Robert A. Shapiro
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View article: Hypothalamic Estrogen Receptor α Is Essential for Female Marmoset Sexual Behavior Without Protecting From Obesity
Hypothalamic Estrogen Receptor α Is Essential for Female Marmoset Sexual Behavior Without Protecting From Obesity Open
Context Estrogen receptor α (ERα) in the ventromedial (VMN) and arcuate (ARC) nuclei of female rodent mediobasal hypothalami (MBHs) provides a crucial molecular gateway facilitating estradiol (E2) regulation of sexual behavior, reproductiv…
View article: Timely Recognition of Abusive Injuries (TRAIN): Results from a Statewide Quality Improvement Collaborative
Timely Recognition of Abusive Injuries (TRAIN): Results from a Statewide Quality Improvement Collaborative Open
Introduction: Early recognition of physical abuse is critical as children often experience recurrent abuse if their environment remains unchanged. The Timely Recognition of Abusive Injuries (TRAIN) Collaborative was a quality improvement n…
View article: OR31-05 Emergence of Ovarian Hyperandrogenism and Luteal Insufficiency Following ESR1 Knockdown in the Mediobasal Hypothalamus of Adult Female Rhesus Monkeys
OR31-05 Emergence of Ovarian Hyperandrogenism and Luteal Insufficiency Following ESR1 Knockdown in the Mediobasal Hypothalamus of Adult Female Rhesus Monkeys Open
Diminished estradiol (E2) negative feedback action by neuronal ESR1 in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) is hypothesized to cause gonadotropin-releasing hormone (GnRH) hypersecretion, and thus LH excess, contri…
View article: SUN-469 Hypothalamic ERalpha Gene Silencing Diminishes Sexual Receptivity in Female Marmoset Monkeys
SUN-469 Hypothalamic ERalpha Gene Silencing Diminishes Sexual Receptivity in Female Marmoset Monkeys Open
Estradiol (E2) has long been established as a major regulator of female sexual behavior in mammals, including primates. Estrogen receptor alpha (ERαλπηα) in the ventromedial nucleus of the hypothalamus (VMN) has been identified as the majo…
View article: Extraovarian gonadotropin negative feedback revealed by aromatase inhibition in female marmoset monkeys
Extraovarian gonadotropin negative feedback revealed by aromatase inhibition in female marmoset monkeys Open
Whereas the ovary produces the majority of estradiol (E 2 ) in mature female primates, extraovarian sources contribute to E 2 synthesis and action, including the brain E 2 -regulating hypothalamic gonadotropin-releasing hormone. In ovary-i…
View article: ERα Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy
ERα Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy Open
Male neonate brains are more susceptible to the effects of perinatal asphyxia resulting in hypoxia and ischemia (HI)-related brain injury. The relative resistance of female neonatal brains to adverse consequences of HI suggests that there …