Robert A. Budinsky
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View article: Influence of recording instrumentation on measurements of voice in sentence contexts: use of smartphones and tablets
Influence of recording instrumentation on measurements of voice in sentence contexts: use of smartphones and tablets Open
Introduction The Bridge2AI-Voice. Consortium is developing affordable and accessible voice data to assist in the identification of vocal biomarkers of disease in adults and children. Initial experiments were designed to establish voice rec…
View article: Validity of Acoustic Measures Obtained Using Various Recording Methods Including Smartphones With and Without Headset Microphones
Validity of Acoustic Measures Obtained Using Various Recording Methods Including Smartphones With and Without Headset Microphones Open
Purpose: The goal of this study was to assess various recording methods, including combinations of high- versus low-cost microphones, recording interfaces, and smartphones in terms of their ability to produce commonly used time- and spectr…
View article: An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents
An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents Open
1,4-Dioxane is an environmental contaminant that has been shown to cause cancer in rodents after chronic high dose exposures. We reviewed and integrated information from recently published studies to update our understanding of the cancer …
View article: An updated lymphohematopoietic and bladder cancers risk evaluation for occupational and environmental exposures to 1,3-butadiene
An updated lymphohematopoietic and bladder cancers risk evaluation for occupational and environmental exposures to 1,3-butadiene Open
EPA designated 1,3-butadiene (BD) as a high priority chemical in December 2019 and is presently performing an evaluation under the Toxic Substances Control Act (TSCA). EPA's cancer dose-response assessment for BD was published in 2002 and …
View article: A Comparison of Environment Classification Among Premium Hearing Instruments
A Comparison of Environment Classification Among Premium Hearing Instruments Open
Hearing aids classify acoustic environments into multiple, generic classes for the purposes of guiding signal processing. Information about environmental classification is made available to the clinician for fitting, counseling, and troubl…
View article: Development of a Range of Plausible Noncancer Toxicity Values for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Based on Effects on Sperm Count: Application of Systematic Review Methods and Quantitative Integration of Dose Response Using Meta-Regression
Development of a Range of Plausible Noncancer Toxicity Values for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Based on Effects on Sperm Count: Application of Systematic Review Methods and Quantitative Integration of Dose Response Using Meta-Regression Open
Regulatory agencies have derived noncancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin based on reduced sperm counts relying on single studies from a large body of evidence. Techniques such as meta-regression allow for greater …
View article: A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane
A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane Open
Studies demonstrate that with sufficient dose and duration, 1,4-dioxane (1,4-DX) induces liver tumors in laboratory rodent models. The available evidence aligns with a threshold-dependent, tumor promotion mode of action (MOA). The MOA and …
View article: Response to the comments of Runyan et al. on “Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats”
Response to the comments of Runyan et al. on “Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats” Open
As stated in our Introduction, DeSesso et al. (2019) attempted to replicate the Johnson, Goldberg, Mays, and Dawson (2003) trichloroethylene (TCE) drinking water study in pregnant rats, which reported “abnormal hearts” among offspring of t…
View article: Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin Open
Increasing interest in characterizing risk assessment uncertainty is highlighted by recent recommendations from the National Academy of Sciences. In this paper we demonstrate the utility of applying qualitative and quantitative methods for…
View article: Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats
Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats Open
Background Trichloroethylene (TCE) was negative for developmental toxicity after inhalation and oral gavage exposure of pregnant rats but fetal cardiac defects were reported following drinking water exposure throughout gestation. Because o…
View article: Quantitative analysis of unconjugated and total bisphenol A in human urine using solid-phase extraction and UPLC–MS/MS: Method implementation, method qualification and troubleshooting
Quantitative analysis of unconjugated and total bisphenol A in human urine using solid-phase extraction and UPLC–MS/MS: Method implementation, method qualification and troubleshooting Open
The aim of the presented investigation was to document challenges encountered during implementation and qualification of a method for bisphenol A (BPA) analysis and to develop and discuss precautions taken to avoid and to monitor contamina…
View article: The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor
The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor Open
An Adverse Outcome Pathway (AOP) represents the existing knowledge of a biological pathway leading from initial molecular interactions of a toxicant and progressing through a series of key events (KEs), culminating with an apical adverse o…
View article: A Model for Aryl Hydrocarbon Receptor-Activated Gene Expression Shows Potency and Efficacy Changes and Predicts Squelching Due to Competition for Transcription Co-Activators
A Model for Aryl Hydrocarbon Receptor-Activated Gene Expression Shows Potency and Efficacy Changes and Predicts Squelching Due to Competition for Transcription Co-Activators Open
A stochastic model of nuclear receptor-mediated transcription was developed based on activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and subsequent binding the activated AHR to xenobiotic respon…
View article: Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration
Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration Open
Orally administered bisphenol A (BPA) undergoes efficient first-pass metabolism to produce the inactive conjugates BPA-glucuronide (BPA-G) and BPA-sulfate (BPA-S). This study was conducted to evaluate the pharmacokinetics of BPA, BPA-G and…
View article: Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes
Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes Open
An adverse outcome pathway (AOP) describes the causal linkage between initial molecular events and an adverse outcome at individual or population levels. Whilst there has been considerable momentum in AOP development, far less attention ha…