Robert A. Bray
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View article: 18 A one-year retrospective review of virtual crossmatches performed for deceased-donor kidney offers
18 A one-year retrospective review of virtual crossmatches performed for deceased-donor kidney offers Open
For every available deceased-donor kidney (DDK), the United Network for Organ Sharing generates a “match run” list, where eligible recipient candidates receive a sequence number (seqNo.) by order of priority. As part of the process to eval…
View article: Antigen quantity is responsible for the discrepancy between phenotype and single antigen beads for the detection of human leukocyte antigen DQ antibody: Potential clinical implications
Antigen quantity is responsible for the discrepancy between phenotype and single antigen beads for the detection of human leukocyte antigen DQ antibody: Potential clinical implications Open
De novo donor-specific human leukocyte antigen DQ antibodies detected by single antigen beads (SAB) are significantly associated with chronic antibody-mediated rejection and lower overall graft survival. However, some DQ antibodies identif…
View article: A Tutorial on Teaching Data Analytics with Generative AI
A Tutorial on Teaching Data Analytics with Generative AI Open
This tutorial addresses the challenge of incorporating large language models (LLMs), such as ChatGPT, in a data analytics class. It details several new in-class and out-of-class teaching techniques enabled by AI. For example, instructors c…
View article: HLA class I peptide polymorphisms contribute to class II DQβ0603:DQα0103 antibody specificity
HLA class I peptide polymorphisms contribute to class II DQβ0603:DQα0103 antibody specificity Open
Antibodies reactive to human leukocyte antigens (HLA) represent a barrier for patients awaiting transplantation. Based on reactivity patterns in single-antigen bead (SAB) assays, various epitope matching algorithms have been proposed to im…
View article: The evolving use of biomarkers in heart transplantation: Consensus of an expert panel
The evolving use of biomarkers in heart transplantation: Consensus of an expert panel Open
View article: COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort
COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort Open
View article: Establishing a combined Immunology/HLA/Coagulation Rotation for Pathology Residents
Establishing a combined Immunology/HLA/Coagulation Rotation for Pathology Residents Open
Given the breath of subspecialties within Clinical Pathology (CP), creating a curriculum with adequate exposure to all areas is challenging. Immunology, coagulation, and HLA rotations have been cited repeatedly by pathology trainees at our…
View article: Development of donor specific antibodies after SARS-CoV-2 vaccination in kidney and heart transplant recipients
Development of donor specific antibodies after SARS-CoV-2 vaccination in kidney and heart transplant recipients Open
This study examined the development of new or changes in donor specific antibodies (DSA) mean-fluorescence intensity (MFI) after SARS-CoV-2 vaccination in 100 kidney and 50 heart transplant recipients. The study was performed when the Cent…
View article: COVID-19 Infection Does Not Alter HLA Antibody Reactivity
COVID-19 Infection Does Not Alter HLA Antibody Reactivity Open
View article: hlaR: A rapid and reproducible tool to identify eplet mismatches between transplant donors and recipients
hlaR: A rapid and reproducible tool to identify eplet mismatches between transplant donors and recipients Open
View article: Employment status at transplant influences ethnic disparities in outcomes after deceased donor kidney transplantation
Employment status at transplant influences ethnic disparities in outcomes after deceased donor kidney transplantation Open
View article: Factors Influencing Ethnic Disparities in Outcomes after Deceased Donor Kidney Transplantation
Factors Influencing Ethnic Disparities in Outcomes after Deceased Donor Kidney Transplantation Open
Background: African American (AA) recipients of deceased-donor (DD) kidney transplants (KT) have shorter allograft survival than recipients of other ethnic groups. Reasons for this disparity encompass complex interactions between donors an…
View article: Eplet mismatch imputation studies should include immunologic risk assessment
Eplet mismatch imputation studies should include immunologic risk assessment Open
To the Editor: HLA eplet mismatch analysis represents the evolution from antigen-level match assessments and cell-based donor-specific antibody (DSA) identification to an integrated approach combining sophisticated molecular histocompatibi…
View article: Development and Validation of a Multiplex, Bead-based Assay to Detect Antibodies Directed Against SARS-CoV-2 Proteins
Development and Validation of a Multiplex, Bead-based Assay to Detect Antibodies Directed Against SARS-CoV-2 Proteins Open
Background. Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining the status of antibodies against SARS-CoV-2 in both candidates and recipients will be important to understand the epid…
View article: The utility of second single antigen bead assay: Clearing the water or stirring up mud?
