disease Open
Peripheral artery disease (PAD) is the lower limb manifestation of systemic atherosclerotic disease. PAD may initially present with symptoms of intermittent claudication, whilst chronic limb-threatening ischaemia (CLTI), the end stage of P…
View article: Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth
Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth Open
Background There is a clinical need for treatments that can slow or prevent the growth of an abdominal aortic aneurysm, not only to reduce the need for surgery, but to provide a means to treat those who cannot undergo surgery. Methods Anal…
View article: Peripheral artery disease (PAD) in primary care—educational experiences for PAD primary care in England—a mixed-method study
Peripheral artery disease (PAD) in primary care—educational experiences for PAD primary care in England—a mixed-method study Open
Background Peripheral artery disease (PAD), the pathophysiologic narrowing of arterial blood vessels of the lower leg due to atherosclerosis, is a highly prevalent disease, with sharp increases in prevalence with age. Primary care is ideal…
View article: Tranexamic acid for safer surgery: the time is now
Tranexamic acid for safer surgery: the time is now Open
Tranexamic acid reduces surgical bleeding. Consistent with previous research, the POISE-3 (Peri-Operative Ischemic Evaluation-3) trial found that tranexamic acid reduces major bleeding by 25% and with a low probability of any increase in t…
View article: Medical Education in a Post COVID-19 era – remote teaching methods for cardiovascular knowledge and skills
Medical Education in a Post COVID-19 era – remote teaching methods for cardiovascular knowledge and skills Open
This article was migrated. The article was marked as recommended. Introduction As traditional clinical teaching faces major obstacles during the COVID-19 pandemic, medical educators look toward remote teaching methods to provide solutions …
View article: Leg ischaemia management collaboration (LIMb): study protocol for a prospective cohort study at a single UK centre
Leg ischaemia management collaboration (LIMb): study protocol for a prospective cohort study at a single UK centre Open
Introduction Severe limb ischaemia (SLI) is the end stage of peripheral arterial occlusive disease where the viability of the limb is threatened. Around 25% of patients with SLI will ultimately require a major lower limb amputation, which …