Alan R. Barker
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View article: Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors
Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors Open
View article: Determination of maximal oxygen uptake in adolescents
Determination of maximal oxygen uptake in adolescents Open
Purpose An oxygen uptake ( V̇O 2 ) plateau, despite an increased work rate, is considered the gold standard for confirming if exercise test performance reflects maximal oxygen uptake (V̇O 2max ). We investigated whether adolescents demonstra…
View article: Associations between adverse childhood experiences and vascular indicators of atherosclerosis measured in childhood and early to mid-adulthood: A systematic review
Associations between adverse childhood experiences and vascular indicators of atherosclerosis measured in childhood and early to mid-adulthood: A systematic review Open
Findings support associations between adverse childhood experiences and subclinical atherosclerotic progression, but evidence lacks quantity and quality. Prospective evidence identifying vascular changes associated with adverse childhood e…
View article: Plasma fatty acid composition predicts bone mineral accrual from childhood to adolescence: the Physical Activity and Nutrition in Children study
Plasma fatty acid composition predicts bone mineral accrual from childhood to adolescence: the Physical Activity and Nutrition in Children study Open
Little is known about the associations of plasma fatty acids (FAs) with bone mineral accrual, and the evidence is mostly based on cross-sectional data. In this observational study, we investigated for the first time the longitudinal associ…
View article: Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort
Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort Open
Objective: Insulin resistance (IR) and dysglycemia can induce cardiac remodeling in adulthood but little evidence exists with respect to cardiac remodeling in youth with and without evidence of new-onset glucose metabolic alterations. This…
View article: Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort
Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort Open
Objective: Insulin resistance (IR) and dysglycemia can induce cardiac remodeling in adulthood but little evidence exists with respect to cardiac remodeling in youth with and without evidence of new-onset glucose metabolic alterations. This…
View article: Validation of polar verity sense for heart rate monitoring during school-based high-intensity interval training in adolescents
Validation of polar verity sense for heart rate monitoring during school-based high-intensity interval training in adolescents Open
The polar verity sense (PVS) is a user-friendly heart rate monitoring tool for field-based research compared to Polar H10. However, its validity in the real world (e.g., school settings) among children and adolescents is yet to be determin…
View article: Cross-sectional associations between physical activity and sedentary time with cardiovascular health in children from the ALSPAC study using compositional data analysis
Cross-sectional associations between physical activity and sedentary time with cardiovascular health in children from the ALSPAC study using compositional data analysis Open
View article: The effect of strength training interventions on people with congenital heart disease: a systematic review
The effect of strength training interventions on people with congenital heart disease: a systematic review Open
Aim To assess the effectiveness and safety of strength training (ST) interventions in people with congenital heart disease (ConHD). Methods Participants included people of all ages diagnosed with all complexity of ConHD. Interventions incl…
View article: Peak Oxygen Consumption Scaled to Body Composition Is Associated With Mortality and Morbidity in People With a Fontan Circulation
Peak Oxygen Consumption Scaled to Body Composition Is Associated With Mortality and Morbidity in People With a Fontan Circulation Open
Background Peak oxygen consumption (peak O 2 ) is traditionally scaled by body mass, but it is most appropriately scaled by fat‐free mass. However, it is unknown whether peak O 2 scaled by fat‐free mass is associated with mor…
View article: Effectiveness of a school-based high-intensity interval training intervention in adolescents: study protocol of the PRO-HIIT cluster randomised controlled trial
Effectiveness of a school-based high-intensity interval training intervention in adolescents: study protocol of the PRO-HIIT cluster randomised controlled trial Open
Introduction High-intensity interval training (HIIT) is an effective strategy for improving a variety of health and fitness outcomes within school settings. Incorporating HIIT into existing physical activity opportunities appears practical…
View article: Middle cerebral artery blood velocity and end-tidal carbon dioxide responses to moderate intensity cycling in children, adolescents, and adults
Middle cerebral artery blood velocity and end-tidal carbon dioxide responses to moderate intensity cycling in children, adolescents, and adults Open
This is the first study to find that children have smaller increases in Δ%MCAv (∼12%) during moderate-intensity exercise compared with adolescents and adults (∼18%–20%). Furthermore, MCAv kinetics were significantly faster in children and …
View article: Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months
Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months Open
Zambon.
View article: Real-world treatment patterns, health care resource utilization, and costs in a US Medicare population with bronchiectasis
Real-world treatment patterns, health care resource utilization, and costs in a US Medicare population with bronchiectasis Open
This real-world study demonstrates the high disease burden associated with bronchiectasis and with exacerbations, highlighting the need to improve management and reduce exacerbations.