The utility of second single antigen bead assay: Clearing the water or stirring up mud? Open
View article: Development and validation of a multiplex bead based assay for the detection of antibodies directed against SARS-CoV-2 proteins
Development and validation of a multiplex bead based assay for the detection of antibodies directed against SARS-CoV-2 proteins Open
Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining antibody status against SARS-CoV-2 in candidates and recipients will be important to understand the epidemiology and clinical cour…
View article: Stem cell donor HLA typing improves CPRA in kidney allocation
Stem cell donor HLA typing improves CPRA in kidney allocation Open
View article: Identification of a recurrent pattern of false-positivity by Luminex HLA MHC class I single antigen bead testing
Identification of a recurrent pattern of false-positivity by Luminex HLA MHC class I single antigen bead testing Open
View article: The impact of transfused blood products on deceased donor HLA typing
The impact of transfused blood products on deceased donor HLA typing Open
View article: Out with the old, in with the new: Virtual versus physical crossmatching in the modern era
Out with the old, in with the new: Virtual versus physical crossmatching in the modern era Open
The virtual crossmatch (VXM) is gaining acceptance as an alternative approach to assess donor:recipient compatibility prior to transplantation. In contrast to a physical crossmatch, the virtual crossmatch does not require viable donor cell…
View article: A precision virtual crossmatch decision support system for interpretation of ambiguous molecular HLA typing data
A precision virtual crossmatch decision support system for interpretation of ambiguous molecular HLA typing data Open
Virtual crossmatch (VXM) compares a transplant candidate’s unacceptable antigens to the HLA typing of the donor before an organ offer is accepted and, in selected cases, supplant a prospective physical crossmatch. However, deceased donor t…
View article: The impact of belatacept on third-party HLA alloantibodies in highly sensitized kidney transplant recipients
The impact of belatacept on third-party HLA alloantibodies in highly sensitized kidney transplant recipients Open
View article: Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants
Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants Open
In an analysis of biopsies from an apparently homogeneous group of stable, long-term pediatric liver transplant recipients with consistently normal liver test results, we found evidence of chronic graft injury (inflammation and/or fibrosis…
View article: Mapping molecular HLA typing data to UNOS antigen equivalents
Mapping molecular HLA typing data to UNOS antigen equivalents Open
Computer-assisted interpretation of molecular HLA data may aid in reducing typing discrepancies in UNet. This work also sets a foundation for molecular typing data to be utilized directly in the UNet match run as well as the virtual crossm…
View article: Mapping molecular HLA typing data to UNOS antigen equivalents for improved virtual crossmatch
Mapping molecular HLA typing data to UNOS antigen equivalents for improved virtual crossmatch Open
Background Virtual crossmatch utilizes HLA typing and antibody screen assay data as a part of organ offers in deceased donor allocation systems. Histocompatibility labs must convert molecular HLA typings to antigen equivalencies for entry …
View article: Comparison of de novo IgM and IgG anti-HLA DSAs between belatacept- and calcineurin-treated patients: An analysis of the BENEFIT and BENEFIT-EXT trial cohorts
Comparison of de novo IgM and IgG anti-HLA DSAs between belatacept- and calcineurin-treated patients: An analysis of the BENEFIT and BENEFIT-EXT trial cohorts Open
Preventing conversion of donor-specific anti-HLA antibodies (DSAs) from an IgM-to-IgG could a way to prevent chronic rejection. We evaluated whether belatacept-treated patients (belatacept less-intensive [LI] or more-intensive [MI] regimen…
View article: Posttransplant reduction in preexisting donor-specific antibody levels after belatacept- versus cyclosporine-based immunosuppression: Post hoc analyses of BENEFIT and BENEFIT-EXT
Posttransplant reduction in preexisting donor-specific antibody levels after belatacept- versus cyclosporine-based immunosuppression: Post hoc analyses of BENEFIT and BENEFIT-EXT Open
View article: De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies
De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies Open
View article: Understanding solid-phase HLA antibody assays and the value of MFI
Understanding solid-phase HLA antibody assays and the value of MFI Open
View article: Genotyping Applications for Transplantation and Transfusion Management: The Emory Experience
Genotyping Applications for Transplantation and Transfusion Management: The Emory Experience Open
Current genotyping methodologies for transplantation and transfusion management employ multiplex systems that allow for simultaneous detection of multiple HLA antigens, human platelet antigens, and red blood cell (RBC) antigens. The develo…