Robert G. Hahn
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View article: Physiology and Molecular Mechanisms of the “Third Fluid Space”
Physiology and Molecular Mechanisms of the “Third Fluid Space” Open
Basic physiology and molecular mechanisms accounting for the maldistribution of fluid that is characteristic of the “third fluid space” (Vt2) have been known for several decades but have been poorly integrated into the clinical literature.…
View article: Effects of concentrated urine on complications and plasma creatinine: a prospective study in elective non-cardiac surgery patients
Effects of concentrated urine on complications and plasma creatinine: a prospective study in elective non-cardiac surgery patients Open
Objectives The urine concentration of metabolic end products increases in response to low habitual water intake or acute dehydration. We examined the impact of concentrated urine on surgical outcomes with special attention given to plasma …
View article: Where does the fluid go?
Where does the fluid go? Open
Background Liberal administration of crystalloid fluid is often required to maintain adequate tissue perfusion when treating life-threatening conditions. Current knowledge indicates that either overhydration or underhydration can promote c…
View article: Constant plasma volume and colloid osmotic pressure after infusion of albumin 20%: A secondary analysis
Constant plasma volume and colloid osmotic pressure after infusion of albumin 20%: A secondary analysis Open
Aberrant elimination patterns after intravenous infusion of albumin 20% may predispose to persistent vascular overload or hyper‐oncoticity. In the present report, the frequency of deviating elimination patterns was studied by visual examin…
View article: Vasoactive drugs and the distribution of crystalloid fluid during acute sepsis
Vasoactive drugs and the distribution of crystalloid fluid during acute sepsis Open
View article: Volume kinetics of crystalloid and colloid solutions administered to healthy anesthetized cats
Volume kinetics of crystalloid and colloid solutions administered to healthy anesthetized cats Open
This prospective experimental study evaluated the disposition of a crystalloid and a colloid solution in 10 healthy cats under general anesthesia. Each cat was randomly assigned to receive either 20 mL/kg of a balanced isotonic crystalloid…
View article: Response to the Letter: “Constructive Evaluation of CATHIS”
Response to the Letter: “Constructive Evaluation of CATHIS” Open
View article: Perioperative fluid therapy in adults and children: a narrative review
Perioperative fluid therapy in adults and children: a narrative review Open
Intravenous fluid administration is an important part of the management of the surgical patient. Fluid can be used to compensate for the normal turnover of fluid and electrolytes (maintenance), to replace losses, to expand the extracellula…
View article: Attenuation of the plasma volume response to crystalloid fluid used for goal-directed fluid therapy
Attenuation of the plasma volume response to crystalloid fluid used for goal-directed fluid therapy Open
Background Goal-directed fluid therapy uses repeated bolus infusions of crystalloid or colloid fluid to increase the plasma volume for the purpose of challenging the patient’s position on the Frank-Starling curve. Each bolus is assumed to …
View article: Influence of awakening from general anesthesia on the distribution of glucose 2.5% with balanced electrolytes in adults
Influence of awakening from general anesthesia on the distribution of glucose 2.5% with balanced electrolytes in adults Open
Background The glucose-free crystalloid fluid used for intravenous infusion during surgery might be combined with or replaced by 2.5% glucose in debilitated patients. The aim of the present study was to use kinetic modeling to quantify the…
View article: Navigating Psychological Riptides: How Seafarers Cope and Seek Help for Mental Health Needs
Navigating Psychological Riptides: How Seafarers Cope and Seek Help for Mental Health Needs Open
This study explored the coping strategies and help-seeking behaviors of Filipino seafarers in addressing their mental health challenges, with a focus on the adoption of telemental health services. Drawing on the Integrated Behavioral Model…
View article: Volume kinetics of lactated Ringer's solution in adult horses
Volume kinetics of lactated Ringer's solution in adult horses Open
Background Fluid therapy in horses is primarily empirical. Evidence‐based quantification of the disposition of intravenous (IV) crystalloids used in clinical practice could enhance the effectiveness of fluid therapy. Objectives To determin…
View article: Plasma Volume Oscillations During Intravenous Infusion of Hyper-Oncotic Albumin
Plasma Volume Oscillations During Intravenous Infusion of Hyper-Oncotic Albumin Open
Low-frequency oscillations of blood components have been observed when the plasma is diluted by crystalloid fluid. The present study explores whether oscillations also occur during the infusion of hyper-oncotic albumin 20%. For this purpos…
View article: Volume Kinetic Analysis in Living Humans: Background History and Answers to 15 Questions in Physiology and Medicine
Volume Kinetic Analysis in Living Humans: Background History and Answers to 15 Questions in Physiology and Medicine Open
Volume kinetics is a pharmacokinetic method for analysis of the distribution and elimination of infusion fluids. The approach has primarily been used to improve the planning of fluid therapy during surgery but is also useful for answering …
View article: Detection of hypovolemia by non-invasive hemodynamic monitoring during major surgery using Ringer´s solution, 5% albumin, or 20% albumin as infusion fluid: a post-hoc analysis of a randomized clinical trial
Detection of hypovolemia by non-invasive hemodynamic monitoring during major surgery using Ringer´s solution, 5% albumin, or 20% albumin as infusion fluid: a post-hoc analysis of a randomized clinical trial Open
NCT05391607, May 26, 2022.
