Robby Nieuwlaat
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View article: Corrigendum to GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses [Journal of Clinical Epidemiology 81 (2024) 111494]
Corrigendum to GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses [Journal of Clinical Epidemiology 81 (2024) 111494] Open
View article: Standardizing health outcomes for people with rheumatoid arthritis receiving disease modifying drug therapy: A rapid review of patient-decision aids and preference studies to inform the development of OMERACT Health Outcome Descriptors
Standardizing health outcomes for people with rheumatoid arthritis receiving disease modifying drug therapy: A rapid review of patient-decision aids and preference studies to inform the development of OMERACT Health Outcome Descriptors Open
View article: An international guideline training and certification programme
An international guideline training and certification programme Open
View article: Enhancing health equity considerations in guidelines: health equity extension of the GIN-McMaster Guideline Development Checklist
Enhancing health equity considerations in guidelines: health equity extension of the GIN-McMaster Guideline Development Checklist Open
This project was partially funded by Public Health Agency of Canada. The funder was not involved in the conceptualization or design or the conduct of the project.
View article: Patient preferences for drug therapy in inflammatory arthritis: protocol for a living systematic review and evidence map to inform clinical practice guidelines
Patient preferences for drug therapy in inflammatory arthritis: protocol for a living systematic review and evidence map to inform clinical practice guidelines Open
Introduction The pharmacological management of inflammatory arthritis often requires choices that involve trade-offs between benefits, risks and other attributes such as administration route, frequency and cost. This living systematic revi…
View article: Defining decision thresholds for judgments on health benefits and harms using the grading of recommendations assessment, development, and evaluation (GRADE) evidence to decision (EtD) frameworks: a randomized methodological study (GRADE-THRESHOLD)
Defining decision thresholds for judgments on health benefits and harms using the grading of recommendations assessment, development, and evaluation (GRADE) evidence to decision (EtD) frameworks: a randomized methodological study (GRADE-THRESHOLD) Open
Decision thresholds (DTs) help with determining if effects of interventions should be considered absent, small, moderate or large. In this study we derived an overarching approach for these thresholds across conditions and outcomes. The re…
View article: American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary
American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary Open
Background COVID-19–related critical and acute illness is associated with an increased risk of venous thromboembolism (VTE). These evidence-based recommendations of the American Society of Hematology (ASH) are intended to support patients,…
View article: GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses
GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses Open
View article: The INGUIDE International Guideline Training and Certification Programme
The INGUIDE International Guideline Training and Certification Programme Open
Health guidelines impact clinical, public health and policy practice, but there is no regulation for their development, often leading to variability in quality and trustworthiness. The International Guideline Training and Certification Pro…
View article: Representation of published core outcome sets in practice guidelines
Representation of published core outcome sets in practice guidelines Open
There is no evidence that COS are being used routinely to inform the guideline development process, and concordance between outcomes in published guidelines and those in COS is limited. Further work is warranted to explore barriers and fac…
View article: Antibiotic prescribing guideline recommendations in COVID-19: a systematic survey
Antibiotic prescribing guideline recommendations in COVID-19: a systematic survey Open
View article: Table of Contents
Table of Contents Open
View article: American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing
American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing Open
Background Hereditary and acquired thrombophilia are risk factors for venous thromboembolism (VTE). Whether testing helps guide management decisions is controversial. Objective These evidence-based guidelines from the American Society of H…
View article: Proposed triggers for retiring a living systematic review
Proposed triggers for retiring a living systematic review Open
Living systematic reviews (LSRs) are systematic reviews that are continually updated, incorporating relevant new evidence as it becomes available. LSRs are critical for decision-making in topics where the evidence continues to evolve. It i…
View article: Representation of Published Core Outcome Sets in Practice Guidelines
Representation of Published Core Outcome Sets in Practice Guidelines Open
View article: GRADE guidance 35: update on rating imprecision for assessing contextualized certainty of evidence and making decisions
GRADE guidance 35: update on rating imprecision for assessing contextualized certainty of evidence and making decisions Open
View article: American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients Open
Background: COVID-19–related critical illness is associated with an increased risk of venous thromboembolism (VTE). Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, cl…
View article: American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients Open
Background: COVID-19–related acute illness is associated with an increased risk of venous thromboembolism (VTE). Objective: These evidence-based guidelines from the American Society of Hematology (ASH) are intended to support patients, cli…
View article: Which actionable statements qualify as good practice statements In Covid-19 guidelines? A systematic appraisal
Which actionable statements qualify as good practice statements In Covid-19 guidelines? A systematic appraisal Open
Objectives To evaluate the development and quality of actionable statements that qualify as good practice statements (GPS) reported in COVID-19 guidelines. Design and setting Systematic review . We searched MEDLINE, MedSci, China National …
View article: Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance
Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance Open
An evidence-based approach is considered the gold standard for health decision-making. Sometimes, a guideline panel might judge the certainty that the desirable effects of an intervention clearly outweigh its undesirable effects as high, b…
View article: An evaluation of the COVID-19 recommendation map identified diverging clinical and public health guidance
An evaluation of the COVID-19 recommendation map identified diverging clinical and public health guidance Open
View article: In-Hospital Macro-, Meso-, and Micro-Drivers and Interventions for Antibiotic Use and Resistance: A Rapid Evidence Synthesis of Data from Canada and Other OECD Countries
In-Hospital Macro-, Meso-, and Micro-Drivers and Interventions for Antibiotic Use and Resistance: A Rapid Evidence Synthesis of Data from Canada and Other OECD Countries Open
Hospitals continue to face challenges in reducing incorrect antibiotic use due to social and cultural factors at the level of the health system, the care facility, the provider, and the patient. The objective of this paper is to highlight …
View article: Table of Contents
Table of Contents Open
View article: American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis Open
Background COVID-19–related acute illness is associated with an increased risk of venous thromboembolism (VTE). Objective These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinici…
View article: Cost-effectiveness of diagnostic strategies for venous thromboembolism: a systematic review
Cost-effectiveness of diagnostic strategies for venous thromboembolism: a systematic review Open
Guideline developers consider cost-effectiveness evidence in decision making to determine value for money. This consideration in the guideline development process can be informed either by formal and dedicated economic evaluations or by sy…
View article: Table of Contents
Table of Contents Open
View article: How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines
How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines Open
Trustworthy health guidelines should provide recommendations, document the development process, and highlight implementation information. Our objective was to develop a guideline manuscript template to help authors write a complete and use…
View article: American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients Open
Background: COVID-19–related critical illness is associated with an increased risk of venous thromboembolism (VTE). Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, cl…
View article: Systematic review of treatment gaps in oral anticoagulant use in atrial fibrillation
Systematic review of treatment gaps in oral anticoagulant use in atrial fibrillation Open
Aims: Guidelines endorse long-term oral anticoagulation (OAC) for stroke prophylaxis in patients with atrial fibrillation (AF) and additional stroke risk factors. However, diverse estimates of guideline based OAC treatment are reported. Th…
View article: Canadian Rheumatology Association Recommendation for the Use of COVID-19 Vaccination for Patients With Autoimmune Rheumatic Diseases
Canadian Rheumatology Association Recommendation for the Use of COVID-19 Vaccination for Patients With Autoimmune Rheumatic Diseases Open
Objective To develop guidance on the use of coronavirus disease 2019 (COVID-19) vaccines in patients with autoimmune rheumatic diseases (ARD). Methods The Canadian Rheumatology Association (CRA) formed a multidisciplinary panel including r…