Robert F. Asarnow
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View article: Evidence Suggesting Prolonged Neuroinflammation in a Subset of Children after Moderate/Severe TBI: A UCLA RAPBI Study
Evidence Suggesting Prolonged Neuroinflammation in a Subset of Children after Moderate/Severe TBI: A UCLA RAPBI Study Open
Traumatic brain injury (TBI) presents a public health concern as a leading cause of death and disability in children. Pediatric populations are particularly vulnerable to adverse outcomes following TBI due to periods of rapid growth, synap…
View article: The neurocognitive correlates of DTI indicators of white matter disorganization in pediatric moderate-to-severe traumatic brain injury
The neurocognitive correlates of DTI indicators of white matter disorganization in pediatric moderate-to-severe traumatic brain injury Open
Introduction Neuroimaging has expanded our understanding of pediatric brain disorders in which white matter organization and connectivity are crucial to functioning. Paralleling the known pathobiology of many neurodevelopmental disorders, …
View article: Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples
Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples Open
Objective Schizophrenia is a neurodevelopmental disorder involving clinical and genetic heterogeneity. Multiple recurrent copy number variants (CNVs) increase risk for schizophrenia spectrum disorders (SSD). However, how known risk CNVs an…
View article: Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis
Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis Open
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by ev…
View article: Metacognitive therapy for people experiencing persistent post-concussion symptoms following mild traumatic brain injury: a preliminary multiple case-series study
Metacognitive therapy for people experiencing persistent post-concussion symptoms following mild traumatic brain injury: a preliminary multiple case-series study Open
After mild traumatic brain injury (mTBI), a subgroup of individuals experiences persistent post-concussion symptoms (PPCS) that include headaches, cognitive difficulties, and fatigue. The aim of this preliminary study was to investigate po…
View article: Metacognitive Therapy for People Experiencing Persistent Post-Concussion Symptoms Following Mild Traumatic Brain Injury: A Preliminary Multiple Case-Series Study
Metacognitive Therapy for People Experiencing Persistent Post-Concussion Symptoms Following Mild Traumatic Brain Injury: A Preliminary Multiple Case-Series Study Open
After mild traumatic brain injury (mTBI), a subgroup of individuals experience persistent post-concussion symptoms (PPCS) that include headaches, cognitive difficulties, and fatigue. The aim of this preliminary study was to investigate pos…
View article: Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury
Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury Open
Importance Traumatic brain injury (TBI) is known to cause widespread neural disruption in the cerebrum. However, less is known about the association of TBI with cerebellar structure and how such changes may alter executive functioning. Obj…
View article: 68 The Impact of Pain Catastrophizing on Neuropsychological Performance in Youth with Persistent Post Concussive Symptoms
68 The Impact of Pain Catastrophizing on Neuropsychological Performance in Youth with Persistent Post Concussive Symptoms Open
Objective: Patients with persistent post-concussion symptoms (PPCS) experience prolonged recovery (e.g., headache, fatigue, or dizziness) lasting >2 months post injury. These symptoms are thought to be maintained by several biopsychosocial…
View article: Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults
Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults Open
This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data were acquired from 81 healthy adults with normal sleep (41 females, age 20.96–39.58 year…
View article: Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium
Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium Open
Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample sizes, statistical power, and representativeness of data. These efforts unveil new questions about integrating data ar…
View article: Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI
Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI Open
In survivors of moderate to severe traumatic brain injury (msTBI), affective disruptions often remain underdetected and undertreated, in part due to poor understanding of the underlying neural mechanisms. We hypothesized that limbic circui…
View article: Multimodal Analysis of Secondary Cerebellar Alterations after Pediatric Traumatic Brain Injury
Multimodal Analysis of Secondary Cerebellar Alterations after Pediatric Traumatic Brain Injury Open
While traditionally ignored as a region purely responsible for motor function, the cerebellum is increasingly being appreciated for its contributions to higher order functions through various cerebro-cerebellar networks. Traumatic brain in…
View article: Poorer Sleep Health is Associated With Altered Brain Activation During Cognitive Control Processing in Healthy Adults
Poorer Sleep Health is Associated With Altered Brain Activation During Cognitive Control Processing in Healthy Adults Open
This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data was acquired from 81 healthy adults with normal sleep (41 females, age 20.96 - 39.58 yea…