View article: Percentage Predicted Peak Oxygen Consumption in People With Fontan Circulation: A Rapid Systematic Scoping Review and Validation Study
Percentage Predicted Peak Oxygen Consumption in People With Fontan Circulation: A Rapid Systematic Scoping Review and Validation Study Open
Background Peak oxygen consumption (peak ) is routinely measured in people who have congenital heart disease and is reported as a percentage of predicted value, based upon age‐ and sex‐matched normative reference values (NRVs). T…
View article: Was it a HIIT? A process evaluation of a school-based high-intensity interval training intervention
Was it a HIIT? A process evaluation of a school-based high-intensity interval training intervention Open
View article: The Role of Diet in the Cardiovascular Health of Childhood Cancer Survivors—A Systematic Review
The Role of Diet in the Cardiovascular Health of Childhood Cancer Survivors—A Systematic Review Open
Background: Childhood cancer survivors (CCSs) face an increased risk of cardiovascular disease (CVD). This systematic review aims to provide the first synthesis of observational and interventional studies on the relationship between diet a…
View article: Co-creation of injury prevention measures for competitive adolescent distance runners: knowledge, behavior, and needs of athletes and coaches enrolled on England Athletics’ Youth Talent Programme
Co-creation of injury prevention measures for competitive adolescent distance runners: knowledge, behavior, and needs of athletes and coaches enrolled on England Athletics’ Youth Talent Programme Open
This study assessed the knowledge, behavior, and needs of competitive adolescent (16-18 years) distance runners and distance running coaches enrolled as part of England Athletics' Youth Talent Programme in relation to the prevention of run…
View article: Adapting, restarting, and terminating a randomised control trial for people with cystic fibrosis: Reflections on the impact of the COVID-19 pandemic upon research in a clinical population
Adapting, restarting, and terminating a randomised control trial for people with cystic fibrosis: Reflections on the impact of the COVID-19 pandemic upon research in a clinical population Open
View article: Accelerometer‐based sedentary time, light physical activity, and <scp>moderate‐to‐vigorous</scp> physical activity from childhood with arterial stiffness and carotid <scp>IMT</scp> progression: A <scp>13‐year</scp> longitudinal study of 1339 children
Accelerometer‐based sedentary time, light physical activity, and <span>moderate‐to‐vigorous</span> physical activity from childhood with arterial stiffness and carotid <span>IMT</span> progression: A <span>13‐year</span> longitudinal study of 1339 children Open
Aims We examined the longitudinal associations of sedentary time (ST), light physical activity (LPA), and moderate‐to‐vigorous PA (MVPA) from childhood with carotid‐femoral pulse wave velocity (cfPWV), a measure of arterial stiffness and c…
View article: Physical activity, physical fitness and self-rated health: cross-sectional and longitudinal associations in adolescents
Physical activity, physical fitness and self-rated health: cross-sectional and longitudinal associations in adolescents Open
Objectives To evaluate the independent associations of physical activity and physical fitness with self-rated health in adolescents. Methods Data from a 2-year observational study (2013–2015) were used (n=256, 58% girls, 13.7±0.3 years at …
View article: Process evaluation of school-based high-intensity interval training interventions for children and adolescents: a systematic review and meta-analysis of randomized controlled trials
Process evaluation of school-based high-intensity interval training interventions for children and adolescents: a systematic review and meta-analysis of randomized controlled trials Open
View article: Cross-sectional and longitudinal associations between the 24-hour movement behaviours, including muscle and bone strengthening activity, with bone and lean mass from childhood to adolescence
Cross-sectional and longitudinal associations between the 24-hour movement behaviours, including muscle and bone strengthening activity, with bone and lean mass from childhood to adolescence Open
View article: Which indices of cardiorespiratory fitness are more strongly associated with brain health in children with overweight/obesity?
Which indices of cardiorespiratory fitness are more strongly associated with brain health in children with overweight/obesity? Open
Purpose To compare the strength of associations between different indices of cardiorespiratory fitness (CRF) and brain health outcomes in children with overweight/obesity. Methods Participants were 100 children aged 8–11 years. CRF was ass…
View article: Cross-sectional and longitudinal associations of total dairy intake and dairy subtypes with body composition in children
Cross-sectional and longitudinal associations of total dairy intake and dairy subtypes with body composition in children Open
View article: Cumulative accelerometer-based light physical activity from childhood through young adulthood with arterial stiffness and carotid intima-media thickness progression: a 13-year longitudinal study
Cumulative accelerometer-based light physical activity from childhood through young adulthood with arterial stiffness and carotid intima-media thickness progression: a 13-year longitudinal study Open
Background Arterial stiffness is a novel risk factor for elevated blood pressure and hypertension in adolescents and young adults. Arterial stiffness and carotid intima-media thickness (cIMT) progression have been associated with cardiovas…
View article: Cumulative accelerometer-based sedentary time from childhood through young adulthood with increased arterial stiffness and carotid intima-media thickness in youth: a 13-year longitudinal study
Cumulative accelerometer-based sedentary time from childhood through young adulthood with increased arterial stiffness and carotid intima-media thickness in youth: a 13-year longitudinal study Open
Background Arterial stiffness and carotid intima-media thickness (cIMT) progression have been associated with cardiovascular morbidity and mortality in adulthood. Arterial stiffness is a strong risk factor for elevated blood pressure and h…
View article: A Machine Learning Approach for Physical Activity Recognition in Cystic Fibrosis
A Machine Learning Approach for Physical Activity Recognition in Cystic Fibrosis Open
This study aimed to develop and validate machine learning models to predict intensities in children and adolescents with cystic fibrosis (CF) across different accelerometry brands and placements. Thirty-five children and adolescents with C…
View article: Parental recommendations and exercise attitudes in congenital hearts
Parental recommendations and exercise attitudes in congenital hearts Open
Background: Children and young people with CHD benefit from regular physical activity. Parents are reported as facilitators and barriers to their children’s physical activity. The aim of this study was to explore parental factors, child fa…
View article: Making a HIIT: Methods for quantifying intensity in high-intensity interval training in schools and validity of session rating of perceived exertion
Making a HIIT: Methods for quantifying intensity in high-intensity interval training in schools and validity of session rating of perceived exertion Open
Using the data from Making a HIIT, this paper aimed to: 1) investigate the different heart rate (HR) quantification methods reported in school-based high-intensity interval training (HIIT) studies; and 2) assess the criterion validi…