Robert C. Gallo
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View article: A randomized, controlled trial to evaluate the efficacy of a daily report card intervention to enhance the efficacy of individualized education programs for children with attention-deficit/hyperactivity disorder.
A randomized, controlled trial to evaluate the efficacy of a daily report card intervention to enhance the efficacy of individualized education programs for children with attention-deficit/hyperactivity disorder. Open
Overall, the DRC appears to be a viable approach for positively supporting children with ADHD who are receiving special education supports in schools, particularly for improving behavior in the classroom. (PsycInfo Database Record (c) 2025…
View article: Early elevated IFNα is a key mediator of HIV pathogenesis
Early elevated IFNα is a key mediator of HIV pathogenesis Open
Background A complete understanding of the different steps of HIV replication and an effective drug combination have led to modern antiretroviral regimens that block HIV replication for decades, but these therapies are not curative and mus…
View article: IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation Open
Background Among people living with HIV, elite controllers (ECs) maintain an undetectable viral load, even without receiving anti-HIV therapy. In non-EC patients, this therapy leads to marked improvement, including in immune parameters, bu…
View article: Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU
Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU Open
View article: Mycoplasma DnaK expression increases cancer development in vivo upon DNA damage
Mycoplasma DnaK expression increases cancer development in vivo upon DNA damage Open
Well-controlled repair mechanisms are involved in the maintenance of genomic stability, and their failure can precipitate DNA abnormalities and elevate tumor risk. In addition, the tumor microenvironment, enriched with factors inducing oxi…
View article: Mycoplasma DnaK increases DNA copy number variants in vivo
Mycoplasma DnaK increases DNA copy number variants in vivo Open
The human microbiota affects critical cellular functions, although the responsible mechanism(s) is still poorly understood. In this regard, we previously showed that Mycoplasma fermentans DnaK, an HSP70 chaperone protein, hampers the activ…
View article: The role of trained immunity in COVID-19: Lessons for the next pandemic
The role of trained immunity in COVID-19: Lessons for the next pandemic Open
View article: Early Elevated IFNα Identified as the Key Mediator of HIV Pathogenesis and its low level a Hallmark of Elite Controllers
Early Elevated IFNα Identified as the Key Mediator of HIV Pathogenesis and its low level a Hallmark of Elite Controllers Open
View article: IFNα induces CCR5 in CD4+ T-cells, causing its anti- HIV inefficiency and its subsequent pathogenic elevation, partially controlled by anti-HIV therapy
IFNα induces CCR5 in CD4+ T-cells, causing its anti- HIV inefficiency and its subsequent pathogenic elevation, partially controlled by anti-HIV therapy Open
Like EC, we find that ART-treated patients control serum IFNα concentration and show few immune cell alterations enabling a healthy but fragile medical status. However, treatment interruption leads to elevated IFNα reflecting virus product…
View article: Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies
Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies Open
The widespread outbreak of the monkeypox virus (MPXV) recognized in 2022 poses new challenges for public healthcare systems worldwide. With more than 86,000 people infected, there is concern that MPXV may become endemic outside of its orig…
View article: Characterization of the interactome profiling of Mycoplasma fermentans DnaK in cancer cells reveals interference with key cellular pathways
Characterization of the interactome profiling of Mycoplasma fermentans DnaK in cancer cells reveals interference with key cellular pathways Open
Chaperone proteins are redundant in nature and, to achieve their function, they bind a large repertoire of client proteins. DnaK is a bacterial chaperone protein that recognizes misfolded and aggregated proteins and drives their folding an…
View article: HIV-1 mutants expressing B cell clonogenic matrix protein p17 variants are increasing their prevalence worldwide
HIV-1 mutants expressing B cell clonogenic matrix protein p17 variants are increasing their prevalence worldwide Open
AIDS-defining cancers declined after combined antiretroviral therapy (cART) introduction, but lymphomas are still elevated in HIV type 1 (HIV-1)–infected patients. In particular, non-Hodgkin’s lymphomas (NHLs) represent the majority of all…
View article: Reflections on Some of the Exceptional Features of HTLV-1 and HTLV-1 Research: A Perspective
Reflections on Some of the Exceptional Features of HTLV-1 and HTLV-1 Research: A Perspective Open
The report is not a review or a summary. In a manner, it is a perspective but an unusual one. It looks back to the years my colleagues and I (RG) began preparing for human retroviruses (beginning in 1970), how they evolved, and attempts to…
View article: Use of oral polio vaccine and the incidence of COVID-19 in the world
Use of oral polio vaccine and the incidence of COVID-19 in the world Open
