Robert Bronstein
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View article: Poster 133: Patients With Major Depressive Disorder and Undiagnosed Depression Are at Risk for Inferior Outcomes After MPFL Reconstruction
Poster 133: Patients With Major Depressive Disorder and Undiagnosed Depression Are at Risk for Inferior Outcomes After MPFL Reconstruction Open
Objectives: Medial patellofemoral ligament (MPFL) reconstruction is commonly performed in patients with recurrent patellar dislocations and associated instability. However, though general outcomes and when to perform concomitant surgical p…
View article: Induction of plasmalemmal vesicle-associated protein exacerbates glomerular endothelial injury in thrombotic microangiopathy
Induction of plasmalemmal vesicle-associated protein exacerbates glomerular endothelial injury in thrombotic microangiopathy Open
This study investigated the mechanism(s) underlying glomerular endothelial cell (GEnC) injury in thrombotic microangiopathy (TMA). We identified plasmalemmal vesicle-associated protein (PLVAP) as specifically upregulated in injured GEnCs i…
View article: A Small Molecule Agonist of Krüppel-Like Factor 15 in Proteinuric Kidney Disease
A Small Molecule Agonist of Krüppel-Like Factor 15 in Proteinuric Kidney Disease Open
Key Points A human podocyte-based high-throughput screen identified a novel agonist of Krüppel-like factor 15 (BT503), independent of glucocorticoid signaling. BT503 demonstrated renoprotective effects in three independent proteinuric kidn…
View article: Arthroscopic subacromial decompression improved outcomes in situationally depressed patients compared to clinically depressed or nondepressed patients
Arthroscopic subacromial decompression improved outcomes in situationally depressed patients compared to clinically depressed or nondepressed patients Open
Patients improved after undergoing SAD regardless of underlying Dep or depressive symptoms. Depressed patients exhibited greater change in PROMIS scores compared to nondepressed patients. Smoking remains a risk factor for postoperative out…
View article: Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers
Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers Open
High-multiplex detection of protein biomarkers across tissue regions has been an attractive spatial biology approach due to significant advantages over traditional immunohistochemistry (IHC) methods. Different from most methods, spatial mu…
View article: Impact of Sports Participation on Achievement of Clinically Relevant Outcomes 2 Years After ACL Reconstruction
Impact of Sports Participation on Achievement of Clinically Relevant Outcomes 2 Years After ACL Reconstruction Open
Background: Clinically relevant threshold values associated with patient-reported outcome measures after orthopaedic procedures such as anterior cruciate ligament reconstruction (ACLR) are important for relating these scores to meaningful …
View article: Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease
Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease Open
Podocytes and parietal epithelial cells (PECs) are among the few principal cell types within the kidney glomerulus, the former serving as a crucial constituent of the kidney filtration barrier and the latter representing a supporting epith…
View article: Gene regulation by gonadal hormone receptors underlies brain sex differences
Gene regulation by gonadal hormone receptors underlies brain sex differences Open
Oestradiol establishes neural sex differences in many vertebrates 1–3 and modulates mood, behaviour and energy balance in adulthood 4–8 . In the canonical pathway, oestradiol exerts its effects through the transcription factor oestrogen re…
View article: Recent Advances in Kidney Bioengineering
Recent Advances in Kidney Bioengineering Open
Kidney disease is an epidemic that affects more than 600 million people worldwide. The socioeconomic impacts of the disease disproportionately affect Hispanic and non-Hispanic Black Americans, making the disease an issue of social inequali…
View article: Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney
Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney Open
Integrative omics identifies mediators between podocytes and parietal epithelial cells in proliferative glomerulopathies.
View article: Regulation of neural gene expression by estrogen receptor alpha
Regulation of neural gene expression by estrogen receptor alpha Open
The transcription factor estrogen receptor α (ERα) is a principal regulator of sex differences in the vertebrate brain and can modulate mood, behavior, and energy balance in females and males. However, the genes regulated by ERα in the bra…
View article: The Effect of Depression on Patient Reported Outcomes Measurement and Information System Computer Adaptive Test (PROMIS-CAT) scores and Return-to-Sport following ACL Reconstruction
The Effect of Depression on Patient Reported Outcomes Measurement and Information System Computer Adaptive Test (PROMIS-CAT) scores and Return-to-Sport following ACL Reconstruction Open
Objectives: Depression has been shown to have a negative effect on many orthopaedic surgical outcomes. The purpose of this study was to determine whether preoperative clinical diagnosis of depression and/or PROMIS (Patient-Reported Outcome…
View article: Preoperative PROMIS Scores Predict Postoperative Outcomes After Primary ACL Reconstruction
Preoperative PROMIS Scores Predict Postoperative Outcomes After Primary ACL Reconstruction Open
Background: PROMIS (Patient-Reported Outcomes Measurement Information System) scores in patients undergoing anterior cruciate ligament (ACL) reconstruction have not been fully described in the literature to date. The ability of preoperativ…
View article: The use of PROMIS CAT Physical Function Pre-surgical Scores to Predict Recovery and Establish Pre-surgical Cut-off Values
The use of PROMIS CAT Physical Function Pre-surgical Scores to Predict Recovery and Establish Pre-surgical Cut-off Values Open
Objectives: There is a lack of standardized outcome measures or methods to study the effects of treatment and to effectively monitor and document patient outcomes. We have used Patient Reported Outcome Measurement Information System (PROMI…
View article: Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2
Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2 Open
Mouse cortical development relies heavily on a delicate balance between neurogenesis and gliogenesis. The lateral ventricular zone produces different classes of excitatory pyramidal cells until just before birth, when the production of ast…