Robert Bém
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View article: Charcot foot disease: A new approach
Charcot foot disease: A new approach Open
Charcot neuropathic osteoarthropathy (CNO) is a condition that develops in the presence of neuropathy, most commonly diabetes-related neuropathy. Owing to the neuropathy, microtrauma to the bones occur without the individual feeling them. …
View article: Novel in vivo porcine models of chronic ischemic tissue
Novel in vivo porcine models of chronic ischemic tissue Open
There is a lack of reliable in vivo models that replicate limb-threatening ischemia in humans. To fill this gap, we developed and validated two novel porcine ischemic models: ischemic limb and dorsal flap models, both with and without stre…
View article: The Role of Personality in Shaping Diabetes Management Strategies and Technology Adoption
The Role of Personality in Shaping Diabetes Management Strategies and Technology Adoption Open
As a chronic metabolic disease, diabetes mellitus necessitates ongoing self-management to control blood sugar levels and avoid complications. Although diabetes management relies heavily on technologies like insulin pumps and continuous glu…
View article: Demographic and Clinical Characteristics of Patients With Charcot Neuro‐Osteoarthropathy in People With Diabetes Mellitus in Six Countries: A Multicenter Observational Study From 1996 to 2022
Demographic and Clinical Characteristics of Patients With Charcot Neuro‐Osteoarthropathy in People With Diabetes Mellitus in Six Countries: A Multicenter Observational Study From 1996 to 2022 Open
Aim: To describe the demographic and clinical characteristics of patients with Charcot neuro‐osteoarthropathy (CNO) and to examine for differences between participants with Type 1 diabetes mellitus (DM) (T1DM) and Type 2 diabetes mellitus …
View article: 1680-P: Glucose Control and Prevalence of Diabetic Complications in Overweight and Obese Patients with Type 1 Diabetes Mellitus
1680-P: Glucose Control and Prevalence of Diabetic Complications in Overweight and Obese Patients with Type 1 Diabetes Mellitus Open
Introduction & Objective: Obesity is becoming a frequent comorbidity not only in patients with type 2 but also with type 1 diabetes mellitus (T1D). The aim of this study was to compare glucose control and prevalence of diabetes-associated …
View article: Animal experimental models of ischemic limbs – A systematic review
Animal experimental models of ischemic limbs – A systematic review Open
This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute…
View article: Chronic Venous Disease and Its Intersections With Diabetes Mellitus
Chronic Venous Disease and Its Intersections With Diabetes Mellitus Open
Chronic venous disease (CVD) is a vascular disorder in which blood return is severely compromised and CVD is usually characterized by venous hypertension. Along with obesity and diabetes mellitus, CVD is one of the most common civilization…
View article: Guidelines on the diagnosis and treatment of active Charcot neuro‐osteoarthropathy in persons with diabetes mellitus (IWGDF 2023)
Guidelines on the diagnosis and treatment of active Charcot neuro‐osteoarthropathy in persons with diabetes mellitus (IWGDF 2023) Open
The International Working Group on the Diabetic Foot (IWGDF) has published evidence‐based guidelines on the prevention and management of diabetic foot disease since 1999. This is the first guideline on the diagnosis and treatment of active…
View article: Diagnosis and treatment of active charcot neuro‐osteoarthropathy in persons with diabetes mellitus: A systematic review
Diagnosis and treatment of active charcot neuro‐osteoarthropathy in persons with diabetes mellitus: A systematic review Open
Background There are uncertainties regarding the diagnostic criteria, optimal treatment methods, interventions, monitoring and determination of remission of Charcot neuro‐osteoarthropathy (CNO) of the foot and ankle in people with diabetes…
View article: Comparison of the impact of autologous cell therapy and conservative standard treatment on tissue oxygen supply and course of the diabetic foot in patients with chronic limb-threatening ischemia: A randomized controlled trial
Comparison of the impact of autologous cell therapy and conservative standard treatment on tissue oxygen supply and course of the diabetic foot in patients with chronic limb-threatening ischemia: A randomized controlled trial Open
Background Autologous cell therapy (ACT) is a new treatment method for patients with diabetes and no-option chronic limb-threatening ischemia (NO-CLTI). We aimed to assess the impact of ACT on NO-CLTI in comparison with standard treatment …
