Robert A. Gibson
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View article: Maternal phthalate exposure, gestational length, and preterm birth risk: a prospective cohort study nested within a randomised trial
Maternal phthalate exposure, gestational length, and preterm birth risk: a prospective cohort study nested within a randomised trial Open
Background Preterm birth (< 37 weeks gestation) is a leading cause of infant morbidity and mortality, yet the underlying causes remain unknown in many cases. Environmental exposures, including endocrine-disrupting chemicals such as phthala…
View article: Enteral High-Dose Docosahexaenoic Acid and Neurodevelopment in Extremely Preterm Infants: A Systematic Review and Meta-analysis
Enteral High-Dose Docosahexaenoic Acid and Neurodevelopment in Extremely Preterm Infants: A Systematic Review and Meta-analysis Open
Enteral high-dose DHA in extremely preterm infants was not associated with differences in global cognition scores on meta-analysis; however, higher scores were observed with the use of a direct emulsion. Results support contemporary recomm…
View article: Feasibility, Implementation and Early Adoption of an Omega-3 Test-and-Treat Program to Reduce Preterm Birth
Feasibility, Implementation and Early Adoption of an Omega-3 Test-and-Treat Program to Reduce Preterm Birth Open
Objective To evaluate the feasibility and early adoption of the Omega-3 Test-and-Treat Program, a targeted intervention to reduce preterm birth in women with low omega-3 levels, implemented within routine antenatal care. Design A prospecti…
View article: To eat or not to eat: novel stable isotope models reveal a shift in carnivory with nutrient availability for aquatic <i>Utricularia</i> spp.
To eat or not to eat: novel stable isotope models reveal a shift in carnivory with nutrient availability for aquatic <i>Utricularia</i> spp. Open
Background and Aims Freshwater nitrogen inputs are increasing globally, altering the structure and function of wetland ecosystems adapted to low nutrient conditions. Carnivorous wetland plants of the genus Utricularia are hypothesized to r…
View article: Gestational PFAS exposure and newborn size: The modifying effect of cord blood fatty acids
Gestational PFAS exposure and newborn size: The modifying effect of cord blood fatty acids Open
View article: Association of cord blood vitamin D with child neurodevelopment at 7 years of age
Association of cord blood vitamin D with child neurodevelopment at 7 years of age Open
Aim The role of fetal vitamin D [25‐hydroxyvitamin D (25(OH)D)], one of the nuclear steroid transcription regulators, and brain development is unclear. We previously found a weak but persistent association between cord blood 25(OH)D and ch…
View article: Infant formula supplemented with milk fat globule membrane compared with standard infant formula for the cognitive development of healthy term-born formula-fed infants: protocol for a randomised controlled trial
Infant formula supplemented with milk fat globule membrane compared with standard infant formula for the cognitive development of healthy term-born formula-fed infants: protocol for a randomised controlled trial Open
Introduction Milk fat globule membrane (MFGM) is a complex lipid–protein structure in mammalian milk and human milk that is largely absent from breastmilk substitutes. The objective of this trial is to investigate whether providing infant …
View article: Plasma Sphingomyelins and Carnitine Esters of Infants Consuming Whole Goat or Cow Milk-Based Infant Formulas or Human Milk
Plasma Sphingomyelins and Carnitine Esters of Infants Consuming Whole Goat or Cow Milk-Based Infant Formulas or Human Milk Open
View article: Assessment of omega-3 and omega-6 fatty acid profiles and ratio of omega-6/omega-3 of white eggs produced by laying hens fed diets enriched with omega-3 rich vegetable oil
Assessment of omega-3 and omega-6 fatty acid profiles and ratio of omega-6/omega-3 of white eggs produced by laying hens fed diets enriched with omega-3 rich vegetable oil Open
The aim of this study was to evaluate the levels of omega-3 (n-3) and omega-6 (n-6) fatty acids in egg and the ratio of n-6/n-3 of white eggs produced by laying hens (Hy-Line white) fed diets enriched with n-3 fats. In this study, alpha-li…
View article: High-Dose Docosahexaenoic Acid in Newborns Born at Less Than 29 Weeks’ Gestation and Behavior at Age 5 Years
High-Dose Docosahexaenoic Acid in Newborns Born at Less Than 29 Weeks’ Gestation and Behavior at Age 5 Years Open
Importance Children born at less than 29 weeks’ gestation are at risk of behavioral difficulties. This may be due in part to the lack of transplacental supply of docosahexaenoic acid (DHA), a key fatty acid with structural and functional r…
