Robert A. Kowatch
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View article: Systematic Review and Network Meta-Analysis: Efficacy and Safety of Antipsychotics vs Antiepileptics or Lithium for Acute Mania in Children and Adolescents
Systematic Review and Network Meta-Analysis: Efficacy and Safety of Antipsychotics vs Antiepileptics or Lithium for Acute Mania in Children and Adolescents Open
Efficacy and Safety of Antipsychotics vs Antiepileptics or Lithium Used for Mood Stabilization in Bipolar Disorder in Children and Adolescents: A Systematic Review and Exploratory Network Meta-analysis of Head-to-Head Trials; https://www.c…
View article: Diagnostic Efficiency of Caregiver Report on the SCARED for Identifying Youth Anxiety Disorders in Outpatient Settings
Diagnostic Efficiency of Caregiver Report on the SCARED for Identifying Youth Anxiety Disorders in Outpatient Settings Open
This study investigated the diagnostic and clinical utility of the parent-rated Screen for Child Anxiety Related Emotional Disorders (SCARED-P) for detecting youth anxiety disorders. Youth ages 6 to 12 years, 11 months were recruited from …
View article: Characteristics of Children With Elevated Symptoms of Mania: The Longitudinal Assessment of Manic Symptoms (LAMS) Study
Characteristics of Children With Elevated Symptoms of Mania: The Longitudinal Assessment of Manic Symptoms (LAMS) Study Open
To examine differences in psychiatric symptomatology, diagnoses, demographics, functioning, and psychotropic medication exposure in children with elevated symptoms of mania (ESM+) compared to youth without ESM (ESM−).
View article: The Relationship of Persistent Manic Symptoms to the Diagnosis of Pediatric Bipolar Disorder
The Relationship of Persistent Manic Symptoms to the Diagnosis of Pediatric Bipolar Disorder Open
The diagnosis of Bipolar Spectrum Disorders (BPSDs; Bipolar I and II, Cyclothymic Disorder, and Bipolar NOS) in youth remains controversial. The present study evaluated the possibility that the presence of persistent manic symptoms over a …
View article: Longitudinal Assessment of Manic Symptoms (LAMS) Study: Background, Design, and Initial Screening Results
Longitudinal Assessment of Manic Symptoms (LAMS) Study: Background, Design, and Initial Screening Results Open
To describe the design of a longitudinal study of youth with elevated symptoms of mania (ESM) as well as the prevalence and correlates of manic symptoms. Bipolar disorder in youth is serious and is surrounded by controversy about its pheno…
View article: Use of Outpatient Mental Health Services Among Children of Different Ages: Are Younger Children More Seriously Ill?
Use of Outpatient Mental Health Services Among Children of Different Ages: Are Younger Children More Seriously Ill? Open
The study compared use of specialty outpatient mental services among children ages six and seven and children ages eight through 12 and investigated predictors of differences in the patterns of service use by age.
View article: Prescription of Psychiatric Medications and Polypharmacy in the LAMS Cohort
Prescription of Psychiatric Medications and Polypharmacy in the LAMS Cohort Open
This study evaluated demographic and clinical correlates and predictors of polypharmacy at baseline assessment in the Longitudinal Assessment of Manic Symptoms (LAMS) sample, a cohort of children age six to 12 years at their first outpatie…
View article: Decreased amygdala–insula resting state connectivity in behaviorally and emotionally dysregulated youth
Decreased amygdala–insula resting state connectivity in behaviorally and emotionally dysregulated youth Open
The Research Domain Criteria (RDoC) adopts a dimensional approach for examining pathophysiological processes underlying categorically defined psychiatric diagnoses. We used this framework to examine relationships among symptom dimensions, …
View article: First-Dose Pharmacokinetics of Lithium Carbonate in Children and Adolescents
First-Dose Pharmacokinetics of Lithium Carbonate in Children and Adolescents Open
Bipolar I disorder (BP-I) in children and adolescents is associated with substantive psychosocial dysfunction and human suffering [1, 2]. Safe and effective treatments are needed to reduce symptomatology and improve quality of life for the…
View article: Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: Attenuated by medication
Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: Attenuated by medication Open
Previous neuroimaging studies of youth with bipolar disorder(BD) have identified abnormalities in emotion regulation circuitry. Using data from the Longitudinal Assessment of Manic Symptoms Cohort (a clinical sample recruited for behaviora…
View article: Three-Year Latent Class Trajectories of Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in a Clinical Sample Not Selected for ADHD
Three-Year Latent Class Trajectories of Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in a Clinical Sample Not Selected for ADHD Open
This study aims to examine trajectories of attention-deficit/hyperactivity disorder (ADHD) symptoms in the Longitudinal Assessment of Manic Symptoms (LAMS) sample.