View article: Volume Kinetics of Gelofusine 4% During Vascular Surgery
Volume Kinetics of Gelofusine 4% During Vascular Surgery Open
View article: Estimating the plasma volume by infusing albumin: a retrospective feasibility study
Estimating the plasma volume by infusing albumin: a retrospective feasibility study Open
View article: Volume kinetics in a translational porcine model of stabilized sepsis with fluid accumulation
Volume kinetics in a translational porcine model of stabilized sepsis with fluid accumulation Open
After sepsis, fluid was accumulated in the slow-exchange compartment, and further fluid administration distributed preferentially to the fast-exchange compartment with acceleration of lymph flow, improved plasma expansion, and recruitment …
View article: Editorial: Hemodynamic management and fluid therapy in the perioperative setting
Editorial: Hemodynamic management and fluid therapy in the perioperative setting Open
View article: Capillary Filtration of Plasma Is Accelerated During General Anesthesia: A Secondary Population Volume Kinetic Analysis
Capillary Filtration of Plasma Is Accelerated During General Anesthesia: A Secondary Population Volume Kinetic Analysis Open
How infusion fluids are distributed and eliminated is of importance to how much and how fast they should be administered. This manuscript applies population pharmacokinetic modeling to intravenous infusions of crystalloid fluid, which is a…
View article: Low-grade hemodilution improves the microcirculatory function in surgical patients
Low-grade hemodilution improves the microcirculatory function in surgical patients Open
Plasma dilution of up to 15 % increased the vessel density, and the capillary filtration increased by more than suggested by the volume expansion. Dilution >15 % had a negative influence on these variables.
View article: Diuretic responses to Ringer's solution and 20% albumin at different arterial pressures
Diuretic responses to Ringer's solution and 20% albumin at different arterial pressures Open
Intravenous volume loading is a common treatment when hypovolemia is a potential cause of oliguria. We studied whether the effectiveness of Ringer's solution and 20% albumin in inducing diuresis differs depending on the mean arterial press…
View article: Do volatile anaesthetics depress urine output?
Do volatile anaesthetics depress urine output? Open
Introduction Urine output is markedly reduced by isoflurane, but it is unclear whether the decrease is a specific effect of volatile anaesthetics. Therefore, this study compared the diuretic response to crystalloid volume loading during su…
View article: Sequential recruitment of body fluid spaces for increasing volumes of crystalloid fluid
Sequential recruitment of body fluid spaces for increasing volumes of crystalloid fluid Open
Introduction The interstitial space harbours two fluid compartments linked serially to the plasma. This study explores conditions that lead to fluid accumulation in the most secluded compartment, termed the “third space”. Methods Retrospec…
View article: Is the NICE Guideline for maintenance fluid therapy in adults in hospital appropriate?
Is the NICE Guideline for maintenance fluid therapy in adults in hospital appropriate? Open
EudraCT 2016-001846-24 and ISRCTN 12215472.
View article: Fluid distribution during surgery in the flat recumbent, Trendelenburg, and the reverse Trendelenburg body positions
Fluid distribution during surgery in the flat recumbent, Trendelenburg, and the reverse Trendelenburg body positions Open
Background The distribution and elimination of infused crystalloid fluid is known to be affected by general anesthesia, but it is unclear whether changes differ depending on whether the patient is operated in the flat recumbent position, t…
View article: Accelerated lymph flow from infusion of crystalloid fluid during general anesthesia
Accelerated lymph flow from infusion of crystalloid fluid during general anesthesia Open
Background Kinetic analysis of crystalloid fluid yields a central distribution volume ( V c ) of the same size as the expected plasma volume (approximately 3 L) except during general anesthesia during which V c might be only half as large.…
View article: Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial
Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial Open
View article: Detection of low urine output by measuring urinary biomarkers
Detection of low urine output by measuring urinary biomarkers Open
View article: Additional file 1 of Detection of low urine output by measuring urinary biomarkers
Additional file 1 of Detection of low urine output by measuring urinary biomarkers Open
Supplementary Material 1: Original data in the diet study. Lines 1–82 show the measurements performed during the first 4 days of the study, when water intake was habitual, and Lines 84–162 show the second period (Days 8–11) when the ingest…