Robby M. Weimer
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View article: Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade
Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade Open
View article: Cellular-resolution OCT reveals layer-specific retinal mosaics and ganglion cell degeneration in mouse retina in vivo
Cellular-resolution OCT reveals layer-specific retinal mosaics and ganglion cell degeneration in mouse retina in vivo Open
Cellular-resolution retinal imaging in preclinical mouse models is limited by optical aberrations and speckle noise that prevent visualization of individual cells. We developed a wavefront sensorless adaptive optics optical coherence tomog…
View article: Imaging Synaptic Density in Aging and Alzheimer Disease with [<sup>18</sup>F]SynVesT-1
Imaging Synaptic Density in Aging and Alzheimer Disease with [<sup>18</sup>F]SynVesT-1 Open
Synaptic density imaging with PET is a relatively new approach to monitoring synaptic injury in neurodegenerative diseases. However, there are remaining technical and clinical questions, including questions on reference region selection an…
View article: Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism
Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism Open
INTRODUCTION Triggering receptor expressed on myeloid cells 2 (TREM2) agonists are being clinically evaluated as disease‐modifying therapeutics for Alzheimer's disease. Clinically translatable pharmacodynamic (PD) biomarkers are needed to …
View article: Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer’s Disease and Multiple Sclerosis
Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer’s Disease and Multiple Sclerosis Open
Human genetics and preclinical studies have identified key contributions of TREM2 to several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically. Here, we characterize the activities of three TREM2 agonist ant…
View article: Evaluation of partial volume correction and analysis of longitudinal [18F]GTP1 tau PET imaging in Alzheimer's disease using linear mixed-effects models
Evaluation of partial volume correction and analysis of longitudinal [18F]GTP1 tau PET imaging in Alzheimer's disease using linear mixed-effects models Open
Purpose We evaluated the impact of partial volume correction (PVC) methods on the quantification of longitudinal [ 18 F]GTP1 tau positron-emission tomography (PET) in Alzheimer's disease and the suitability of describing the tau pathology …
View article: Preliminary results investigating synaptic density across the Alzheimer’s Disease continuum
Preliminary results investigating synaptic density across the Alzheimer’s Disease continuum Open
Background Progressive loss of synapses occurs throughout the Alzheimer’s Disease (AD) continuum and is closely associated with cognitive impairment. Here, we present pilot data investigating variation in synaptic density across aging and …
View article: CenTauR: Toward a universal scale and masks for standardizing tau imaging studies
CenTauR: Toward a universal scale and masks for standardizing tau imaging studies Open
INTRODUCTION Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied th…
View article: CenTauR<sub>z</sub>: A standardized quantification of tau PET scans
CenTauR<sub>z</sub>: A standardized quantification of tau PET scans Open
Background Over the past decade, several PET tracers were developed to visualise and quantify tau pathology in vivo. However, all these tracers have distinct off‐target binding, different dynamic ranges and likely different levels of non‐s…
View article: CenTauR: Towards a Universal Scale and Masks for Standardizing Tau Imaging Studies
CenTauR: Towards a Universal Scale and Masks for Standardizing Tau Imaging Studies Open
INTRODUCTION Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied th…
View article: Baseline [18F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease
Baseline [18F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease Open
View article: Baseline correlations between [<sup>18</sup>F]GTP1 PET SUVR and MRI white matter hyperintensities in prodromal‐to‐mild Alzheimer's disease suggest independent contributions to cognitive impairment
Baseline correlations between [<sup>18</sup>F]GTP1 PET SUVR and MRI white matter hyperintensities in prodromal‐to‐mild Alzheimer's disease suggest independent contributions to cognitive impairment Open
Background White matter hyperintensities (WMH) on MRI are commonly seen in Alzheimer’s disease (AD) and thought to represent co‐morbid microvascular ischemic disease. However, the relationship between WMH and tau pathology in AD remains in…
View article: Cognitive indices correlate with [<sup>18</sup>F]GTP1 tau PET signal and white matter hyperintensities in prodromal‐to‐mild Alzheimer's disease: Baseline data from the Tauriel Study
Cognitive indices correlate with [<sup>18</sup>F]GTP1 tau PET signal and white matter hyperintensities in prodromal‐to‐mild Alzheimer's disease: Baseline data from the Tauriel Study Open
