Robbyn Issner
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View article: High-throughput <i>in silico</i> screen uncovers key regulators of 3D genome architecture
High-throughput <i>in silico</i> screen uncovers key regulators of 3D genome architecture Open
The vertebrate genome is spatially organized into topologically associating domains (TADs), primarily via cohesin-mediated loop extrusion which typically halts at convergent CTCF binding sites to establish domain boundaries. However, despi…
View article: Multi-locus CRISPRi targeting with a single truncated guide RNA
Multi-locus CRISPRi targeting with a single truncated guide RNA Open
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate …
View article: Multi-locus CRISPRi targeting with a single truncated guide RNA
Multi-locus CRISPRi targeting with a single truncated guide RNA Open
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate …
View article: Supplementary Figure S2 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S2 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S2. Quantitative RT-PCR evaluation of lymphoma samples.
View article: Supplementary Figure S5 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S5 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S5. Additional details regarding candidate MYC enhancers identified in B cell lymphomas.
View article: Supplementary Table S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Table S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Table S4. Sequences of oligonucleotides used for qRT-PCR, RT-PCR, and 3C.
View article: Data from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Data from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel approach called “pinpointing enhancer-associated rearrangements by chromatin immunoprec…
View article: Supplementary Figure S5 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S5 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S5. Additional details regarding candidate MYC enhancers identified in B cell lymphomas.
View article: Supplementary Figure S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S3. Enhancer looping interactions and TF binding at BCL6 enhancers.
View article: Supplementary Figure S2 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S2 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S2. Quantitative RT-PCR evaluation of lymphoma samples.
View article: Supplementary Table S1 - S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Table S1 - S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Table S1. Clinical and diagnostic information on lymphoma cases. Supplementary Table S2. Rearrangements detected by PEAR-ChIP in 14 lymphoma primary samples and 8 lymphoma cell lines. Supplementary Table S3. Detection of larg…
View article: Supplementary Table S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Table S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Table S4. Sequences of oligonucleotides used for qRT-PCR, RT-PCR, and 3C.
View article: Supplementary Figure S1 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S1 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S1. H3K27ac ChIP-Seq tracks and position of rearrangements of possible oncogenic significance detected by PEAR-ChIP. Red bars join discordant intra-chromosomal read pairs.
View article: Supplementary Figure S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S4. Genome-wide correlation and motif analysis of MEF2B and p300 ChIP-Seq in HGB cell lines.
View article: Supplementary Figure S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S4 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S4. Genome-wide correlation and motif analysis of MEF2B and p300 ChIP-Seq in HGB cell lines.
View article: Supplementary Figure S1 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S1 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S1. H3K27ac ChIP-Seq tracks and position of rearrangements of possible oncogenic significance detected by PEAR-ChIP. Red bars join discordant intra-chromosomal read pairs.
View article: Supplementary Methods, Figure Legends, Table Legends from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Methods, Figure Legends, Table Legends from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Methods, Figure Legends, Table Legends
View article: Supplementary Figure S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Figure S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Figure S3. Enhancer looping interactions and TF binding at BCL6 enhancers.
View article: Data from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Data from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel approach called “pinpointing enhancer-associated rearrangements by chromatin immunoprec…
View article: Supplementary Table S1 - S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Table S1 - S3 from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Table S1. Clinical and diagnostic information on lymphoma cases. Supplementary Table S2. Rearrangements detected by PEAR-ChIP in 14 lymphoma primary samples and 8 lymphoma cell lines. Supplementary Table S3. Detection of larg…
View article: Supplementary Methods, Figure Legends, Table Legends from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Supplementary Methods, Figure Legends, Table Legends from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
Supplementary Methods, Figure Legends, Table Legends
View article: The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models
The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models Open
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of 1,635 open-access datasets fr…
View article: Multi-tissue integrative analysis of personal epigenomes
Multi-tissue integrative analysis of personal epigenomes Open
Evaluating the impact of genetic variants on transcriptional regulation is a central goal in biological science that has been constrained by reliance on a single reference genome. To address this, we constructed phased, diploid genomes for…
View article: Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma Open
B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel approach called “pinpointing enhancer-associated rearrangements by chromatin immunoprec…