Robert B. Kirkpatrick
YOU?
Author Swipe
View article: Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in <i>KMT2A</i>- and <i>NPM1</i>-altered leukemias
Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in <i>KMT2A</i>- and <i>NPM1</i>-altered leukemias Open
The interaction between menin and histone-lysine N-methyltransferase 2A (KMT2A) is a critical dependency for KMT2A- or nucleophosmin 1 (NPM1)–altered leukemias and an emerging opportunity for therapeutic development. JNJ-75276617 (bleximen…
View article: Expansion of Proteome-wide Coxiella burnetii Comparative T-cell Epitope Prediction to Include Small Ruminant Hosts
Expansion of Proteome-wide Coxiella burnetii Comparative T-cell Epitope Prediction to Include Small Ruminant Hosts Open
Background: Coxiella burnetii is the causative agent of Q fever, a human disease that can be acquired from livestock. Diseases caused by this organism have caused great losses in livestock and human health. No vaccine is approved for use i…
View article: Patients with alcohol-related liver disease hospitalized during the COVID-19 pandemic experienced worse outcomes
Patients with alcohol-related liver disease hospitalized during the COVID-19 pandemic experienced worse outcomes Open
Patients with alcohol-related liver disease experienced worse outcomes during the pandemic.
View article: Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor Open
Human spermine oxidase (hSMOX) plays a central role in polyamine catabolism. Due to its association with several pathological processes, including inflammation and cancer, hSMOX has garnered interest as a possible therapeutic target. There…
View article: Hospital Trends of Acute Pancreatitis During the Coronavirus Disease 2019 Pandemic
Hospital Trends of Acute Pancreatitis During the Coronavirus Disease 2019 Pandemic Open
Objective The coronavirus disease 2019 pandemic led to changes in individuals' behaviors and healthcare delivery. We examined the impact of these changes on the rates and clinical course of acute pancreatitis (AP). Methods Hospitalizations…
View article: A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function
A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function Open
Introduction Delayed graft function (DGF) following renal transplantation is a manifestation of acute kidney injury (AKI) leading to poor long-term outcome. Current treatments have limited effectiveness in preventing DGF. Interleukin-18 (I…
View article: Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays
Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays Open
Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during th…
View article: A molecular signature for delayed graft function
A molecular signature for delayed graft function Open
Chronic kidney disease and associated comorbidities (diabetes, cardiovascular diseases) manifest with an accelerated ageing phenotype, leading ultimately to organ failure and renal replacement therapy. This process can be modulated by epig…
View article: Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions
Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions Open
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmi…
View article: Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress Open
Background The amino acid response ( AAR ) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broa…
View article: Measuring Economic Resilience to Natural Disasters with Big Economic Transaction Data
Measuring Economic Resilience to Natural Disasters with Big Economic Transaction Data Open
This research explores the potential to analyze bank card payments and ATM cash withdrawals in order to map and quantify how people are impacted by and recover from natural disasters. Our approach defines a disaster-affected community's ec…
View article: Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD
Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD Open
Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and VEGFD are proteolytically cleaved after cell secretion in vitro, and recent studies …