View article: Emotional Face Processing in Pediatric Bipolar Disorder: Evidence for Functional Impairments in the Fusiform Gyrus
Emotional Face Processing in Pediatric Bipolar Disorder: Evidence for Functional Impairments in the Fusiform Gyrus Open
Pediatric bipolar disorder involves poor social functioning, but the neural mechanisms underlying these deficits are not well understood. Previous neuroimaging studies have found deficits in emotional face processing localized to emotional…
View article: Examining the Proposed Disruptive Mood Dysregulation Disorder Diagnosis in Children in the Longitudinal Assessment of Manic Symptoms Study
Examining the Proposed Disruptive Mood Dysregulation Disorder Diagnosis in Children in the Longitudinal Assessment of Manic Symptoms Study Open
To examine the proposed disruptive mood dysregulation disorder (DMDD) diagnosis in a child psychiatric outpatient population. Evaluation of DMDD included 4 domains: clinical phenomenology, delimitation from other diagnoses, longitudinal st…
View article: Dosing Strategies for Lithium Monotherapy in Children and Adolescents with Bipolar I Disorder
Dosing Strategies for Lithium Monotherapy in Children and Adolescents with Bipolar I Disorder Open
The primary goal of this exploratory study was to obtain data that could lead to evidence-based dosing strategies for lithium in children and adolescents suffering from bipolar I disorder.
View article: Post-Acute Effectiveness of Lithium in Pediatric Bipolar I Disorder
Post-Acute Effectiveness of Lithium in Pediatric Bipolar I Disorder Open
This study examined the long-term effectiveness of lithium for the treatment of pediatric bipolar disorder within the context of combination mood stabilizer therapy for refractory mania and pharmacological treatment of comorbid psychiatric…
View article: Clinical Characteristics of Children Receiving Antipsychotic Medication
Clinical Characteristics of Children Receiving Antipsychotic Medication Open
This study explored the demographic and diagnostic features of children who were currently receiving antipsychotics compared to children who were receiving other psychotropics in a cohort of children with and without elevated symptoms of m…
View article: Pediatric bipolar disorder and ADHD: Family history comparison in the LAMS clinical sample
Pediatric bipolar disorder and ADHD: Family history comparison in the LAMS clinical sample Open
Transgenerational association of bipolar spectrum disorder (BPSD) and attention deficit/hyperactivity disorder (ADHD) has been reported, but inconclusively.
