Robert C. Bauer
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View article: Depot-Specific Roles for C/EBPα in White Adipose Tissue Development and Metabolism
Depot-Specific Roles for C/EBPα in White Adipose Tissue Development and Metabolism Open
Rates of obesity and its associated metabolic comorbidities continue to rise in the developed world. It is well established that in obesity, the distribution and not just amount of excess white adipose tissue (WAT) correlates with a person…
View article: <i>LIPA</i> , a risk locus for coronary artery disease: decoding the variant-to-function relationship
<i>LIPA</i> , a risk locus for coronary artery disease: decoding the variant-to-function relationship Open
Background and Aims Translating human genomic discoveries into mechanistic insights requires linking genetic variations to candidate genes and their causal functional phenotypes. Genome-wide association studies have consistently identified…
View article: Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation
Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation Open
Background Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibroblast-like, macrophage-like, …
View article: Refining the methodology for verifying GLP studies submitted within an application for regulated products
Refining the methodology for verifying GLP studies submitted within an application for regulated products Open
OECD Good Laboratory Practice (GLP) principles were developed by governments as a regulatory control mechanism to ensure that safety studies would be of acceptable quality and integrity. EU Directives 2004/09/EC and 2004/10/EC incorporate …
View article: Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis
Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis Open
Background Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the western world despite the success of lipid lowering therapies, highlighting the need for novel lipid-independent therapeutic strategies…
View article: ADAMTS7 Promotes Smooth Muscle Cell Foam Cell Expansion in Atherosclerosis
ADAMTS7 Promotes Smooth Muscle Cell Foam Cell Expansion in Atherosclerosis Open
Human genetic studies have repeatedly associated SNPs near the gene ADAMTS7 with atherosclerotic cardiovascular disease. Subsequent investigations in mice demonstrated that ADAMTS7 is proatherogenic, induced in response to vascular injury,…
View article: Single-cell multimodal profiling of atherosclerosis identifies CD200 as a cell surface lineage marker of vascular smooth muscle cells and their derived cells
Single-cell multimodal profiling of atherosclerosis identifies CD200 as a cell surface lineage marker of vascular smooth muscle cells and their derived cells Open
Vascular smooth muscle cells (VSMCs) play a central role in the development of atherosclerosis due in part to their capability to phenotypically transition into either a protective or harmful state. However, the ability to identify and tra…
View article: High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis Open
Background Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, we have limited understanding of the comprehensive transcriptional and phenotypical landscape of the cells within these lesions. …
View article: Data from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment
Data from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment Open
Purpose: Dasatinib and nilotinib are active in imatinib-resistant chronic myelocytic leukemia (CML) and many patients undergo sequential treatment. We aimed at modeling sequential tyrosine kinase inhibitor (TKI) resistance in vitro to comp…
View article: Supplementary Table 1 from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment
Supplementary Table 1 from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment Open
PDF File - 120K, BCR-ABL kinase domain mutations recovered in the sequential screen with IC50-values for imatinib, dasatinib and nilotinib.
View article: Data from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment
Data from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment Open
Purpose: Dasatinib and nilotinib are active in imatinib-resistant chronic myelocytic leukemia (CML) and many patients undergo sequential treatment. We aimed at modeling sequential tyrosine kinase inhibitor (TKI) resistance in vitro to comp…
View article: Supplementary Table 1 from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment
Supplementary Table 1 from Sequential Inhibitor Therapy in CML: <i>In Vitro</i> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment Open
PDF File - 120K, BCR-ABL kinase domain mutations recovered in the sequential screen with IC50-values for imatinib, dasatinib and nilotinib.
View article: Decoding the variant-to-function relationship for<i>LIPA</i>, a risk locus for coronary artery disease
Decoding the variant-to-function relationship for<i>LIPA</i>, a risk locus for coronary artery disease Open
Translating human genomic discoveries into mechanistic insights requires linking genetic variations to candidate genes and their causal functional phenotypes. Genome-wide association studies have consistently identified LIPA as a risk locu…
View article: HMGA2 Immunoexpression is frequent in salivary gland pleomorphic adenoma: immunohistochemical and molecular analyses of <i>PLAG1</i> and HMGA2 in 25 cases.
