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View article: Correction: Chen et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211
Correction: Chen et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211 Open
In the original publication [...]
View article: Impact of Metastatic Microenvironment on Physiology and Metabolism of Small Cell Neuroendocrine Prostate Cancer Patient-Derived Xenografts
Impact of Metastatic Microenvironment on Physiology and Metabolism of Small Cell Neuroendocrine Prostate Cancer Patient-Derived Xenografts Open
Background: Potent androgen receptor pathway inhibitors induce small cell neuroendocrine prostate cancer (SCNC), a highly aggressive subtype of metastatic androgen deprivation-resistant prostate cancer (ARPC) with limited treatment options…
View article: Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes
Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes Open
Background: Most of the existing hyperpolarized (HP) 13C MRI analyses use univariate rate maps of pyruvate-to-lactate conversion (kPL), and radiomic-style multiparametric models extracting complex, higher-order features remain unexplored. …
View article: Consensus recommendations for hyperpolarized [1‐ <scp> <sup>13</sup> C </scp> ]pyruvate <scp>MRI</scp> multi‐center human studies
Consensus recommendations for hyperpolarized [1‐ <span> <sup>13</sup> C </span> ]pyruvate <span>MRI</span> multi‐center human studies Open
MRI of hyperpolarized (HP) [1‐ 13 C]pyruvate allows in vivo assessment of metabolism and has translated into human studies across diseases at 15 centers worldwide. To determine consensus on best practice for multi‐center studies for develo…
View article: Translation of hyperpolarized [13C,15N2]urea MRI for novel human brain perfusion studies
Translation of hyperpolarized [13C,15N2]urea MRI for novel human brain perfusion studies Open
This study developed a new approach to produce sterile, hyperpolarized [ 13 C, 15 N 2 ]urea as a novel molecular imaging probe and applied it for first-ever healthy brain volunteer studies. Hyperpolarized [ 13 C, 15 N 2 ]urea, as a small, …
View article: Clinical Translation of Hyperpolarized <sup>13</sup> C Metabolic Probes for Glioma Imaging
Clinical Translation of Hyperpolarized <sup>13</sup> C Metabolic Probes for Glioma Imaging Open
Hyperpolarized carbon-13 (HP-13C) MRI enables the real-time measurement of dynamic metabolism by utilizing molecular probes whose magnetization has been transiently enhanced via dynamic nuclear polarization of 13C labels. Based on preclini…
View article: A data‐driven approach for improved quantification of in vivo metabolic conversion rates of hyperpolarized [1‐ <scp> <sup>13</sup> C </scp> ]pyruvate
A data‐driven approach for improved quantification of in vivo metabolic conversion rates of hyperpolarized [1‐ <span> <sup>13</sup> C </span> ]pyruvate Open
Purpose Accurate quantification of metabolism in hyperpolarized (HP) 13 C MRI is essential for clinical applications. However, kinetic model parameters are often confounded by uncertainties in radiofrequency flip angles and other model par…
View article: Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer
Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer Open
Background: Although multiparametric (mp) 1H magnetic resonance imaging (MRI) is increasingly used to detect and localize prostate cancer (PC), its correlation with tumor grade is limited. Hyperpolarized (HP) carbon-13 (13C) MR is an emerg…
View article: Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors
Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors Open
Tumor acidosis is one of the hallmarks indicating the initiation and progression of various cancers. Here, we present a protocol for preparing a hyperpolarized (HP) 13C-bicarbonate tissue pH MRI imaging contrast agent to detect aggressive …
View article: Current methods for hyperpolarized [<scp>1‐<sup>13</sup>C</scp>]pyruvate <scp>MRI</scp> human studies
Current methods for hyperpolarized [<span>1‐<sup>13</sup>C</span>]pyruvate <span>MRI</span> human studies Open
MRI with hyperpolarized (HP) 13 C agents, also known as HP 13 C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies…
View article: Distinguishing metabolic signals of liver tumors from surrounding liver cells using hyperpolarized <scp><sup>13</sup>C MRI</scp> and gadoxetate
Distinguishing metabolic signals of liver tumors from surrounding liver cells using hyperpolarized <span><sup>13</sup>C MRI</span> and gadoxetate Open
Purpose To use the hepatocyte‐specific gadolinium‐based contrast agent gadoxetate combined with hyperpolarized (HP) [1‐ 13 C]pyruvate MRI to selectively suppress metabolic signals from normal hepatocytes while preserving the signals arisin…
View article: Advanced Hyperpolarized 13C Metabolic Imaging Protocol for Patients with Gliomas: A Comprehensive Multimodal MRI Approach
Advanced Hyperpolarized 13C Metabolic Imaging Protocol for Patients with Gliomas: A Comprehensive Multimodal MRI Approach Open
This study aimed to implement a multimodal 1H/HP-13C imaging protocol to augment the serial monitoring of patients with glioma, while simultaneously pursuing methods for improving the robustness of HP-13C metabolic data. A total of 100 1H/…
View article: Hyperpolarized <scp><sup>13</sup>C</scp> metabolic imaging of the human abdomen with spatiotemporal denoising
Hyperpolarized <span><sup>13</sup>C</span> metabolic imaging of the human abdomen with spatiotemporal denoising Open
Purpose Improving the quality and maintaining the fidelity of large coverage abdominal hyperpolarized (HP) 13 C MRI studies with a patch based global–local higher‐order singular value decomposition (GL‐HOVSD) spatiotemporal denoising appro…
View article: Hyperpolarized [<scp>1‐<sup>13</sup>C</scp>] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline‐deficient diet rat model of fatty liver disease
Hyperpolarized [<span>1‐<sup>13</sup>C</span>] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline‐deficient diet rat model of fatty liver disease Open
Purpose Nonalcoholic fatty liver disease is an important cause of chronic liver disease. There are limited methods for monitoring metabolic changes during progression to steatohepatitis. Hyperpolarized 13 C MRSI (HP 13 C MRSI) was used to …
View article: Dynamic T2* relaxometry of hyperpolarized [<scp>1‐<sup>13</sup>C</scp>]pyruvate <scp>MRI</scp> in the human brain and kidneys
Dynamic T2* relaxometry of hyperpolarized [<span>1‐<sup>13</sup>C</span>]pyruvate <span>MRI</span> in the human brain and kidneys Open
Purpose This study aimed to quantify for hyperpolarized [1‐ 13 C]pyruvate and metabolites in the healthy human brain and renal cell carcinoma (RCC) patients at 3 T. Methods Dynamic values were measured with a metabolite‐specific multi‐echo…
View article: Current Methods for Hyperpolarized [1-<sup>13</sup>C]pyruvate MRI Human Studies.