Background In prior cross‐sectional studies using [ 18 F]GTP1 or other tau PET tracers across a spectrum of Alzheimer’s disease (AD) severity, tau PET signal has independently correlated with cognition, even after adjustments for β‐amyloid…
View article: Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage Open
View article: Development of AITC‐induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin
Development of AITC‐induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin Open
Background and Purpose Develop a translational assay of Transient Receptor Potential Ankyrin 1 (TRPA1) activity for use as a preclinical and clinical biomarker. Experimental Approach Allyl isothiocyanate (AITC), capsaicin or citric acid we…
View article: GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models Open
View article: Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology
Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology Open
To date, there is no validated fluid biomarker for tau pathology in Alzheimer’s disease, with contradictory results from studies evaluating the correlation between phosphorylated tau in CSF with tau PET imaging. Tau protein is subjected to…
View article: CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions
CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions Open
Microglia are specialized brain macrophages that play numerous roles in tissue homeostasis and response to injury. Colony stimulating factor 1 receptor (CSF1R) is a receptor tyrosine kinase required for the development, maintenance, and pr…
View article: Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer Open
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central ner…
View article: Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Disruption of IRE1α through its kinase domain attenuates multiple myeloma Open
Significance Multiple myeloma (MM) is a lethal malignancy arising from plasma cells. MM cells experience endoplasmic reticulum (ER) stress due to immunoglobulin hyperproduction. The ER-resident sensor IRE1α mitigates ER stress by expanding…
View article: Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease
Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease Open
The regional relationships between tau positron emission tomography (PET) imaging and cognitive impairment in Alzheimer's disease (AD) remain uncertain. We examined cross-sectional associations between cognitive performance, cerebral uptak…
View article: Disruption of IRElα through its Kinase Domain Attenuates Multiple Myeloma
Disruption of IRElα through its Kinase Domain Attenuates Multiple Myeloma Open
Multiple myeloma (MM) arises from malignant immunoglobulin-secreting plasma cells and remains an incurable, often lethal disease despite recent therapeutic advances. The unfolded-protein response sensor IRE1α supports protein secretion by …
View article: Publisher Correction: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy
Publisher Correction: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy Open
View article: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy
Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy Open
View article: [P2–367]: CROSS‐SECTIONAL CORRELATION BETWEEN GTP1‐TAU‐PET AND CSF TAU AS MEASURES OF TAU BURDEN IN ALZHEIMER's DISEASE
[P2–367]: CROSS‐SECTIONAL CORRELATION BETWEEN GTP1‐TAU‐PET AND CSF TAU AS MEASURES OF TAU BURDEN IN ALZHEIMER's DISEASE Open
Intracellular neurofibrillary tangles, composed primarily of aggregated tau protein, are one of the hallmarks of Alzheimer's disease (AD). The burden of tau pathology correlates with disease severity and cognitive decline in AD patients. […
View article: Kinetic Modeling of the Tau PET Tracer <sup>18</sup>F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects
Kinetic Modeling of the Tau PET Tracer <sup>18</sup>F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects Open
18F-AV-1451 is currently the most widely used of several experimental tau PET tracers. The objective of this study was to evaluate 18F-AV-1451 binding with full kinetic analysis using a metabolite-corrected arterial i…
View article: A comparison of retinal layer changes in diabetic mouse models using spectral-domain optical coherence tomography (SDOCT)
A comparison of retinal layer changes in diabetic mouse models using spectral-domain optical coherence tomography (SDOCT) Open
View article: IL-33 amplifies an innate immune response in the degenerating retina
IL-33 amplifies an innate immune response in the degenerating retina Open
Age-related macular degeneration (AMD), a leading cause of vision impairment in the ageing population, is characterized by irreversible loss of retinal pigment epithelial (RPE) cells and photoreceptors and can be associated with choroidal …
View article: Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies Open