Robert Benisch
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View article: Structural and biochemical characterization of an encapsulin‐associated rhodanese from <i>Acinetobacter baumannii</i>
Structural and biochemical characterization of an encapsulin‐associated rhodanese from <i>Acinetobacter baumannii</i> Open
Rhodanese‐like domains (RLDs) represent a widespread protein family canonically involved in sulfur transfer reactions between diverse donor and acceptor molecules. RLDs mediate these transsulfuration reactions via a transient persulfide in…
View article: Targeted protein degradation systems to enhance Wnt signaling
Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an a…
View article: Author response: Targeted protein degradation systems to enhance Wnt signaling
Author response: Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an a…
View article: Targeted protein degradation systems to enhance Wnt signaling
Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an a…
View article: Structural and biochemical characterization of an encapsulin-associated rhodanese from<i>Acinetobacter baumannii</i>
Structural and biochemical characterization of an encapsulin-associated rhodanese from<i>Acinetobacter baumannii</i> Open
Rhodanese-like domains (RLDs) represent a widespread protein family canonically involved in sulfur transfer reactions between diverse donor and acceptor molecules. RLDs mediate these transsulfuration reactions via a transient persulfide in…
View article: Targeted protein degradation systems to enhance Wnt signaling
Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an a…
View article: Reviewer #1 (Public Review): Targeted protein degradation systems to enhance Wnt signaling
Reviewer #1 (Public Review): Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. Human hepatic lectin, asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti…
View article: Targeted protein degradation systems to enhance Wnt signaling
Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. Human hepatic lectin, asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti…
View article: Reviewer #2 (Public Review): Targeted protein degradation systems to enhance Wnt signaling
Reviewer #2 (Public Review): Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. Human hepatic lectin, asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti…
View article: A widespread bacterial protein compartment sequesters and stores elemental sulfur
A widespread bacterial protein compartment sequesters and stores elemental sulfur Open
Subcellular compartments often serve to store nutrients or sequester labile or toxic compounds. As bacteria mostly do not possess membrane-bound organelles, they often have to rely on protein-based compartments. Encapsulins are one of the …
View article: Targeted protein degradation systems to enhance Wnt signaling
Targeted protein degradation systems to enhance Wnt signaling Open
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an a…
View article: A widespread proteinaceous sulfur storage compartment in bacteria
A widespread proteinaceous sulfur storage compartment in bacteria Open
Intracellular compartmentalization is essential for all cells and enables the regulation and optimization of metabolism 1 . One of the main functions of subcellular compartments is the storage of nutrients 2–4 . As bacteria do generally no…
View article: Encapsulin cargo loading: progress and potential
Encapsulin cargo loading: progress and potential Open
Encapsulins are protein compartments that encapsulate cargo proteins via specific peptide targeting motifs. Fusion of these motifs to non-native cargo proteins allows the facile engineering of rationally designed nano-compartmentalization …