Robert Barket
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View article: Risk stratification for disease reactivation after therapy de-escalation/discontinuation in relapsing multiple sclerosis by the VIAADISC score
Risk stratification for disease reactivation after therapy de-escalation/discontinuation in relapsing multiple sclerosis by the VIAADISC score Open
Risk of disease reactivation after discontinuation from DMF/TERI can be stratified with the VIAADISC score and appears to be safe above age 45-55 and with long-lasting stability. However, risk after de-escalation from NTZ/FTY is too high t…
View article: Kappa free light chain index predicts long-term disease activity and disability accrual in multiple sclerosis
Kappa free light chain index predicts long-term disease activity and disability accrual in multiple sclerosis Open
Background: The prognostic value of κ-free light chain (κ-FLC) index over the long term is unknown. Objectives: The objective of the study was to determine whether κ-FLC index determined at disease onset predicts relapse activity and disab…
View article: Effect of long-term frozen storage on stability of kappa free light chain index
Effect of long-term frozen storage on stability of kappa free light chain index Open
Objectives To investigate whether frozen storage duration influences κ-FLC index. Methods CSF and serum samples of patients with multiple sclerosis collected for routine diagnostic purposes had been stored at −20 °C. κ-FLC and albumin conc…
View article: Short‐Term Risk Factors for Bone Loss in Multiple Sclerosis: A Prospective Study and Literature Review
Short‐Term Risk Factors for Bone Loss in Multiple Sclerosis: A Prospective Study and Literature Review Open
Background Reduced bone mass and increased osteoporosis risk are common in people with multiple sclerosis (pwMS). The aim of the study was to identify risk factors for short‐term bone loss in MS. Methods This prospective study included 139…
View article: Impact of renal function impairment on kappa free light chain index
Impact of renal function impairment on kappa free light chain index Open
Objectives To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. Methods Patients with non-inflammatory neurological diseases were eligible. κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin …
View article: Face exploration, emotion recognition, and emotional enhancement of memory in relapsing-remitting multiple sclerosis
Face exploration, emotion recognition, and emotional enhancement of memory in relapsing-remitting multiple sclerosis Open
Background Recognizing familiar faces and identifying emotions through facial expressions are essential for social functioning. This study aimed to examine whether people with relapsing-remitting multiple sclerosis (PwMS) differ from healt…
View article: Reactive Pleocytosis After Repeated Lumbar Puncture—Implications for Clinical Practice
Reactive Pleocytosis After Repeated Lumbar Puncture—Implications for Clinical Practice Open
Introduction Lumbar puncture (LP) is a routine clinical procedure and, in some cases, is repeatedly performed for diagnostic or therapeutic reasons. The impact of repeated LP on cerebrospinal fluid (CSF) findings is not clear. Objective To…
View article: Olfactory threshold as a biomarker of long-term relapse activity in multiple sclerosis
Olfactory threshold as a biomarker of long-term relapse activity in multiple sclerosis Open
OT is a potential surrogate marker for long-term inflammatory disease activity and DMT failure in MS.
View article: Odour discrimination and identification as a biomarker of long-term disability worsening in multiple sclerosis
Odour discrimination and identification as a biomarker of long-term disability worsening in multiple sclerosis Open
Background: Odour discrimination and identification (DI) are markers associated with disability worsening and neuroaxonal damage in multiple sclerosis (MS). Objective: The main objective of this research is to investigate whether longitudi…
View article: Immune profiling in multiple sclerosis: a single-center study of 65 cytokines, chemokines, and related molecules in cerebrospinal fluid and serum
Immune profiling in multiple sclerosis: a single-center study of 65 cytokines, chemokines, and related molecules in cerebrospinal fluid and serum Open
Introduction The understanding of the pathophysiology of multiple sclerosis (MS) has evolved alongside the characterization of cytokines and chemokines in cerebrospinal fluid (CSF) and serum. However, the complex interplay of pro- and anti…
View article: Screening for osteoporosis in people with MS: A new risk score
Screening for osteoporosis in people with MS: A new risk score Open
This risk score enables individual screening recommendation for pwMS and, subsequently, early prevention of osteoporosis which probably should result in reduction of fractures and morbidity.
View article: Immunization status in patients with multiple sclerosis: A cross‐sectional, monocenter study in Austria
Immunization status in patients with multiple sclerosis: A cross‐sectional, monocenter study in Austria Open
Background and purpose Patients with multiple sclerosis (MS) under certain disease‐modifying therapies (DMT) show a higher risk of infection and a lower immune response to vaccination. Hence, assessing immunization status prior to DMT star…
View article: Sexual dysfunction in female and male people with multiple sclerosis: disability, depression and hormonal status matter
Sexual dysfunction in female and male people with multiple sclerosis: disability, depression and hormonal status matter Open
Background and purpose Sexual dysfunction (SD) in people with multiple sclerosis (pwMS) is common and an often underestimated issue in the care of pwMS. The objective of the study was to evaluate risk factors for SD in pwMS, correlate its …
View article: Prevalence and Predictive Value of Anemia and Dysregulated Iron Homeostasis in Patients with COVID-19 Infection
Prevalence and Predictive Value of Anemia and Dysregulated Iron Homeostasis in Patients with COVID-19 Infection Open
Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients present with systemic inflammation, we studied the prevalence and predictive value of anemia of inflammation (AI) or functional iron deficiency (FID)…