HMGA2 Immunoexpression is frequent in salivary gland pleomorphic adenoma: immunohistochemical and molecular analyses of <i>PLAG1</i> and HMGA2 in 25 cases. Open
The main oncologic events in pleomorphic adenoma (PA) are the translocations of Pleomorphic adenoma gene 1 (PLAG1) on chromosome 8q12 and High-mobility group AT-hook 2 (HMGA2) on chromosome 12q14.3 with various fusion partners. These trans…
View article: Adipocyte-specific tribbles pseudokinase 1 regulates plasma adiponectin and plasma lipids in mice
Adipocyte-specific tribbles pseudokinase 1 regulates plasma adiponectin and plasma lipids in mice Open
This study shows that adipocyte Trib1 regulates multiple aspects of metabolic health, confirming previously observed genetic associations in humans and shedding light on the further mechanisms by which TRIB1 regulates plasma lipids and met…
View article: Building Your Mentoring Network in Your Early Career
Building Your Mentoring Network in Your Early Career Open
The pursuit of knowledge, curiosity about the natural world, and a drive to better the human condition are several of the many motivations that encourage someone to further their education in the biological sciences. However noble the inte…
View article: Distinct mechanoreceptor <i>pezo-1</i> isoforms modulate food intake in the nematode <i>Caenorhabditis elegans</i>
Distinct mechanoreceptor <i>pezo-1</i> isoforms modulate food intake in the nematode <i>Caenorhabditis elegans</i> Open
Two PIEZO mechanosensitive cation channels, PIEZO1 and PIEZO2, have been identified in mammals, where they are involved in numerous sensory processes. While structurally similar, PIEZO channels are expressed in distinct tissues and exhibit…
View article: Competing tissue-specific functions for the Tribbles-1 plasma lipid associated locus
Competing tissue-specific functions for the Tribbles-1 plasma lipid associated locus Open
Purpose of review The pseudokinase Tribbles-1 ( TRIB1 ) remains the focus of intense research since genome-wide association studies (GWAS) associated it with multiple cardiometabolic traits in humans, including plasma lipids and atheroscle…
View article: Adipocyte Tribbles1 Regulates Plasma Adiponectin and Plasma Lipids in Mice
Adipocyte Tribbles1 Regulates Plasma Adiponectin and Plasma Lipids in Mice Open
Multiple GWAS have identified SNPs in the 8q24 locus near the TRIB1 gene that significantly associate with plasma lipids and coronary artery disease. While subsequent studies have uncovered roles for hepatic and myeloid Trib1 in contributi…
View article: Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion
Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion Open
Trib1 controls atherosclerotic plaque macrophage function by up-regulating OLR1, promoting foam cell formation and atherosclerosis.
View article: Alagille syndrome mutation update: Comprehensive overview of<i>JAG1</i>and<i>NOTCH2</i>mutation frequencies and insight into missense variant classification
Alagille syndrome mutation update: Comprehensive overview of<i>JAG1</i>and<i>NOTCH2</i>mutation frequencies and insight into missense variant classification Open
Alagille syndrome is an autosomal dominant disease with a known molecular etiology of dysfunctional Notch signaling caused primarily by pathogenic variants in JAGGED1 (JAG1), but also by variants in NOTCH2. The majority of JAG1 variants re…
View article: Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver
Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver Open
Deciphering the impact of genetic variation on gene regulation is fundamental to understanding common, complex human diseases. Although histone modifications are important markers of gene regulatory elements of the genome, any specific his…
View article: Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion
Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion Open
Macrophages drive atherosclerotic plaque progression and rupture, hence attenuating their atherosclerosis-inducing properties holds promise for reducing coronary heart disease (CHD). Recent studies in mouse models have demonstrated that Tr…
View article: Trouble With Tribbles-1
Trouble With Tribbles-1 Open
Genome-wide association studies (GWAS) have identified hundreds of genomic loci in humans that are significantly associated with plasma cholesterol, triglycerides, and coronary artery disease. Although some loci contain genes with known re…
View article: Genetics-driven discovery of novel regulators of lipid metabolism
Genetics-driven discovery of novel regulators of lipid metabolism Open
Purpose of review Residual cardiovascular disease risk and increasing metabolic syndrome risk underscores a need for novel therapeutics targeting lipid metabolism in humans. Unbiased human genetic screens have proven powerful in identifyin…