View article: White Matter Structure in Youth With Behavioral and Emotional Dysregulation Disorders: A Probabilistic Tractographic Study
White Matter Structure in Youth With Behavioral and Emotional Dysregulation Disorders: A Probabilistic Tractographic Study Open
Psychiatric disorders in youth characterized by behavioral and emotional dysregulation are often comorbid and difficult to distinguish. An alternative approach to conceptualizing these disorders is to move toward a diagnostic system based …
View article: Parsing Dimensional vs Diagnostic Category–Related Patterns of Reward Circuitry Function in Behaviorally and Emotionally Dysregulated Youth in the Longitudinal Assessment of Manic Symptoms Study
Parsing Dimensional vs Diagnostic Category–Related Patterns of Reward Circuitry Function in Behaviorally and Emotionally Dysregulated Youth in the Longitudinal Assessment of Manic Symptoms Study Open
Pediatric disorders characterized by behavioral and emotional dysregulation pose diagnostic and treatment challenges because of high comorbidity, suggesting that they may be better conceptualized dimensionally rather than categorically. Id…
View article: Early-Onset Bipolar Spectrum Disorders: Diagnostic Issues
Early-Onset Bipolar Spectrum Disorders: Diagnostic Issues Open
Since the mid 1990s, early-onset bipolar spectrum disorders (BPSDs) have received increased attention in both the popular press and scholarly press. Rates of diagnosis of BPSD in children and adolescents have increased in inpatient, outpat…
View article: What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses?
What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses? Open
To determine the contribution of parent-reported manic symptoms, family history, stressful life events, and family environment in predicting diagnosis of bipolar spectrum disorders (BPSD) in youth presenting to an outpatient psychiatric cl…
View article: Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sample: ADHD and BPSD in LAMS children
Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sample: ADHD and BPSD in LAMS children Open
To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSD), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study.
View article: The 24-month course of manic symptoms in children
The 24-month course of manic symptoms in children Open
The Longitudinal Assessment of Manic Symptoms (LAMS) study was designed to investigate phenomenology and establish predictors of functional outcomes in children with elevated manic symptoms. The purpose of this series of analyses was to de…
View article: Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms
Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms Open
Controversy surrounds the diagnostic categorization of children with episodic moods that cause impairment, but do not meet DSM-IV criteria for bipolar I (BD-I) or bipolar II (BD-II) disorder. This study aims to characterize the degree to w…
View article: Using machine learning and surface reconstruction to accurately differentiate different trajectories of mood and energy dysregulation in youth
Using machine learning and surface reconstruction to accurately differentiate different trajectories of mood and energy dysregulation in youth Open
Difficulty regulating positive mood and energy is a feature that cuts across different pediatric psychiatric disorders. Yet, little is known regarding the neural mechanisms underlying different developmental trajectories of positive mood a…
View article: Can Emotional and Behavioral Dysregulation in Youth Be Decoded from Functional Neuroimaging?
Can Emotional and Behavioral Dysregulation in Youth Be Decoded from Functional Neuroimaging? Open
High comorbidity among pediatric disorders characterized by behavioral and emotional dysregulation poses problems for diagnosis and treatment, and suggests that these disorders may be better conceptualized as dimensions of abnormal behavio…
View article: Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders
Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders Open
Both bipolar spectrum disorders (BPSD) and attention deficit hyperactivity disorder (ADHD) present with emotion-regulation deficits, but require different clinical management. We examined how the neurobiological underpinnings of emotion re…
View article: Disruptive Mood Dysregulation Disorder and Bipolar Disorder Not Otherwise Specified: Fraternal or Identical Twins?
Disruptive Mood Dysregulation Disorder and Bipolar Disorder Not Otherwise Specified: Fraternal or Identical Twins? Open
Objective: The purpose of this study was to examine similarities and differences between disruptive mood dysregulation disorder (DMDD) and bipolar disorder not otherwise specified (BP-NOS) in baseline sociodemographic and clinical characte…
View article: Comparing the CASI-4R and the PGBI-10 M for Differentiating Bipolar Spectrum Disorders from Other Outpatient Diagnoses in Youth
Comparing the CASI-4R and the PGBI-10 M for Differentiating Bipolar Spectrum Disorders from Other Outpatient Diagnoses in Youth Open
We compared 2 rating scales with different manic symptom items on diagnostic accuracy for detecting pediatric bipolar spectrum disorder (BPSDs) in outpatient mental health clinics. Participants were 681 parents/guardians of eligible childr…