Robert J. Harris
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View article: Resolving the Young 2 Cygni Run-away Star into a Binary using iLocater
Resolving the Young 2 Cygni Run-away Star into a Binary using iLocater Open
Precision radial velocity (RV) spectrographs that use adaptive optics (AO) show promise to advance telescope observing capabilities beyond those of seeing-limited designs. We are building a spectrograph for the Large Binocular Telescope (L…
View article: The Blue Multi Unit Spectroscopic Explorer (BlueMUSE) on the VLT: science drivers and overview of instrument design
The Blue Multi Unit Spectroscopic Explorer (BlueMUSE) on the VLT: science drivers and overview of instrument design Open
BlueMUSE is a blue-optimised, medium spectral resolution, panoramic integral\nfield spectrograph under development for the Very Large Telescope (VLT). With\nan optimised transmission down to 350 nm, spectral resolution of R$\\sim$3500 on\n…
View article: THE ACOUSTIC DESIGN OF THE BRIDGEWATER HALL, MANCHESTER
THE ACOUSTIC DESIGN OF THE BRIDGEWATER HALL, MANCHESTER Open
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View article: Supplementary Figure 3 from Cell Motility in Chronic Lymphocytic Leukemia: Defective Rap1 and αLβ2 Activation by Chemokine
Supplementary Figure 3 from Cell Motility in Chronic Lymphocytic Leukemia: Defective Rap1 and αLβ2 Activation by Chemokine Open
Supplementary Figure 3 from Cell Motility in Chronic Lymphocytic Leukemia: Defective Rap1 and αLβ2 Activation by Chemokine
View article: Supplementary Table 1 from c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic Implications
Supplementary Table 1 from c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic Implications Open
Supplementary Table 1 from c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic Implications
View article: Supplementary Plot 1 from c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic Implications
Supplementary Plot 1 from c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic Implications Open
Supplementary Plot 1 from c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic Implications
View article: Natural Language Processing and Machine Learning for Detection of Respiratory Illness by Chest CT Imaging and Tracking of COVID-19 Pandemic in the United States
Natural Language Processing and Machine Learning for Detection of Respiratory Illness by Chest CT Imaging and Tracking of COVID-19 Pandemic in the United States Open
Using big data, we developed a novel machine-learning based NLP algorithm that can track imaging findings of respiratory illness detected on chest CT imaging reports with strong correlation with the progression of the COVID-19 pandemic in …
View article: NIMG-59. VALIDATION OF QUANTITATIVE VESSEL SIZE IMAGING (VSI) IN HUMAN GLIOMAS USING IMAGE-GUIDED STEREOTACTIC BIOPSIES
NIMG-59. VALIDATION OF QUANTITATIVE VESSEL SIZE IMAGING (VSI) IN HUMAN GLIOMAS USING IMAGE-GUIDED STEREOTACTIC BIOPSIES Open
Angiogenesis is critical for brain tumor development and malignant transformation1, influencing both prognosis and response to therapy. The vessel size imaging (VSI) 2 is a quantitative technique that estimates the mean diameter of vessels…
View article: High-throughput image labeling and quality control for clinical trials using machine learning
High-throughput image labeling and quality control for clinical trials using machine learning Open
Background: Manually importing and analyzing image data can be time-consuming, prone to human error, and costly for large clinical trial datasets. This can lead to delays in quality control (QC) feedback to imaging sites and in obtaining d…
View article: Bevacizumab at first recurrence after standard radio-chemotherapy is associated with improved overall survival in glioblastoma patients with large tumor burden
Bevacizumab at first recurrence after standard radio-chemotherapy is associated with improved overall survival in glioblastoma patients with large tumor burden Open
Background Since its approval for use in recurrent glioblastoma (GBM), the survival benefit of bevacizumab (Bev) remains to be demonstrated. To address this issue, we retrospectively examined survival from first recurrence in patients trea…
View article: Post-chemoradiation volumetric response predicts survival in newly diagnosed glioblastoma treated with radiation, temozolomide, and bevacizumab or placebo
Post-chemoradiation volumetric response predicts survival in newly diagnosed glioblastoma treated with radiation, temozolomide, and bevacizumab or placebo Open
Background In the current study we used contrast-enhanced T1 subtraction maps to test whether early changes in enhancing tumor volume are prognostic for overall survival (OS) in newly diagnosed glioblastoma (GBM) patients treated with chem…
View article: Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma
Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma Open
T1 subtraction maps provide value in determining response in recurrent GBM treated with cabozantinib and correlated with survival benefit.