Current Methods for Hyperpolarized [1-<sup>13</sup>C]pyruvate MRI Human Studies. Open
MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies d…
View article: Clinically Translatable Hyperpolarized <sup>13</sup>C Bicarbonate pH Imaging Method for Use in Prostate Cancer
Clinically Translatable Hyperpolarized <sup>13</sup>C Bicarbonate pH Imaging Method for Use in Prostate Cancer Open
Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment with pH 6.5-7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell proliferation. In preclinical prostate cancer models, disease…
View article: Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-<sup>13</sup>C]Pyruvate MR Spectroscopy
Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-<sup>13</sup>C]Pyruvate MR Spectroscopy Open
Summary Introduction The normal heart has remarkable metabolic flexibility that permits rapid switching between mitochondrial glucose oxidation and fatty acid (FA) oxidation to generate ATP. Loss of metabolic flexibility has been implicate…
View article: Regional quantification of cardiac metabolism with hyperpolarized [1 -<sup>13</sup>C]-pyruvate MRI evaluated in an oral glucose challenge
Regional quantification of cardiac metabolism with hyperpolarized [1 -<sup>13</sup>C]-pyruvate MRI evaluated in an oral glucose challenge Open
Background The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) 13 C-pyruvate MRI is a promising new tool for…
View article: Investigating cerebral perfusion with high resolution hyperpolarized [1‐<sup>13</sup>C]pyruvate MRI
Investigating cerebral perfusion with high resolution hyperpolarized [1‐<sup>13</sup>C]pyruvate MRI Open
Purpose To investigate high‐resolution hyperpolarized (HP) 13 C pyruvate MRI for measuring cerebral perfusion in the human brain. Methods HP [1‐ 13 C]pyruvate MRI was acquired in five healthy volunteers with a multi‐resolution EPI sequence…
View article: Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage
Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage Open
Hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) was applied for the first time to image and quantify the uptake and metabolism of [2-13C]pyruvate in the human brain to provide new metabolic information on cerebral energy metabolis…
View article: Supplementary Materials and Methods from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion
Supplementary Materials and Methods from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion Open
Supplementary Materials and Methods that includes "Hyperpolarization of 13C-labelled compounds", "Histochemical analysis", "mRNA expression and enzyme activity analyses", "Compressed Sensing Reconstruction and Spectroscopic Peak Estimation…
View article: Data from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion
Data from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion Open
New magnetic resonance (MR) molecular imaging techniques offer the potential for noninvasive, simultaneous quantification of metabolic and perfusion parameters in tumors. This study applied a three-dimensional dynamic dual-agent hyperpolar…
View article: Data from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion
Data from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion Open
New magnetic resonance (MR) molecular imaging techniques offer the potential for noninvasive, simultaneous quantification of metabolic and perfusion parameters in tumors. This study applied a three-dimensional dynamic dual-agent hyperpolar…
View article: Supplementary Materials and Methods from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion
Supplementary Materials and Methods from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion Open
Supplementary Materials and Methods that includes "Hyperpolarization of 13C-labelled compounds", "Histochemical analysis", "mRNA expression and enzyme activity analyses", "Compressed Sensing Reconstruction and Spectroscopic Peak Estimation…
View article: Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge
Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge Open
We demonstrate first-in-human regional quantifications of cardiac metabolism by HP 13C-pyruvate MRI that aims to reflect LDH and PDH activity.
View article: Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma
Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma Open
Patient-derived xenografts (PDX) are high-fidelity cancer models typically credentialled by genomics, transcriptomics and proteomics. Characterization of metabolic reprogramming, a hallmark of cancer, is less frequent. Dysregulated metabol…