View article: Comparison of the impact of autologous cell therapy and conservative standard treatment on tissue oxygen supply and course of the diabetic foot in patients with chronic limbthreatening ischemia: A randomized controlled trial
Comparison of the impact of autologous cell therapy and conservative standard treatment on tissue oxygen supply and course of the diabetic foot in patients with chronic limbthreatening ischemia: A randomized controlled trial Open
Chronic limb-threatening ischemia (CLTI) is a new term used for the end stage of peripheral arterial disease instead of the older term “critical limb ischemia”. Management of CLTI has been recently summarized in a guideline document, ‘Glob…
View article: Effects of a 12-Week Interventional Exercise Programme on Muscle Strength, Mobility and Fitness in Patients With Diabetic Foot in Remission: Results From BIONEDIAN Randomised Controlled Trial
Effects of a 12-Week Interventional Exercise Programme on Muscle Strength, Mobility and Fitness in Patients With Diabetic Foot in Remission: Results From BIONEDIAN Randomised Controlled Trial Open
Objectives Diabetic foot syndrome (DFS) is a serious late diabetic complication characterised by limited joint mobility and other biomechanical and muscle abnormalities. Aim To evaluate the effect of an interventional exercise programme on…
View article: Factors Influencing the Risk of Major Amputation in Patients with Diabetic Foot Ulcers Treated by Autologous Cell Therapy
Factors Influencing the Risk of Major Amputation in Patients with Diabetic Foot Ulcers Treated by Autologous Cell Therapy Open
Introduction. Autologous cell therapy (ACT) is one of the last options for limb salvage in patients with chronic limb-threatening ischemia (CLTI) and diabetic foot ulcers (DFU). However, some patients may still undergo a major amputation e…
View article: Stimulation TcPO2 Testing Improves Diagnosis of Peripheral Arterial Disease in Patients With Diabetic Foot
Stimulation TcPO2 Testing Improves Diagnosis of Peripheral Arterial Disease in Patients With Diabetic Foot Open
Background All diagnostic procedures of peripheral arterial disease (PAD) in diabetic foot (DF) are complicated due to diabetes mellitus and its late complications. The aim of our study is to enhance diagnosis of PAD using a novel transcut…
View article: The Superiority of Removable Contact Splints in the Healing of Diabetic Foot during Postoperative Care
The Superiority of Removable Contact Splints in the Healing of Diabetic Foot during Postoperative Care Open
Objective . Off-loading is one of the crucial components of diabetic foot (DF) therapy. However, there remains a paucity of studies on the most suitable off-loading for DF patients under postoperative care. The aim of our study was to eval…
View article: Clinical and (31)P magnetic resonance spectroscopy characterization of patients with critical limb ischemia before and after autologous cell therapy
Clinical and (31)P magnetic resonance spectroscopy characterization of patients with critical limb ischemia before and after autologous cell therapy Open
Autologous cell therapy (ACT) is a new treatment method for diabetic patients with critical limb ischemia (CLI) not eligible for standard revascularization. After intramuscular injection of bone marrow-derived mononuclear cells local arter…
View article: Perfusion Scintigraphy in the Assessment of Autologous Cell Therapy in Diabetic Patients With Critical Limb Ischemia
Perfusion Scintigraphy in the Assessment of Autologous Cell Therapy in Diabetic Patients With Critical Limb Ischemia Open
Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile (99mTc-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whe…
View article: Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty
Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty Open
The aim of this study was to compare the serum levels of the anti-angiogenic factor endostatin (S-endostatin) as a potential marker of vasculogenesis after autologous cell therapy (ACT) versus percutaneous transluminal angioplasty (PTA) in…
View article: An Alteration of Lymphocytes Subpopulations and Immunoglobulins Levels in Patients with Diabetic Foot Ulcers Infected Particularly by Resistant Pathogens
An Alteration of Lymphocytes Subpopulations and Immunoglobulins Levels in Patients with Diabetic Foot Ulcers Infected Particularly by Resistant Pathogens Open
The aim of our study was to analyse immune abnormalities in patients with chronic infected diabetic foot ulcers (DFUs) especially those infected by resistant microorganisms. Methods . 68 patients treated in our foot clinic for infected chr…