Background Several live attenuated vaccines were shown to provide temporary protection against a variety of infectious diseases through stimulation of the host innate immune system. Objective To test the hypothesis that countries using ora…
View article: COVID-19 Infection Among Women in Iran Exposed vs Unexposed to Children Who Received Attenuated Poliovirus Used in Oral Polio Vaccine
COVID-19 Infection Among Women in Iran Exposed vs Unexposed to Children Who Received Attenuated Poliovirus Used in Oral Polio Vaccine Open
In this cohort study, indirect exposure to live attenuated poliovirus was associated with decreased symptomatic infection with COVID-19. Further study of the potential protective effect of OPV should be conducted, especially in nations whe…
View article: Publisher Correction: Rolf Neth (October 6, 1926–March 17, 2020)
Publisher Correction: Rolf Neth (October 6, 1926–March 17, 2020) Open
View article: Safety and immunogenicity of an HIV-1 gp120-CD4 chimeric subunit vaccine in a phase 1a randomized controlled trial
Safety and immunogenicity of an HIV-1 gp120-CD4 chimeric subunit vaccine in a phase 1a randomized controlled trial Open
A major challenge for HIV vaccine development is to raise anti-envelope antibodies capable of recognizing and neutralizing diverse strains of HIV-1. Accordingly, a full length single chain (FLSC) of gp120-CD4 chimeric vaccine construct was…
View article: Viruses and Bacteria Associated with Cancer: An Overview
Viruses and Bacteria Associated with Cancer: An Overview Open
There are several human viruses and bacteria currently known to be associated with cancer. A common theme indicates that these microorganisms have evolved mechanisms to hamper the pathways dedicated to maintaining the integrity of genetic …
View article: Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics
Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics Open
The COVID-19 pandemic triggered an unparalleled pursuit of vaccines to induce specific adaptive immunity, based on virus-neutralizing antibodies and T cell responses. Although several vaccines have been developed just a year after SARS-CoV…
View article: Analysis of DnaK Expression from a Strain of Mycoplasma fermentans in Infected HCT116 Human Colon Carcinoma Cells
Analysis of DnaK Expression from a Strain of Mycoplasma fermentans in Infected HCT116 Human Colon Carcinoma Cells Open
Several species of mycoplasmas, including Mycoplasma fermentans, are associated with certain human cancers. We previously isolated and characterized in our laboratory a strain of human mycoplasma M. fermentans subtype incognitus (MF-I1) ab…
View article: Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines
Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines Open
Background Studies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical cellular pathways b…
View article: Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation
Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation Open
A reduced ability to properly repair DNA is linked to a variety of human diseases, which in almost all cases is associated with an increased probability of the development of cellular transformation and cancer. DNA damage, that ultimately …
View article: The Great Coronavirus Pandemic of 2019−2021: the Future and the Requirement for China-America Cooperation
The Great Coronavirus Pandemic of 2019−2021: the Future and the Requirement for China-America Cooperation Open
Over the past century, the great pandemics and most epidemics (defined as virus presence and disease induction presenting more than the expected number of infections in a population) were caused by the sudden outbreak of an RNA virus such …
View article: Evolution toward beta common chain receptor usage links the matrix proteins of HIV-1 and its ancestors to human erythropoietin
Evolution toward beta common chain receptor usage links the matrix proteins of HIV-1 and its ancestors to human erythropoietin Open
Significance Immune activation and inflammation are predictors of serious non-AIDS events even in virally suppressed HIV-1−infected individuals. This does not apply to HIV-2−infected patients, who experience a form of attenuated HIV-1 dise…
View article: Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1
Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1 Open
Background The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic. Phylogenetic analysis revealed that it is simila…
View article: Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1
Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1 Open
Background :The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic.Phylogenetic analysis revealed that it is similar…
View article: Covid‐19: Time for a paradigm change
Covid‐19: Time for a paradigm change Open
The authors have no competing interest.
View article: Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas
Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas Open
View article: Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas.
Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas. Open
Background With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and population density, with d…
View article: Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas.
Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas. Open
Background With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and population density, with d…