View article: Post-Concussive Orthostatic Tachycardia is Distinct from Postural Orthostatic Tachycardia Syndrome (POTS) in Children and Adolescents
Post-Concussive Orthostatic Tachycardia is Distinct from Postural Orthostatic Tachycardia Syndrome (POTS) in Children and Adolescents Open
Background: Orthostatic tachycardia (OT) affects some patients after concussion/mild traumatic brain injury (mTBI). In this study, we sought to identify the factors associated with increased risk for OT in patients with mTBI. Methods: We c…
View article: Linguistic and neurocognitive correlates of probabilistic classification learning in schizophrenia
Linguistic and neurocognitive correlates of probabilistic classification learning in schizophrenia Open
Individuals with schizophrenia demonstrate impaired implicit learning on cognitively complex tasks and preserved implicit motor learning. However, little is known about how implicit learning may be related to other linguistic and cognitive…
View article: Association of Attention-Deficit/Hyperactivity Disorder Diagnoses With Pediatric Traumatic Brain Injury
Association of Attention-Deficit/Hyperactivity Disorder Diagnoses With Pediatric Traumatic Brain Injury Open
This study noted a significant association between TBI severity and ADHD diagnosis. In children with severe but not mild and moderate TBI, there was an association with an increase in risk for ADHD. The high rate of preinjury ADHD in child…
View article: White Matter Disruption in Pediatric Traumatic Brain Injury
White Matter Disruption in Pediatric Traumatic Brain Injury Open
WM disruption after msTBI is widespread, persistent, and influenced by demographic and clinical variables. Future work will test techniques for harmonizing neurocognitive data, enabling more advanced analyses to identify symptom clusters a…
View article: Cardiorespiratory Functioning in Youth with Persistent Post-Concussion Symptoms: A Pilot Study
Cardiorespiratory Functioning in Youth with Persistent Post-Concussion Symptoms: A Pilot Study Open
Dysregulation of the autonomic nervous system (ANS) may play an important role in the development and maintenance of persistent post-concussive symptoms (PPCS). Post-injury breathing dysfunction, which is influenced by the ANS, has not bee…
View article: Poor sleep quality is associated with greater negative consequences for cognitive control function and psychological health after mild traumatic brain injury than after orthopedic injury
Poor sleep quality is associated with greater negative consequences for cognitive control function and psychological health after mild traumatic brain injury than after orthopedic injury Open
Objective: To test the hypothesis that poor sleep quality has a stronger negative effect on cognitive control function and psychological health after mild traumatic brain injury (mTBI) than after orthopedic injury. Method: Patients with mT…
View article: White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric msTBI
White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric msTBI Open
Annually, approximately 3 million children around the world experience traumatic brain injuries (TBIs), of which up to 20% are characterized as moderate to severe (msTBI) and/or have abnormal imaging findings. Affected children are vulnera…
View article: The Prevalence and Stability of Sleep-Wake Disturbance and Fatigue throughout the First Year after Mild Traumatic Brain Injury
The Prevalence and Stability of Sleep-Wake Disturbance and Fatigue throughout the First Year after Mild Traumatic Brain Injury Open
In this prospective, longitudinal study, we aimed to determine the prevalence and stability of sleep-wake disturbance (SWD) and fatigue in a large representative sample of patients (Trondheim mild traumatic brain injury [mTBI] follow-up st…
View article: Challenges and Opportunities for Neuroimaging in Young Patients with Traumatic Brain Injury: a Coordinated Effort towards Advancing Discovery from the ENIGMA Pediatric Moderate/Severe TBI Group
Challenges and Opportunities for Neuroimaging in Young Patients with Traumatic Brain Injury: a Coordinated Effort towards Advancing Discovery from the ENIGMA Pediatric Moderate/Severe TBI Group Open
Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population; however, research in this po…
View article: Baseline Cardiorespiratory Function in Youth with Persistent Post-Concussion Symptoms
Baseline Cardiorespiratory Function in Youth with Persistent Post-Concussion Symptoms Open
Objective To evaluate cardiorespiratory functions in youth with persistent post-concussion symptoms compared to controls and to examine the predictive value of relevant demographic and medical variables. Background Recent studies propose t…
View article: Functional Brain Hyperactivations Are Linked to an Electrophysiological Measure of Slow Interhemispheric Transfer Time after Pediatric Moderate/Severe Traumatic Brain Injury
Functional Brain Hyperactivations Are Linked to an Electrophysiological Measure of Slow Interhemispheric Transfer Time after Pediatric Moderate/Severe Traumatic Brain Injury Open
Increased task-related blood oxygen level dependent (BOLD) activation is commonly observed in functional magnetic resonance imaging (fMRI) studies of moderate/severe traumatic brain injury (msTBI), but the functional relevance of these hyp…
View article: Cover Image
Cover Image Open
[Image: see text] COVER ILLUSTRATION The combined predictive power of multi‐modal imaging in pediatric traumatic brain injury. Colors correspond to the amount of variance (R‐squared) in cognitive function explained by a combination of moda…