View article: Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials
Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials Open
Purpose: Anti-VEGF therapies remain controversial in the treatment of recurrent glioblastoma (GBM). In the current study, we demonstrate that recurrent GBM patients with a specific diffusion MR imaging signature have an overall survival (O…
View article: NIMG-31. RESIDUAL ENHANCING TUMOR VOLUME IS A STRONG PROGNOSTIC BIOMARKER FOR SURVIVAL IN BOTH NEWLY DIAGNOSED AND RECURRENT GBM REGARDLESS OF THERAPY: EVIDENCE FROM 1,535 PATIENTS IN SINGLE AND MULTICENTER TRIALS
NIMG-31. RESIDUAL ENHANCING TUMOR VOLUME IS A STRONG PROGNOSTIC BIOMARKER FOR SURVIVAL IN BOTH NEWLY DIAGNOSED AND RECURRENT GBM REGARDLESS OF THERAPY: EVIDENCE FROM 1,535 PATIENTS IN SINGLE AND MULTICENTER TRIALS Open
The prognostic significance of residual or baseline contrast enhancing tumor volume prior to initiation of chemotherapy in both newly diagnosed and recurrent GBM for OS remains controversial, particularly in the context of surgical resecti…
View article: Baseline pretreatment contrast enhancing tumor volume including central necrosis is a prognostic factor in recurrent glioblastoma: evidence from single and multicenter trials
Baseline pretreatment contrast enhancing tumor volume including central necrosis is a prognostic factor in recurrent glioblastoma: evidence from single and multicenter trials Open
Baseline tumor volume is a significant prognostic factor in recurrent GBM. Clinical trial treatment arms must have a balanced distribution of tumor size, and tumor size should be considered when interpreting therapeutic efficacy.
View article: DTI of tuber and perituberal tissue can predict epileptogenicity in tuberous sclerosis complex
DTI of tuber and perituberal tissue can predict epileptogenicity in tuberous sclerosis complex Open
DTI analysis of tubers and perituberal tissue may help to identify epileptogenic tubers in presurgical patients with TSC more easily and effectively than current invasive methods.
View article: Diffusion MRI Characteristics after Concurrent Radiochemotherapy Predicts Progression-Free and Overall Survival in Newly Diagnosed Glioblastoma
Diffusion MRI Characteristics after Concurrent Radiochemotherapy Predicts Progression-Free and Overall Survival in Newly Diagnosed Glioblastoma Open
The standard of care for newly diagnosed glioblastoma (GBM) is surgery first, radiotherapy (RT) with concurrent temozolomide (TMZ) second, and adjuvant TMZ last. We hypothesized patients with low diffusivity measured using apparent diffusi…
View article: pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI
pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI Open
Results suggest pH-weighted MRI may provide new insight into brain tumor physiology beyond traditional imaging technologies.
View article: c-Myc inhibition decreases CIP2A and reduces BCR-ABL1 tyrosine kinase activity in chronic myeloid leukemia
c-Myc inhibition decreases CIP2A and reduces BCR-ABL1 tyrosine kinase activity in chronic myeloid leukemia Open
Chronic myeloid leukemia (CML) is a malignant disease of the primitive hematologic cell which is driven by BCR-ABL1 tyrosine kinase activity.[1][1] Although in recent years CML treatment has been drastically improved by the tyrosine kinase…