View article: B-162 Direct Quantitation of Five Immunosuppressant Drugs in Dried Whole Blood Spots by a Fully Automated DSM-LC-MS System
B-162 Direct Quantitation of Five Immunosuppressant Drugs in Dried Whole Blood Spots by a Fully Automated DSM-LC-MS System Open
Background Liquid chromatography-mass spectrometry (LC-MS) is increasingly used in clinical research to quantify immunosuppressant drugs in whole blood as it can offer higher sensitivity and selectivity than other analytical techniques. LC…
View article: B-307 Direct Quantitation of 77 Therapeutic and Clinical Toxicology Drugs in Dried Blood Spots Using the Fully Automated Transcend DSX-1 System
B-307 Direct Quantitation of 77 Therapeutic and Clinical Toxicology Drugs in Dried Blood Spots Using the Fully Automated Transcend DSX-1 System Open
Background The dried blood spot (DBS) sampling technique is advantageous over the traditional liquid blood collection due to its minimal invasiveness, smaller sample volume, improved analyte stability, and ease of storage and transportatio…
View article: Predictors of compliance with higher dose omega-3 fatty acid supplementation during pregnancy and implications for the risk of prematurity: exploratory analysis of the ORIP randomised trial
Predictors of compliance with higher dose omega-3 fatty acid supplementation during pregnancy and implications for the risk of prematurity: exploratory analysis of the ORIP randomised trial Open
Background Intention-to-treat analyses of the Omega‐3 to Reduce the Incidence of Prematurity (ORIP) trial found that omega-3 (n-3) fatty acid supplementation reduces the risk of prematurity in the subgroup of women with a singleton pregnan…
View article: Mediation Analysis to Untangle Opposing Associations of High-Dose Docosahexaenoic Acid With IQ and Bronchopulmonary Dysplasia in Children Born Preterm
Mediation Analysis to Untangle Opposing Associations of High-Dose Docosahexaenoic Acid With IQ and Bronchopulmonary Dysplasia in Children Born Preterm Open
Importance High-dose omega-3 docosahexaenoic acid (DHA) supplementation of children born at less than 29 weeks’ gestation has been shown to improve IQ despite increasing the risk of bronchopulmonary dysplasia (BPD). Given that BPD is assoc…
View article: Growth of late preterm infants fed nutrient-enriched formula to 120 days corrected age—A randomized controlled trial
Growth of late preterm infants fed nutrient-enriched formula to 120 days corrected age—A randomized controlled trial Open
Objectives We aimed to compare the effects of nutrient-enriched formula with standard term formula on rate of body weight gain of late preterm infants appropriately grown for gestational age. Study design A multi-center, randomized, contro…
View article: Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial
Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial Open
Objectives The risk factors for prematurity are multifactorial and include low omega-3 status. Omega-3 supplementation in pregnancy has been found to reduce prematurity risk, particularly among women with low omega-3 levels. This study aim…
View article: Variable preterm oral microbiome stabilizes and reflects a full-term infant profile within three months
Variable preterm oral microbiome stabilizes and reflects a full-term infant profile within three months Open
View article: Omega-3 content and sensory evaluation of scrambled eggs from two strains of laying hens fed diets enriched with alpha-linolenic acid
Omega-3 content and sensory evaluation of scrambled eggs from two strains of laying hens fed diets enriched with alpha-linolenic acid Open
The objective of the study was to assess the accumulation of omega-3 (n-3) fats and the sensory quality of scrambled eggs from two strains of laying hens (brown and white) given omega-3 enriched diets. The design of this research was a com…
View article: Effect of Docosahexaenoic Acid (DHA) Supplementation of Preterm Infants on Growth, Body Composition, and Blood Pressure at 7-Years Corrected Age: Follow-Up of a Randomized Controlled Trial
Effect of Docosahexaenoic Acid (DHA) Supplementation of Preterm Infants on Growth, Body Composition, and Blood Pressure at 7-Years Corrected Age: Follow-Up of a Randomized Controlled Trial Open
Aim: To determine if supplementation of infants born 0.1). High-DHA group infants were more likely to be classified as obese (relative risk 1.6 (95% CI 1.0, 2.6); p = 0.05). Conclusions: DHA supplementation of premature infants did not af…
View article: Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies
Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies Open
View article: Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 Years
Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 Years Open
In infants born before 29 weeks' gestation who had been enrolled in a trial to assess the effect of DHA supplementation on bronchopulmonary dysplasia, the use of an enteral DHA emulsion until 36 weeks of postmenstrual age was associated wi…
View article: Protocol for a multicentre prospective observational study of families with full-term infants on postnatal wards and in the community to capture feeding practices across the first year of life: the Mother Infant Lactation Questionnaire (MILQ) study
Protocol for a multicentre prospective observational study of families with full-term infants on postnatal wards and in the community to capture feeding practices across the first year of life: the Mother Infant Lactation Questionnaire (MILQ) study Open
Introduction Breastmilk is considered the gold standard for infant nutrition. Breast feeding is recommended as the sole source of nutrition between birth until around 6 months of age and should be continued beyond this age as complementary…
View article: ISSFAL statement number 7 – Omega-3 fatty acids during pregnancy to reduce preterm birth
ISSFAL statement number 7 – Omega-3 fatty acids during pregnancy to reduce preterm birth Open
Globally, preterm birth is the leading cause of death in children under the age of 5 years and survivors may suffer life-long consequences. Following many years of investigation, there is strong evidence that a proportion of preterm births…
View article: Randomized controlled trial of early arachidonic acid and docosahexaenoic acid enteral supplementation in very preterm infants
Randomized controlled trial of early arachidonic acid and docosahexaenoic acid enteral supplementation in very preterm infants Open
Objective To evaluate changes in blood long-chain polyunsaturated fatty acid (LCPUFA) and oxylipin concentrations in very preterm infants from birth to 36 weeks’ postmenstrual age (WPA) after providing an emulsified arachidonic acid (ARA):…
View article: Associations of Maternal Milk Feeding With Neurodevelopmental Outcomes at 7 Years of Age in Former Preterm Infants
Associations of Maternal Milk Feeding With Neurodevelopmental Outcomes at 7 Years of Age in Former Preterm Infants Open
In this cohort study of preterm infants, maternal milk feeding during the neonatal hospitalization and after discharge were associated with better school-age performance IQ and academic achievement and with a reduction in ADHD symptoms, pa…
View article: A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies
A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies Open
Depression is a common mood disorder associated with childbirth and is hypothesized to be affected by low vitamin D. This systematic review identified two randomized controlled trials (RCT) of vitamin D supplementation for the treatment or…
View article: In memory of Allen James Lowrie (1948 – 2021)
In memory of Allen James Lowrie (1948 – 2021) Open
Allen Lowrie memorial.
View article: Omega-3 fatty acid composition of chicken plasma fed diets varying in LA to ALA ratio
Omega-3 fatty acid composition of chicken plasma fed diets varying in LA to ALA ratio Open
The impact of dietary supplementation of a vegetable source of n-3 fat in the form of alpha-linolenic acid (ALA, 18:3n-3) on the accumulation of n-3 fatty acids in plasma chicken was investigated. Sixty unsexed one-day-old broiler chickens…
View article: The Influence of Prenatal DHA Supplementation on Individual Domains of Behavioral Functioning in School-Aged Children: Follow-Up of a Randomized Controlled Trial
The Influence of Prenatal DHA Supplementation on Individual Domains of Behavioral Functioning in School-Aged Children: Follow-Up of a Randomized Controlled Trial Open
Docosahexaenoic acid (DHA) accumulates in the fetal brain during pregnancy and is thought to have a role in supporting neurodevelopment. We conducted a multicenter, double-blind, randomized controlled trial in women with a singleton pregna…
View article: Omega-3 fatty acid levels and sensory quality of eggs following consumptionof alpha-linolenic acid enriched diets
Omega-3 fatty acid levels and sensory quality of eggs following consumptionof alpha-linolenic acid enriched diets Open
The aim of the study was to increase the levels of omega-3 fatty acids in eggs, mainly in the form of eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n -3) as EPA and DHA have beneficial health effects. This study t…